The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Peroxiredoxins, Oxidative Stress, and Cell Proliferation
Abstract
Peroxiredoxins (Prxs) are a family of multifunctional antioxidant thioredoxin-dependent peroxidases that have been identified in a large variety of organisms. The major functions of Prxs comprise cellular protection against oxidative stress, modulation of intracellular signaling cascades that apply hydrogen peroxide as a second messenger molecule, and regulation of cell proliferation. In the present review, we discuss pertinent findings on the protein structure, the cell- and tissue-specific distribution, as well as the subcellular localization of Prxs. A particular emphasis is put on Prx I, which is the most abundant and ubiquitously distributed member of the mammalian Prxs. Major transcriptional and posttranslational regulatory mechanisms and signaling pathways that control Prx gene expression and activity are summarized. The interaction of Prx I with the oncogene products c-Abl and c-Myc and the regulatory role of Prx I for cell proliferation and apoptosis are highlighted. Recent findings on phenotypical alterations of mouse models with targeted disruptions of Prx genes are discussed, confirming the physiological functions of Prxs for antioxidant cell and tissue protection along with an important role as tumor suppressors.
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Cites
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Cited by
Mechanisms of Cell Protection by Heme Oxygenase-1
Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105600 · Cited by 1,241
Activation of superoxide dismutases: Putting the metal to the pedal
Culotta, V. C., Yang, M., & O'Halloran, T. V. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.003 · Cited by 511
Oxidative stress in autoimmune rheumatic diseases
Smallwood, M. J., Nissim, A., Knight, A. R., Whiteman, M., Haigh, R., & Winyard, P. G. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.086 · Cited by 336
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation
Parmigiani, R. B., Xu, W. S., Venta-Perez, G., Erdjument-Bromage, H., Yaneva, M., Tempst, P., & Marks, P. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803749105 · Cited by 321
Metadata
- Authors
- Immenschuh, S., & Baumgart-Vogt, E.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2005-05
- Volume
- 7
- Issue
- 5-6
- Pages
- 768-777
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1986153062
- Cited by
- 302
- References
- 78
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
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