Receptor Specificity of the Fibroblast Growth Factor Family
Open accessAbstract
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual FGF receptors. To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants. Using FGF 1 as an internal standard we have determined the relative activity of all the other members of the FGF family. These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways.
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FGF5 plays essential roles in the regulation of cell proliferation, including in cardiac myocytes, and cell differentiation.
“For example, FGF5 plays essential roles in the regulation of cell proliferation, including in cardiac myocytes, and cell differentiation73”
From Genetic determinants of plasma protein levels in the Estonian population (2024) · cites this paper as [73]
The paper reports testing FGF5’s mitogenic activity in FGFR-expressing BaF3 cells and states in the Discussion that FGF5 activates certain receptor splice forms. That supports a limited connection to cell proliferation, but our copy does not establish an essential role for FGF5 in cardiac-myocyte proliferation or cell differentiation. (LLM, conf=0.86)
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- Authors
- Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M.
- Affiliations
- Washington University in St. Louis (US)
- Inserm (FR)
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Ornitz, David M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 271
- Issue
- 25
- Pages
- 15292-15297
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2072303535
- Cited by
- 1,871
- References
- 1
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 41 · 2023: 39 · 2022: 27 · 2021: 40 · 2020: 45 · 2019: 42 · 2018: 25 · 2017: 42 · 2016: 51 · 2015: 69 · 2014: 65 · 2013: 95 · 2012: 101
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA-60673, R01CA060673)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- fibroblast growth factor, fibroblast growth factor receptor, FGF1, receptor splice variants, mitogenic activity, heparan sulfate proteoglycans, FGF signaling, developmental signaling
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Fibroblast Growth Factors, Humans, Kinetics, Ligands, Molecular Sequence Data, Protein-Tyrosine Kinases, Substrate Specificity, Genetic Variation, Alternative Splicing, Receptors, Fibroblast Growth Factor, Receptor Protein-Tyrosine Kinases, Mice, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Receptor, Fibroblast Growth Factor, Type 3, Receptor, Fibroblast Growth Factor, Type 4
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