Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

Cites (406)

Items 201–400 of 406

1. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor
   Sun Yang, Kaikobad Irani, Susan E. Heffron, FRANCES A. JURNAK, Frank Louis Meyskens · 2005 · Molecular Cancer Therapeutics
2. Glucose Withdrawal Induces Oxidative Stress followed by Apoptosis in Glioblastoma Cells but not in Normal Human Astrocytes
   Nannette Jelluma, Xiaodong Yang, David Stokoe, Gérard I. Evan, Tobias B. Dansen, Daphne Adele Haas-Kogan · 2006 · Molecular Cancer Research
3. Glutathione disulfide induces apoptosis in U937 cells by a redox‐mediated p38 mitogen‐activated protein kinase pathway
   Giuseppe Filomeni, Giuseppe Rotilio, Maria Rosa Ciriolo · 2002 · The FASEB Journal
4. Vitamin E Analogs, a Novel Group of “Mitocans,” as Anticancer Agents: The Importance of Being Redox-Silent
   Jiřı́ Neužil, Marco Tomasetti, Yan Zhao, Lan‐Feng Dong, Marc Birringer, Xiufang Wang, Pauline Low, Kun Wu, Brian A. Salvatore, Stephen John Ralph · 2007 · Molecular Pharmacology
5. Mechanisms of Inhibition of the Thioredoxin Growth Factor System by Antitumor 2-Imidazolyl Disulfides
   D. Lynn Kirkpatrick, Miles Kuperus, Marla Dowdeswell, Noëlle Potier, Lynda J. Donald, Mark W. Kunkel, Margareta I. Berggren, Miguel Angulo, Garth Powis · 1998 · Biochemical Pharmacology
6. Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer
   Antonio Ramos‐Montoya, Wai‐Nang P. Lee, Sara Bassilian, Shu K. Lim, Raisa V. Trebukhina, M.V. Kazhyna, Carlos J. Ciudad, Verónique Noé, Josep J. Centelles, Marta Cascante · 2006 · International Journal of Cancer
7. Cancer chemoprevention: A radical perspective
   Numsen Hail, Marcela Cortes, Edgar N. Drake, Julian Ernest Spallholz · 2008 · Free Radical Biology and Medicine
8. Chemosensitization of Cancer In vitro and In vivo by Nitric Oxide Signaling
   Lisa J. Frederiksen, Richard Sullivan, Lori Maxwell, Shannyn K. Macdonald-Goodfellow, MICHAEL A. ADAMS, Brian M. Bennett, David Robert Siemens, Charles H. Graham · 2007 · Clinical Cancer Research
9. PX‐478, an inhibitor of hypoxia‐inducible factor‐1α, enhances radiosensitivity of prostate carcinoma cells
   Palayoor, Sanjeewani T., Mitchell, James B., Cerna, David, DeGraff, William, John‐Aryankalayil, Molykutty, Coleman, C. Norman · 2008 · International Journal of Cancer
10. Oxidative Inhibition of Receptor-type Protein-tyrosine Phosphatase κ by Ultraviolet Irradiation Activates Epidermal Growth Factor Receptor in Human Keratinocytes
    Yiru Xu, Yuan Shao, John J. Voorhees, Gary J. Fisher · 2006 · Journal of Biological Chemistry
11. Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide
    Steve K. W. Oh, Byung Ju Kim, Narendra Prasad Singh, Henry C. Lai, Tomikazu Sasaki · 2008 · Cancer Letters
12. Hypoxia Inducible Factor-2α in Cancer
    Tobias Löfstedt, E. Fredlund, Linda Holmquist-Mengelbier, Alexander Pietras, Marie Ovenberger, L. Poellinger, S. Påhlman · 2007 · Cell Cycle
13. The cancer cell’s “power plants” as promising therapeutic targets: An overview
    Peter L. Pedersen · 2007 · Journal of Bioenergetics and Biomembranes
14. Metabolic Targeting as an Anticancer Strategy: Dawn of a New Era?
    James G. Pan, Tak W. Mak · 2007 · Science s STKE
15. Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone.
