The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evaluation of Ultra-Thin Poly(ε-Caprolactone) Films for Tissue-Engineered Skin
Abstract
Various natural and synthetic polymeric materials have been used as scaffold matrices for tissue-engineered skin. However, the commercially available skin replacement products pose problems of poor mechanical properties and immunological rejection. We have thus developed a film of 5 microm thickness, via biaxial stretching of poly(epsilon-caprolactone) (PCL), as a potential matrix for living skin replacements. The aim of this study was to evaluate the feasibility of using biaxially stretched PCL films as matrices for culturing human dermal fibroblasts. For this purpose, we cultured human dermal fibroblasts for 7 days on the films. Glass cover slips and polyurethane (PU) sheets were used as controls. The data from phase contrast light, confocal laser, and scanning electron microscopy suggested that biaxially stretched PCL films support the attachment and proliferation of human dermal fibroblasts. Thymidine-labeling results showed quantitatively that cell proliferation on the PCL films was superior to that on the PU samples. These results indicated that biaxially stretched PCL films supported the growth of human dermal fibroblasts and might have potential to be applied in tissue engineering a dermal equivalent or skin graft.
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Cites
Parameters affecting cellular adhesion to polylactide films
Burg, K. J. L., Holder, W. D., Culberson, C. R., Beiler, R. J., Greene, K. G., Loebsack, A. B., Roland, W. D., Mooney, D. J., & Halberstadt, C. R. (1999) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856299x00108 · Cited by 69
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Zhong, S. P., Zhang, Y. Z., & Lim, C. T. (2010) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.100 · Cited by 687
Li, W., Danielson, K. G., Alexander, P. G., & Tuan, R. S. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10101 · Cited by 536
Zhu, Y., Gao, C., Liu, X., & Shen, J. (2002) · Biomacromolecules · doi:10.1021/bm020074y · Cited by 476
An improved hydrophilicity via electrospinning for enhanced cell attachment and proliferation
Kim, C. H., Khil, M. S., Kim, H. Y., Lee, H. U., & Jahng, K. Y. (2006) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.30484 · Cited by 326
Zhang, J., Zhao, S., Zhu, M., Zhu, Y., Zhang, Y., Liu, Z., & Zhang, C. (2014) · J. Mater. Chem. B · doi:10.1039/c4tb01063a · Cited by 317
Metadata
- Authors
- Ng, K. W., Hutmacher, D. W., Schantz, J.-T., Ng, C. S., Too, H.-P., Lim, T. C., Phan, T. T., & Teoh, S. H.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2001-08
- Volume
- 7
- Issue
- 4
- Pages
- 441-455
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W2178633787
- Cited by
- 179
- References
- 1
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ng, K. W., Hutmacher, D. W., Schantz, J.-T., Ng, C. S., Too, H.-P., Lim, T. C., Phan, T. T., & Teoh, S. H. (2001). Evaluation of Ultra-Thin Poly(ε-Caprolactone) Films for Tissue-Engineered Skin. Tissue Engineering. https://doi.org/10.1089/10763270152436490
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