The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Oxidative Stress, Lens Gap Junctions, and Cataracts
Open accessAbstract
The eye lens is constantly subjected to oxidative stress from radiation and other sources. The lens has several mechanisms to protect its components from oxidative stress and to maintain its redox state, including enzymatic pathways and high concentrations of ascorbate and reduced glutathione. With aging, accumulation of oxidized lens components and decreased efficiency of repair mechanisms can contribute to the development of lens opacities or cataracts. Maintenance of transparency and homeostasis of the avascular lens depend on an extensive network of gap junctions. Communication through gap junction channels allows intercellular passage of molecules (up to 1 kDa) including antioxidants. Lens gap junctions and their constituent proteins, connexins (Cx43, Cx46, and Cx50), are also subject to the effects of oxidative stress. These observations suggest that oxidative stress-induced damage to connexins (and consequent altered intercellular communication) may contribute to cataract formation.
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Cites
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Oxidative stress and human health
Rahman, T., Hosen, I., Islam, M. M. T., & Shekhar, H. U. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.327123 · Cited by 489
Lens aging: Effects of crystallins
Sharma, K. K., & Santhoshkumar, P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.05.008 · Cited by 332
Cellular pathways for transport and efflux of ascorbate and dehydroascorbate
Corti, A., Casini, A. F., & Pompella, A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.014 · Cited by 193
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Metadata
- Authors
- Berthoud, V. M., & Beyer, E. C.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2009-02
- Volume
- 11
- Issue
- 2
- Pages
- 339-353
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1974409885
- Cited by
- 258
- References
- 101
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Berthoud, V. M., & Beyer, E. C. (2009). Oxidative Stress, Lens Gap Junctions, and Cataracts. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2008.2119
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