    Meihua Luo, Mark R. Kelley · 2004 · PubMed
16. Identification and Validation of the Mitochondrial F1F0-ATPase as the Molecular Target of the Immunomodulatory Benzodiazepine Bz-423
    Kathryn M. Johnson, Xueni Chen, Anthony E. Boitano, Lara Swenson, Anthony W. Opipari, Gary D. Glick · 2005 · Chemistry & Biology
17. Tirapazamine: From Bench to Clinical Trials
    Loredana Gabriela Marcu, Ian Olver · 2006 · Current Clinical Pharmacology
18. Anti-HIV Agents That Selectively Target Retroviral Nucleocapsid Protein Zinc Fingers without Affecting Cellular Zinc Finger Proteins
    Mingjun Huang, Andrew T. Maynard, Jim A. Turpin · 1998 · Journal of Medicinal Chemistry
19. A Phase I/II Study of Arsenic Trioxide/Bortezomib/Ascorbic Acid Combination Therapy for the Treatment of Relapsed or Refractory Multiple Myeloma
    James R. Berenson, Jeffrey Matous, Regina A. Swift, Russell Mapes, Blake Morrison, Howard Yeh · 2007 · Clinical Cancer Research
20. Dithiocarbamate Toxicity toward Thymocytes Involves Their Copper-Catalyzed Conversion to Thiuram Disulfides, Which Oxidize Glutathione in a Redox Cycle without the Release of Reactive Oxygen Species
    Mark J. Burkitt, Hugh S. Bishop, Lesley Milne · 1998 · Archives of Biochemistry and Biophysics
21. Glycobiology and Cancer: Meeting Summary and Future Directions
    Gerald Warren Hart, John B. Lowe, Neeraja Sathyamoorthy · 2004 · Cancer Biology & Therapy
22. Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat
    James C. Moore, Henry C. Lai, Jian-Ren Li, Rulong Ren, John A. McDougall, Narendra Prasad Singh, Chung‐Kwang Chou · 1995 · Cancer Letters
23. Dimethylfumarate impairs melanoma growth and metastasis.
    R. Loewe, Teresa Valero, S. Kremling, Barbara Pratscher, R. Kunstfeld, H. Pehamberger, P. Petzelbauer · 2006 · Cancer Research
24. Phase I Clinical Trial of STA-4783 in Combination with Paclitaxel in Patients with Refractory Solid Tumors
    Anna Berkenblit, Joseph P. Eder, David P. Ryan, Michael V. Seiden, Noriaki Tatsuta, Matthew Leigh Sherman, Thomas A. Dahl, Bruce Jeffrey Dezube, Jeffrey G. Supko · 2007 · Clinical Cancer Research
25. Overview of recurrent respiratory papillomatosis
    Brian J. Wiatrak · 2003 · Current Opinion in Otolaryngology & Head & Neck Surgery
26. Pharmacologic Blockade of Angiopoietin-2 Is Efficacious against Model Hemangiomas in Mice
    Betsy N. Perry, Baskaran Govindarajan, Sulochana S. Bhandarkar, Ulla G. Knaus, Monika Valo, Celina Sturk, Carol O. Carrillo, Allie M. Sohn, Francesca Cerimele, Dan J. Dumont et al. · 2006 · Journal of Investigative Dermatology
27. Acrolein Inhibits Cytokine Gene Expression by Alkylating Cysteine and Arginine Residues in the NF-κB1 DNA Binding Domain
    Cherie L. Lambert, Jimei Li, Karen R. Jonscher, Teng‐Chieh Yang, Philip Reigan, Megan T. Quintana, Jean Harvey, Brian M. Freed · 2007 · Journal of Biological Chemistry
28. Glutathione S‐Transferases as Regulators of Kinase Pathways and Anticancer Drug Targets
    Danyelle M. Townsend, Victoria J. Findlay, Kenneth D. Tew · 2005 · Methods in enzymology on CD-ROM/Methods in enzymology
29. Tumor Cell Responses to a Novel Glutathione S-Transferase–Activated Nitric Oxide-Releasing Prodrug
    Victoria J. Findlay, Danyelle M. Townsend, Joseph E. Saavedra, Gregory S. Buzard, Michael L. Citro, Larry K. Keefer, Xinhua Ji, Kenneth D. Tew · 2004 · Molecular Pharmacology
