The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Review: Role of Blood Platelets in Infection and Inflammation
Abstract
Blood platelets are here presented as active players in antimicrobial host defense and the induction of inflammation and tissue repair in addition to their participation in hemostasis. Megakaryopoiesis is inhibited after acute infection with viruses or bacteria. In contrast, chronic inflammation is often associated with reactive thrombocytosis. Platelets can bind and internalize pathogens and release microbicidal proteins that kill certain bacteria and fungi. By making cell-cell contacts with leukocytes and endothelial cells, platelets assist white blood cells in rolling, arrest and transmigration. On stimulation by bacteria or thrombin, platelets release the content of their alpha-granules, which include an arsenal of bioactive peptides, such as CC-chemokines and CXC-chemokines and growth factors for endothelial cells, smooth muscle cells and fibroblasts. Thus, integral to innate immunity, the tiny little platelets may become bombshells when irritated by pathogens.
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Cites
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
Kaser, A., Brandacher, G., Steurer, W., Kaser, S., Offner, F. A., Zoller, H., Theurl, I., Widder, W., Molnar, C., Ludwiczek, O., et al. (2001) · Blood · doi:10.1182/blood.v98.9.2720 · Cited by 667 · cited 1×
“(29,42) In contrast, the capacity of IL-6 to stimulate TPO production in human hepatoma cell cultures has been confirmed by several investigators, (38,43) and administration of IL-6 to cancer patients produces an increase in their plasma TPO concentrations (43) and blood platelet counts.”
Cited by
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309
Platelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
Templeton, A. J., Ace, O., McNamara, M. G., Al-Mubarak, M., Vera-Badillo, F. E., Hermanns, T., Šeruga, B., Ocaña, A., Tannock, I. F., & Amir, E. (2014) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0146 · Cited by 719
Smith, R. A., Bosonnet, L., Raraty, M., Sutton, R., Neoptolemos, J. P., Campbell, F., & Ghaneh, P. (2009) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2007.12.057 · Cited by 458
Krenn-Pilko, S., Langsenlehner, U., Thurner, E.-M., Stojakovic, T., Pichler, M., Gerger, A., Kapp, K. S., & Langsenlehner, T. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.163 · Cited by 281
Metadata
- Authors
- Klinger, M. H. F., & Jelkmann, W.
- Venue
- Journal of Interferon & Cytokine Research
- Publisher
- SAGE Publications
- Published
- 2002-09
- Volume
- 22
- Issue
- 9
- Pages
- 913-922
- ISSN
- 1079-9907 (ISSN-L)
- 1557-7465
- OpenAlex
- W2016722329
- Cited by
- 505
- References
- 2
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
