Gene Therapy with Viral Vectors: The Hope, the Problems, and the Solution
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
To date, 5 main classes of viral vectors have been tested for clinical applications: retroviruses, adenoviruses, adeno-associated viruses, lentiviruses, and herpes simplex viruses.
“To date, 5 main classes of viral vectors have been tested for clinical applications.25,27 These include retroviruses (RV), adenoviruses (AV), adenoassociated viruses (AAV), lentiviruses (LV), and herpes simplex viruses (HSV).”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [27]
Cites
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.
Cavazzana-Calvo, M., Hacein-Bey, S., Basile, G. D. S., Gross, F., Yvon, E., Nusbaum, P., Selz, F., Hue, C., Certain, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,703 · see citing works
Kay, M. A., Manno, C. S., Ragni, M. V., Larson, P. J., Couto, L. B., McClelland, A., Glader, B. E., Chew, A. K., Tai, S. J., Herzog, R. W., et al. (2000) · Nature Genetics · doi:10.1038/73464 · Cited by 1,019 · see citing works
Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus
Wagner, J. A., Reynolds, T. C., Moran, M. L., Moss, R. B., Wine, J. J., Flotte, T. R., & Gardner, P. I. (1998) · The Lancet · doi:10.1016/s0140-6736(05)77740-0 · Cited by 225 · see citing works
James D. Griffin, M.D., Harvard Medical School
Glaser, V. P. (2001) · Stem Cells and Development · doi:10.1089/15258160151134863 · Cited by 1 · see citing works
Bodine, D. M. (2001) · Stem Cells and Development · doi:10.1089/152581601750098110 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ghosh, S., Brown, A. M., Jenkins, C., & Campbell, K. (2020) · Applied Biosafety · doi:10.1177/1535676019899502 · Cited by 218 · see citing works
- Authors
- Srivastava, A.
- Affiliations
- Indiana University School of Medicine (US)
- Corresponding author
- Srivastava, Arun
- ORCID
- Srivastava, Arun
- Venue
- Journal of Hematotherapy & Stem Cell Research
- Publisher
- SAGE Publications
- Published
- 2001-04
- Volume
- 10
- Issue
- 2
- Pages
- 321-322
- ISSN
- 1525-8165 (ISSN-L)
- OpenAlex
- W2089812946
- Cited by
- 4
- References
- 5
- Citations by year
- 2025: 1 · 2020: 1 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stem Cells and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- gene therapy, viral vectors, gene delivery, viral vector design, therapeutic vectors
- MeSH terms
- Dependovirus, Genetic Vectors, Hematopoietic Stem Cells, Humans, Retroviridae, Genetic Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