30. Experimental therapeutics: targeting the redox Achilles heel of cancer.
    Christopher M. Cabello, Warner B. Bair, Georg T. Wondrak · 2007 · PubMed
31. Nox1 Redox Signaling Mediates Oncogenic Ras-induced Disruption of Stress Fibers and Focal Adhesions by Down-regulating Rho
    Masahiro Shinohara, Wei-Hao Shang, Makoto Kubodera, Saori Harada, Junji Mitsushita, Masayoshi Kato, Hitoshi Miyazaki, Hideke Sumimoto, Tohru Kamata · 2007 · Journal of Biological Chemistry
32. Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors
    Sarah A. Lowndes, Avril Adams, Anthony Timms et al. · 2008 · Clinical Cancer Research
33. Role of Reactive Oxygen Intermediates in Cellular Responses to Dietary Cancer Chemopreventive Agents
    Jędrzej Antosiewicz, Wiesław Ziółkowski, Siddhartha Kar, Anna A. Powolny, Shivendra Vikram Singh · 2008 · Planta Medica
34. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress
    Georg T. Wondrak, Christopher M. Cabello, Nicole F. Villeneuve, Shirley Zhang, Stephanie Ley, Yanjie Li, Zheng Sun, Donna D. Zhang · 2008 · Free Radical Biology and Medicine
35. Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
    Rui‐Hua Xu, Hélène Pelicano, H. Zhang · 2005 · Leukemia
36. The Anticancer Agent Chaetocin Is a Competitive Substrate and Inhibitor of Thioredoxin Reductase
    Jennifer D. Tibodeau, Linda M. Benson, Crescent R. Isham, Whyte G. Owen, Keith Christopher Bible · 2008 · Antioxidants and Redox Signaling
37. Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines
    Sharon Rozenblat, Shlomo Grossman, Margalit Bergman, Hugo Emilio Gottlieb, Yigal R. Cohen, Sara Dovrat · 2007 · Biochemical Pharmacology
38. Single-Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3,3′-Diindolylmethane in Healthy Subjects
    Gregory A. Reed, Jean M. Sunega, Debra K. Sullivan, John C. Gray, Matthew S. Mayo, James A. Crowell, Aryeh Hurwitz · 2008 · Cancer Epidemiology Biomarkers & Prevention
39. Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth
    Melissa L. Fishel, Ying He, April M. Reed · 2007 · DNA repair
40. Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism
    H Zhang, Dunyaporn Trachootham, Weiqin Lu, Jennifer S. Carew, Francis Joseph Giles, Michael J. Keating, Ralph B. Arlinghaus, Peng Huang · 2008 · Leukemia
41. Mitochondria as targets for cancer therapy
    Stephen John Ralph, Jiřı́ Neužil · 2009 · Molecular Nutrition & Food Research
42. Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells
    Ji Su Kim, Keun Jae Ahn, Jeong‐Ah Kim, Hye Mi Kim, Jong Doo Lee, Jae Myun Lee, Se‐Jong Kim, Jeon Han Park · 2008 · Journal of Bioenergetics and Biomembranes
43. The reactive oxygen‐driven tumor: relevance to melanoma
    Levi E. Fried, Jack L. Arbiser · 2008 · Pigment Cell & Melanoma Research
44. Characterization of a Mechanism-Based Inhibitor of NAD(P)H:Quinone Oxidoreductase 1 by Biochemical, X-ray Crystallographic, and Mass Spectrometric Approaches
    Shannon L. Winski, Margarita Faig, Mario A. Bianchet · 2001 · Biochemistry
45. Chemosensitization of Cancer by Nitric Oxide
    Richard Sullivan, Charles H. Graham · 2008 · Current Pharmaceutical Design
46. NOV-002, a Glutathione Disulfide Mimetic, as a Modulator of Cellular Redox Balance
    Townsend, Danyelle M., He, Lin, Hutchens, Steven, Garrett, Tracy E., Pazoles, Christopher J., Tew, Kenneth D. · 2008 · Cancer Research
47. A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells
    Benoît Boivin, Sheng Zhang, Jack L. Arbiser, Zhong‐Yin Zhang, Nicholas K. Tonks · 2008 · Proceedings of the National Academy of Sciences
48. Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line
    Takahisa Tarumoto, Tadashi Nagai, Ken Ohmine, Takuji Miyoshi, Makiko Nakamura, Takahito Kondo, Kenji Mitsugi, Syuji Nakano, Kazuo Muroi, Norio Komatsu et al. · 2004 · Experimental Hematology
49. Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)
    Marcel Kaiser, Sergio Wittlin, Angela Nehrbass-Stuedli · 2007 · Antimicrobial Agents and Chemotherapy
50. Pharmacologic or Genetic Manipulation of Glutathione S-Transferase P1–1 (GSTπ) Influences Cell Proliferation Pathways
    J E Ruscoe, Lilliam A. Rosario, Tieli Wang · 2001 · Journal of Pharmacology and Experimental Therapeutics
