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Experimental Protein Mixture for Validating Tandem Mass Spectral Analysis
Abstract
Several methods have been used to identify peptides that correspond to tandem mass spectra. In this work, we describe a data set of low energy tandem mass spectra generated from a control mixture of known protein components that can be used to evaluate the accuracy of these methods. As an example, these spectra were searched by the SEQUEST application against a human peptide sequence database. The numbers of resulting correct and incorrect peptide assignments were then determined. We show how the sensitivity and error rate are affected by the use of various filtering criteria based upon SEQUEST scores and the number of tryptic termini of assigned peptides.
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Cited by
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PepNovo: De Novo Peptide Sequencing via Probabilistic Network Modeling
Frank, A., & Pevzner, P. (2005) · Analytical Chemistry · doi:10.1021/ac048788h · Cited by 688
InsPecT: Identification of Posttranslationally Modified Peptides from Tandem Mass Spectra
Tanner, S., Shu, H., Frank, A., Wang, L.-C., Zandi, E., Mumby, M., Pevzner, P. A., & Bafna, V. (2005) · Analytical Chemistry · doi:10.1021/ac050102d · Cited by 567
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Zarnowski, R., Sanchez, H., Covelli, A. S., Dominguez, E., Jaromin, A., Bernhardt, J., Mitchell, K. F., Heiss, C., Azadi, P., Mitchell, A., et al. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006872 · Cited by 260
Coordination of fungal biofilm development by extracellular vesicle cargo
Zarnowski, R., Noll, A., Chevrette, M. G., Sanchez, H., Jones, R., Anhalt, H., Fossen, J., Jaromin, A., Currie, C., Nett, J. E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26525-z · Cited by 123
Metadata
- Authors
- Keller, A., Purvine, S., Nesvizhskii, A. I., Stolyar, S., Goodlett, D. R., & Kolker, E.
- Venue
- OMICS: A Journal of Integrative Biology
- Publisher
- SAGE Publications
- Published
- 2002-04
- Volume
- 6
- Issue
- 2
- Pages
- 207-212
- ISSN
- 1536-2310 (ISSN-L)
- 1557-8100
- OpenAlex
- W1543113652
- Cited by
- 261
- References
- 0
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Keller, A., Purvine, S., Nesvizhskii, A. I., Stolyar, S., Goodlett, D. R., & Kolker, E. (2002). Experimental Protein Mixture for Validating Tandem Mass Spectral Analysis. OMICS: A Journal of Integrative Biology. https://doi.org/10.1089/153623102760092805
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