Dehydroepiandrosterone (DHEA) and synthetic DHEA analogs are modest inhibitors of HIV-1 IIIB replication.
Abstract
Down-regulation of Epstein-Barr virus (EBV) induced transformation of human lymphocytes in vitro by dehydroepiandrosterone (DHEA), a naturally occurring human steroid secreted by the adrenal gland has been demonstrated. This article reports on the effects of DHEA and its novel synthetic analogs 16 alpha-fluoro-5-androsten-17-one (8354) and 3 beta-hydroxy-16 alpha-fluoro-5 alpha-androstan-17-one (OH8356) on human immunodeficiency virus (HIV-1) replication. Treatment with DHEA, 8354, or OH8356 resulted in a modest down-regulation of HIV-1 replication in phytohemagglutinin-stimulated peripheral blood lymphocytes as measured by syncytia formation, release of p24 antigen, and accumulation of reverse transcriptase activity. DHEA and 8354 also reduced syncytia formation in HIV-1-infected SupT1 lymphoblasts. DHEA and synthetic analogs of DHEA, which have been shown previously to have antiproliferative effects, now are shown to reduce HIV-1 replication. DHEA or synthetic analogs of DHEA could provide an alternative and/or adjuvant for HIV-1 infection.
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DHEA has immunomodulatory effects in vitro and in vivo in fungal and viral diseases, including HIV, and a stimulatory effect on the immune system in postmenopausal women.
“DHEA has been shown to have immunomodulatory effects in vitro (313) and in vivo in fungal and viral diseases (314), including HIV (315), and a stimulatory effect of DHEA on the immune system has been described in postmenopausal women (316).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [315]
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- Authors
- Henderson, E., Yang, J.-Y., & Schwartz, A.
- Affiliations
- Temple University (US)
- Venue
- AIDS Research and Human Retroviruses
- Publisher
- SAGE Publications
- Published
- 1992-05
- Volume
- 8
- Issue
- 5
- Pages
- 625-631
- ISSN
- 0889-2229 (ISSN-L)
- 1931-8405
- OpenAlex
- W2002333216
- Cited by
- 40
- References
- 22
- Citations by year
- 2024: 1 · 2021: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS Research and Human Retroviruses (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01ai028761-01)
- National Institute for Materials Science
- National Institute of Allergy and Infectious Diseases (5 R01 AI28761)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- dehydroepiandrosterone, HIV-1 replication inhibition, syncytium formation, reverse transcriptase activity, peripheral blood lymphocytes, Epstein-Barr virus transformation, adjuvant therapy
- MeSH terms
- Androstenes, Cell Division, Cell Line, Dehydroepiandrosterone, Humans, Kinetics, Lymphocyte Activation, RNA-Directed DNA Polymerase, T-Lymphocytes, Virus Replication, HIV-1, Giant Cells, HIV Core Protein p24
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