51. Induction of mitochondrial changes in myeloma cells by imexon
    Kateřina Dvořáková, Caroline N. Waltmire, Claire M. Payne · 2001 · Blood
52. Reactive oxygen species: an Achilles’ heel of melanoma?
    John P. Fruehauf, Valerie Trapp · 2008 · Expert Review of Anticancer Therapy
53. Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice
    Julien Verrax, Julie Stockis, Aurélie Tison · 2006 · Biochemical Pharmacology
54. PABA/NO as an Anticancer Lead: Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity
    Joseph E. Saavedra, Aloka Srinivasan, Gregory S. Buzard, Keith Maurice Davies, David J. Waterhouse, Keiko Inami, Thomas C. Wilde, Michael L. Citro, Matthew E. Cuellar, Jeffrey R. Deschamps et al. · 2006 · Journal of Medicinal Chemistry
55. The thioredoxin system: a key target in tumour and endothelial cells
    Abhik Mukherjee, Stewart G. Martin · 2008 · British Journal of Radiology
56. Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma
    Cu Nguyen, Jia-Ling Teo, Akihisa Matsuda, Masakatsu Eguchi, Emil Y. Chi, William R. Henderson, Michaël Kahn · 2003 · Proceedings of the National Academy of Sciences
57. The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma
    Baker, Amanda F., Dragovich, Tomislav, Tate, Wendy R., Ramanathan, Ramesh K., Roe, Denise, Hsu, Chiu-Hsieh, Kirkpatrick, D. Lynn, Powis, Garth · 2006 · Journal of Laboratory and Clinical Medicine
58. Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF‐κB
    Daizo Oka, Kazuo Nishimura, Masahiro Shiba, Yasutomo Nakai, Yasuyuki Arai, Masashi Nakayama, Hitoshi Takayama, Hitoshi Inoue, Äkïhïko Okuyama, Norio Nonomura · 2007 · International Journal of Cancer
59. Therapeutic advances in leukemia and myelodysplastic syndrome over the past 40 years
    Hagop M. Kantarjian, Susan Mary O'Brien, Jörge E. Cortes, William G. Wierda, Stefan H Faderl, Guillermo Garcia‐Manero, Jean‐Pierre J. Issa, Elihu H. Estey, Michael J. Keating, Emil J. Freireich · 2008 · Cancer
60. Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon
    Kateřina Dvořáková, Claire M. Payne, Margaret E. Tome, Margaret M. Briehl, Thomas D. McClure, Robert T. Dorr · 2000 · Biochemical Pharmacology
61. Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II
    Anna Kawiak, Jacek Piosik, Grzegorz Stasiłojć, Anna Gwizdek‐Wiśniewska, Łukasz Marczak, Maciej Stobiecki, Jacek Bigda, Ewa Łojkowska · 2007 · Toxicology and Applied Pharmacology
62. Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells
    Song Zhang, Juhong Yang, Chang-Kai Guo, Pengcheng Cai · 2007 · Cancer Letters
63. Role of antioxidant genes for the activity of artesunate against tumor cells
    Thomas Efferth, Margaret M. Briehl, Margaret E. Tome · 2003 · International Journal of Oncology
64. Vitamin E Succinate Inhibits Colon Cancer Liver Metastases
    Kevin T. Barnett, Frida D. Fokum, Mokenge Peter Malafa · 2002 · Journal of Surgical Research
65. Crystal structure of γ-glutamylcysteine synthetase: Insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
    Takao Hibi, Hiroshi Nii, Toru Nakatsu · 2004 · Proceedings of the National Academy of Sciences
66. A Phase II study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and gemcitabine in advanced pancreatic carcinoma. A trial of the Princess Margaret Hospital Phase II consortium
    Mary J. MacKenzie, David L. Saltman, Hal W. Hirte, Jennifer A. Low, C. Johnson, Gregory R. Pond, Malcolm J. Moore · 2007 · Investigational New Drugs
67. Synthesis, Structure, Electrochemistry, and Spectral Characterization of Bis-Isatin Thiocarbohydrazone Metal Complexes and Their Antitumor Activity Against Ehrlich Ascites Carcinoma in Swiss Albino Mice
