The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Oxidative Damage in Huntington's Disease Pathogenesis
Abstract
Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the progressive development of involuntary choreiform movements, cognitive impairment, neuropsychiatric symptoms, and premature death. These phenotypes reflect neuronal dysfunction and ultimately death in selected brain regions, the striatum and cerebral cortex being principal targets. The genetic mutation responsible for the HD phenotype is known, and its protein product, mutant huntingtin (mhtt), identified. HD is one of several "triplet repeat" diseases, in which abnormal expansions in trinucleotide repeat domains lead to elongated polyglutamine stretches in the affected gene's protein product. Mutant htt-mediated toxicity in the brain disrupts a number of vital cellular processes in the course of disease progression, including energy metabolism, gene transcription, clathrin-dependent endocytosis, intraneuronal trafficking, and postsynaptic signaling, but the crucial initiation mechanism induced by mhtt is still unclear. A large body of evidence, however, supports an early and critical involvement of defects in mitochondrial function and CNS energy metabolism in the disease trigger. Thus, downstream death-effector mechanisms, including excitotoxicity, apoptosis, and oxidative damage, have been implicated in the mechanism of selective neuronal damage in HD. Here we review the current evidence supporting a role for oxidative damage in the etiology of neuronal damage and degeneration in HD.
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Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
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Role of ROS and Nutritional Antioxidants in Human Diseases
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Buendia, I., Michalska, P., Navarro, E., Gameiro, I., Egea, J., & León, R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 678
The circadian clock and pathology of the ageing brain
Kondratova, A. A., & Kondratov, R. V. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3208 · Cited by 482
Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity
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Metadata
- Authors
- Browne, S. E., & Beal, M. F.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2006-11
- Volume
- 8
- Issue
- 11-12
- Pages
- 2061-2073
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1978138384
- Cited by
- 310
- References
- 144
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- closed
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