The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria
Abstract
Hydrogen sulfide (H(2)S) is a synaptic modulator as well as a neuroprotectant in the brain. We recently showed that H(2)S protects neurons from oxidative stress by increasing the levels of glutathione (GSH), a major cellular antioxidant, by more than twice that of a control through enhancing the cystine transport. Here we show that H(2)S enhances the transport of cysteine to increase GSH production more than cystine transport and to redistribute the localization of GSH to mitochondria. The efficiency of GSH production enhanced by H(2)S is even greater by fourfold under oxidative stress by glutamate. H(2)S reinstated GSH levels in the fetal brain decreased by ischemia/reperfusion in utero. In addition, Neuro2a cells expressing a mitochondrial H(2)S-producing enzyme, 3-mercaptopyruvate sulfurtransferase (3MST), along with cysteine aminotransferase (CAT), showed significant resistance to oxidative stress. The present study shows that H(2)S protects cells from oxidative stress by two mechanisms. It enhances the production of GSH by enhancing cystine/cysteine transporters and redistributes GSH to mitochondria. H(2)S produced in mitochondria also may directly suppress oxidative stress. It provides a new mechanism of neuroprotection from oxidative stress by H(2)S.
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Cites
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The possible role of hydrogen sulfide as an endogenous neuromodulator
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Self-citationDithiothreitol, a New Protective Reagent for SH Groups*
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Cited by
Hydrogen Sulfide and Cell Signaling
Li, L., Rose, P., & Moore, P. K. (2011) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100505 · Cited by 1,296
Fluorescent Probes for Sensing and Imaging within Specific Cellular Organelles
Zhu, H., Fan, J., Du, J., & Peng, X. (2016) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00292 · Cited by 984
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells
Shibuya, N., Koike, S., Tanaka, M., Ishigami-Yuasa, M., Kimura, Y., Ogasawara, Y., Fukui, K., Nagahara, N., & Kimura, H. (2013) · Nature Communications · doi:10.1038/ncomms2371 · Cited by 558
Self-citationPhysiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
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Shields, H. J., Traa, A., & Van Raamsdonk, J. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628157 · Cited by 478
Metadata
- Authors
- Kimura, Y., Goto, Y.-I., & Kimura, H.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2010-01
- Volume
- 12
- Issue
- 1
- Pages
- 1-13
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2164663685
- Cited by
- 685
- References
- 56
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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