    M. P. Sathisha, Vidyanand Krishna Revankar, Karkala Sreedhara Ranganath Pai · 2007 · Metal-Based Drugs
68. Elucidation of Thioredoxin as a Molecular Target for Antitumor Quinols
    Tracey Dawn Bradshaw, Charles S. Matthews, Jennifer C. Cookson, Eng‐Hui Chew, Manish A. Shah, Kevin Bailey, Anne P. Monks, Erik D. Harris, Andrew D. Westwell, Geoffrey Wells et al. · 2005 · Cancer Research
69. Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase
    Ha‐Won Jeong, Dong Cho Han, Kwang‐Hee Son · 2003 · Biochemical Pharmacology
70. Treatment of Pancreatic Cancer Cells with Dicumarol Induces Cytotoxicity and Oxidative Stress
    Anne Marie Lewis, Matthew Ough, Ling Li, Marilyn M. Hinkhouse, Justine M. Ritchie, Douglas R. Spitz, Joseph J. Cullen · 2004 · Clinical Cancer Research
71. Efficacy of 2-halogen substituted d-glucose analogs in blocking glycolysis and killing “hypoxic tumor cells”
    Théodore J. Lampidis, Metin Kurtoğlu, Johnathan C. Maher, Huaping Liu, Awtar Krishan, Valerie Sheft, Sławomir Szymański, Izabela Fokt, Witold Remigiusz Rudnicki, Krzysztof Ginalski et al. · 2006 · Cancer Chemotherapy and Pharmacology
72. Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)
    Fernando Doñate, J. Juárez, Mark E. Burnett, Mari Manuia, X Guan, David Elliot Shaw, Eric L. Smith, Ahmet Can Timuçin, Marc Justin Braunstein, Olcay Batuman et al. · 2008 · British Journal of Cancer
73. Generation of reactive oxygen species by a persulfide (BnSSH)
    Tonika Chatterji, Kripa Keerthi, Kent S. Gates · 2005 · Bioorganic & Medicinal Chemistry Letters
74. Gliotoxin inactivates alcohol dehydrogenase by either covalent modification or free radical damage mediated by redox cycling
    Paul Waring, Allan Sjaarda, Qing H. Lin · 1995 · Biochemical Pharmacology
75. The ROS-NOX Connection in Cancer and Angiogenesis
    Christophe Blanchetot, Johannes Boonstra · 2008 · Critical Reviews in Eukaryotic Gene Expression
76. Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
    Lihua Wang, Xiao Yi Yang, Xiaohu Zhang · 2003 · Nature Medicine
77. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice
    Dominika Nowis, Marek Bugajski, Magdalena Winiarska et al. · 2008 · BMC Cancer
78. Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer
    M Földi, Elmar Stickeler, Lidija Annecke Bau, Oliver Kretz, Dirk Otto Watermann, Gerald Gitsch, Gian Kayser, Axel zur Hausen, Johannes Coy · 2007 · Oncology Reports
79. Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer.
    Li-Hua Wang, Xiao-Yi Yang, Xiaohu Zhang, P. An, Han-Jong Kim, Jiaqiang Huang, R. Clarke, C. Osborne, J. Inman, E. Appella et al. · 2006 · Cancer Cell
80. Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents
    Eriko Simamura, Hiroki Shimada, Toshihisa Hatta, Kei‐Ichi Hirai · 2008 · Journal of Bioenergetics and Biomembranes
81. Coumarin-Based Inhibitors of Human NAD(P)H:Quinone Oxidoreductase-1. Identification, Structure–Activity, Off-Target Effects and In Vitro Human Pancreatic Cancer Toxicity
    Karen Ann Nolan, He Zhao, Paul Faulder, A. David Frenkel, David J. Timson, David M. Siegel, David Ross, Terrence R. Burke, Ian James Stratford, Richard A. Bryce · 2007 · Journal of Medicinal Chemistry
82. In Vitro Screening Techniques for Reactive Metabolites for Minimizing Bioactivation Potential in Drug Discovery
    Chandra Prakash, Raman Sharma, Michelle Gleave, Angus Nedderman · 2008 · Current Drug Metabolism
83. Drug-Mediated Targeted Disruption of Multiple Protein Activities Through Functional Inhibition of the Hsp90 Chaperone Complex
    Stravopodis, Dimitrios, Margaritis, Lukas, Voutsinas, Gerassimos · 2007 · Current Medicinal Chemistry
84. Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective Cytotoxins
