Cited by 269Heavy Metal Exposure and ToxicityTrace Elements in HealthMetal complexes synthesis and properties

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Zinc Finger Proteins as Potential Targets for Toxic Metal Ions: Differential Effects on Structure and Function

Hartwig, Andrea·2001·Antioxidants & Redox Signaling

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Abstract

Zinc finger structures are frequently found in transcription factors and DNA repair proteins, mediating DNA-protein and protein-protein binding. As low concentrations of transition metal compounds, including those of cadmium, nickel, and cobalt, have been shown to interfere with DNA transcription and repair, several studies have been conducted to elucidate potential interactions of toxic metal ions with zinc-binding protein domains. Various effects have been identified, including the displacement of zinc, e.g., by cadmium or cobalt, the formation of mixed complexes, incomplete coordination of toxic metal ions, as well as the oxidation of cysteine residues within the metal-binding domain. Besides the number of cysteine and/or histidine ligands, unique structural features of the respective protein under investigation determine whether or not zinc finger structures are disrupted by one or more transition metals. As improper folding of zinc finger domains is mostly associated with the loss of correct protein function, disruption of zinc finger structures may result in interference with manifold cellular processes involved in gene expression, growth regulation, and maintenance of the genomic integrity.

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Authors: Hartwig, A.
Affiliations: Karlsruhe Institute of Technology (DE)
Corresponding author: Hartwig, Andrea
ORCID: Hartwig, Andrea
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2001-08
Volume: 3
Issue: 4
Pages: 625-634
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/15230860152542970
OpenAlex: W1983045184
Cited by: 269
References: 63
Citations by year: 2026: 8 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 15 · 2013: 12 · 2012: 14
FWCI: 7.38
Type: journal article
Language: en
Open access: closed
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Keywords: zinc finger proteins, toxic metal ions, cadmium, nickel, cobalt, metal ion binding, zinc displacement, heterometallic complexes, cysteine oxidation, histidine ligands, protein misfolding, transcription factors, DNA repair proteins
MeSH terms: Binding, Competitive, DNA, DNA Repair, Humans, Metals, Neoplasm Proteins, Protein Binding, Protein Conformation, Structure-Activity Relationship, Transcription Factors, Transcription, Genetic, Xeroderma Pigmentosum, Zinc Fingers, Protein Folding, Denys-Drash Syndrome

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Zinc Finger Proteins as Potential Targets for Toxic Metal Ions: Differential Effects on Structure and Function

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