    Michael P. Hay, Kevin Owen Hicks, Karin Pchalek, Ho H. Lee, Adrian Blaser, Frederik B. Pruijn, Robert F. Anderson, Sujata S. Shinde, William Robert Wilson, William Alexander Denny · 2008 · Journal of Medicinal Chemistry
85. 2-Methoxyestradiol Does Not Inhibit Superoxide Dismutase
    Rémy Kachadourian, Stefan I. Liochev, Diane E. Cabelli, Manisha N. Patel, Irwin Fridovich, Brian J. Day · 2001 · Archives of Biochemistry and Biophysics
86. Chemical Stability of the Peroxide Bond Enables Diversified Synthesis of Potent Tetraoxane Antimalarials
    Igor Opsenica, Dejan Opsenica, Kirsten S. Smith · 2008 · Journal of Medicinal Chemistry
87. Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides
    Jason Lau, Krista L Weatherdon, Violetta Skalski · 2004 · British Journal of Cancer
88. Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates
    Kristin Brown, Sofi E. Eriksson, Elias S.J. Arnér, Mark B. Hampton · 2008 · Free Radical Biology and Medicine
89. A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects
    Wolfram E. Samlowski, Ryan Petersen, Salvatore Cuzzocrea, Heather Macarthur, Damali Burton, John R McGregor, Daniela Salvemini · 2003 · Nature Medicine
90. Imaging of tumor glucose utilization with positron emission tomography
    Andrea Bürkle, Wolfgang Weber · 2008 · Cancer and Metastasis Reviews
91. Mitochondrial drugs
    Peter L. Toogood · 2008 · Current Opinion in Chemical Biology
92. Mitochondrial Production of Reactive Oxygen Species Mediate Dicumarol-induced Cytotoxicity in Cancer Cells
    Juan Du, David H. Daniels, Carla Asbury, Sujatha Venkataraman, Jingru Liu, Douglas R. Spitz, Larry W. Oberley, Joseph J. Cullen · 2006 · Journal of Biological Chemistry
93. Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism
    Antonio Lavecchia, Sandro Cosconati, Vittorio Limongelli, Ettore Novellino · 2006 · ChemMedChem
94. Modulation of Reactive Oxygen Species in Pancreatic Cancer
    Melissa L.T. Teoh-Fitzgerald, Wenqing Sun, Brian J. Smith, Larry W. Oberley, Joseph J. Cullen · 2007 · Clinical Cancer Research
95. Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase
    Garth Powis, Peter Wipf, Stephen M. Lynch, Anne Birmingham, D. Lynn Kirkpatrick · 2006 · Molecular Cancer Therapeutics
96. Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
    Eileen M. Hoke, Caroline A. Maylock, Emily B. Shacter · 2005 · Free Radical Biology and Medicine
97. Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant
    Nuri Gueven, John Luff, Cheng Peng, Kazuyuki Hosokawa, Steven E. Bottle, Martin Francis Lavin · 2006 · Free Radical Biology and Medicine
98. The mechanism of action of nitric oxide-donating aspirin
    Khosrow Kashfi, Basil Rigas · 2007 · Biochemical and Biophysical Research Communications
99. Apoptosis induction of 2′-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells
    Su Hyung Hong, Jina Kim, Jung Min Kim, So‐Young Lee, Dae‐Seop Shin, Kwang‐Hee Son, Dong Cho Han, Young Kwan Sung, Byoung‐Mog Kwon · 2007 · Biochemical Pharmacology
100. Motexafin Gadolinium Disrupts Zinc Metabolism in Human Cancer Cell Lines
     Darren J. Magda, Philip S. Lecane, Richard A. Miller et al. · 2005 · Cancer Research
101. Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1α activation in C6 glioma cells
     Xiao-Jia Huang, Zhen-Qiu Ma, Weiping Zhang, Yun‐Bi Lu, Er-Qing Wei · 2007 · Journal of Pharmacy and Pharmacology
102. Identification, Synthesis, and Enzymology of Non‐natural Glucosinolate Chemopreventive Candidates
     Jared R. Mays, Rachel L. Weller, Sami Sarfaraz, Hasan Mukhtar, Scott R. Rajski · 2008 · ChemBioChem
103. Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells.
     M Adachi, Hiroki Sakamoto, Ryota Kawamura, W. Wang, Koji Imai, Yasuhisa Shinomura · 2007 · PubMed
104. Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands
     Paul V. Bernhardt, Gregory J. Wilson, Philip C. Sharpe, Danuta S. Kalinowski, Des Raymond Richardson · 2007 · JBIC Journal of Biological Inorganic Chemistry
105. Reaction of the Hypoxia-Selective Antitumor Agent Tirapazamine with a C1‘-Radical in Single-Stranded and Double-Stranded DNA: The Drug and Its Metabolites Can Serve as Surrogates for Molecular Oxygen in Radical-Mediated DNA Damage Reactions
     Jae-Taeg Hwang, Marc M. Greenberg, Tarra Fuchs-Knotts, Kent S. Gates · 1999 · Biochemistry
106. NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosis
     Georg T. Wondrak · 2007 · Free Radical Biology and Medicine
107. Optimized Clostridium -Directed Enzyme Prodrug Therapy Improves the Antitumor Activity of the Novel DNA Cross-Linking Agent PR-104
     Shie-Chau Liu, G‐One Ahn, Mitomu Kioi, Mary-Jo Dorie, Adam Vorn Patterson, J. Martin Brown · 2008 · Cancer Research
108. DNA cleavage by 7-methylbenzopentathiepin: A simple analog of the antitumor antibiotic varacin
     Tonika Chatterji, Kent S. Gates · 1998 · Bioorganic & Medicinal Chemistry Letters
109. Further insights into the mechanism of the reaction of activated bleomycin with DNA
     Marina S. Chow, Lei V. Liu, Edward I. Solomon · 2008 · Proceedings of the National Academy of Sciences
110. Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1
     Eugene A. Konorev, Srigiridhar Kotamraju, Hongtao Zhao · 2002 · Free Radical Biology and Medicine
111. The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H:Quinone Oxidoreductase 1 to More Potent Heat Shock Protein 90 Inhibitors, the Hydroquinone Ansamycins
     Wenchang Guo, Philip Reigan, David M. Siegel, Joseph A. Zirrolli, Daniel L. Gustafson, David Ross · 2006 · Molecular Pharmacology
112. Anti-tumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice
     Zhimian Zhang, Xiaoyun Yang, Deng Shu-hai · 2007 · Chinese Medical Journal
113. Structure–activity relationships for hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated esters, acrylates and methacrylates
     Katie Chan, Peter James O'Brien · 2008 · Journal of Applied Toxicology
114. Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors
     Allen A. Thomas, Yvan Le Huérou, Jason De Meese et al. · 2007 · Bioorganic & Medicinal Chemistry Letters
115. Methylene blue directly oxidizes glutathione without the intermediate formation of hydrogen peroxide.
     Kelner Mj, N M Alexander · 1985 · Journal of Biological Chemistry
116. On the Origin of Cytotoxicity of the Natural Product Varacin. A Novel Example of a Pentathiepin Reaction That Provides Evidence for a Triatomic Sulfur Intermediate
     Alexander Greer · 2001 · Journal of the American Chemical Society
117. Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase
     FYH WU, Ter-Ping Sun · 1999 · European Journal of Cancer
118. Quinols as Novel Therapeutic Agents. 2. 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and Related Agents as Potent and Selective Antitumor Agents
     Jane M. Berry, Tracey Dawn Bradshaw, Iduna Fichtner, Ruobo Ren, Carl H. Schwalbe, Geoffrey Wells, Eng‐Hui Chew, Malcolm F. G. Stevens, Andrew D. Westwell · 2004 · Journal of Medicinal Chemistry
119. Targeting superoxide dismutase 1 to overcome cisplatin resistance in human ovarian cancer
     Dawn P. G. Brown, Helen Chin-Sinex, Bei Nie, Marc S. Mendonca, Mu Wang · 2008 · Cancer Chemotherapy and Pharmacology
120. Cell Cycle Regulation by Oncogenic Tyrosine Kinases in Myeloid Neoplasias: From Molecular Redox Mechanisms to Health Implications
     Margret S. Rodrigues, Mamatha M. Reddy, Martin Sattler · 2008 · Antioxidants and Redox Signaling
121. Commentary: Novel Therapies for Cancer: Why Dirty Might Be Better
     Tito Fojo · 2008 · The Oncologist
122. Phase I Trial of Imexon in Patients With Advanced Malignancy
     Tomislav Dragovich, Michael S. Gordon, David S. Mendelson, Lucas Wong, Manuel Modiano, H.‐H. Sherry Chow, Betty K. Samulitis, Steven J O'Day, Kathryn Grenier, Evan M. Hersh et al. · 2007 · Journal of Clinical Oncology
123. Development of Indolequinone Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1): NQO1 Inhibition and Growth Inhibitory Activity in Human Pancreatic MIA PaCa-2 Cancer Cells
     Philip Reigan, Marie A. Colucci, David M. Siegel · 2007 · Biochemistry
124. Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice
     Simeng Suy, James B. Mitchell, Ayelet M. Samuni, Susette C. Mueller, Usha N. Kasid · 2005 · Cancer
125. A Phase 1 Open-Label, Accelerated Dose-Escalation Study of the Hypoxia-Activated Prodrug AQ4N in Patients with Advanced Malignancies
     Kyriakos P. Papadopoulos, Sanjay Goel, Murali Beeram, Alvin Wong, Kavita K. Desai, Missak Haigentz, María L. Milián, Sridhar Mani, Anthony W. Tolcher, Alshad S. Lalani et al. · 2008 · Clinical Cancer Research
126. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1–mediated MDR in small cell lung cancer
     Giuseppe Filomeni, Paola Turella, Maria Luisa Dupuis · 2008 · Molecular Cancer Therapeutics
127. Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice
     Ralph E. Durand, Peggy L. Olive · 1997 · Radiation Oncology Investigations
128. Identification of Thioredoxin-Interacting Protein 1 as a Hypoxia-Inducible Factor 1α-Induced Gene in Pancreatic Cancer
     Amanda F. Baker, Mei Yee Koh, Ryan R. Williams, Brian P. James, Huamin Wang, Wendy R. Tate, Alfred C. Gallegos, Daniel D. Von Hoff, Haiyong Han, Garth Powis · 2008 · Pancreas
129. Gemtuzumab ozogamicin: an anti-CD33 immunoconjugate for the treatment of acute myeloid leukaemia
     Roberto Stasi · 2008 · Expert Opinion on Biological Therapy
130. Chemical Basis for the Biological Activity of Imexon and Related Cyanoaziridines
     Bhashyam S. Iyengar, Robert T. Dorr, William A. Remers · 2003 · Journal of Medicinal Chemistry
131. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: An anticancer agent targeting hypoxic cells
     Helen A. Seow, Philip G. Penketh, Krishnamurthy Shyam · 2005 · Proceedings of the National Academy of Sciences
132. Novel agents for cancer prevention based on nitric oxide
     Basil Rigas · 2007 · Biochemical Society Transactions
133. Redox catalysts as sensitisers towards oxidative stress
     Niroshini M. Giles, Nick J Gutowski, Gregory Ian Giles, Claus Jacob · 2003 · FEBS Letters
134. Phase II trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases
     Timothy E. Bael, Bercedis L. Peterson, Jared Gollob · 2008 · Melanoma Research
135. Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells
     Giuseppe Filomeni, Katia Aquilano, P. Civitareale, Giuseppe Rotilio, Maria Rosa Ciriolo · 2005 · Free Radical Biology and Medicine
136. Targeting Hypoxia-inducible Factor-1α With Tf–PEI–shRNA Complex via Transferrin Receptor–mediated Endocytosis Inhibits Melanoma Growth
     Yeqiang Liu, Juan Tao, Yan Li, Jing Xiang Yang, Yan Yu, Min Wang, Xiaoyuan Xu, Changzheng Huang, Wei Huang, Jing Dong et al. · 2008 · Molecular Therapy
137. Inactivation of the human papillomavirus-16 e6 oncoprotein by organic disulfides
     Walter Beerheide, Mui Mui Sim, Yee‐Joo Tan · 2000 · Bioorganic & Medicinal Chemistry
138. Multifunctional redox catalysts as selective enhancers of oxidative stress
     Fiona H. FryThese authors contributed equall, Andrea Lisa Holme, Niroshini M. Giles et al. · 2005 · Organic & Biomolecular Chemistry
139. Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells
     Takashi Hosono, Tomomi Hosono-Fukao, Kahoru Inada, Rie Tanaka, Haruhisa Yamada, Yuji Iitsuka, T. Seki, Isao Hasegawa, T. Ariga · 2008 · Carcinogenesis
140. Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system
     Hee Shim Choi, Joong Sup Shim, Ju-A Kim, Sang Won Kang, Ho Jeong Kwon · 2007 · Biochemical and Biophysical Research Communications
141. Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity
     Eng‐Hui Chew, Jun Lu, Tracey Dawn Bradshaw, Arne Holmgren · 2008 · The FASEB Journal
142. Small Molecules That Mimic the Thiol-Triggered Alkylating Properties Seen in the Natural Product Leinamycin
     Tonika Chatterji, Murat Kizil, Kripa Keerthi · 2003 · Journal of the American Chemical Society
143. Respiratory Chain-Generated Oxidative Stress Following Treatment of Leukemic Blasts with DNA-Damaging Agents
     Nhu‐An Pham, David William Hedley · 2001 · Experimental Cell Research
144. Bcl-2 and Mn-SOD Antisense Oligodeoxynucleotides and a Glutamine-enriched Diet Facilitate Elimination of Highly Resistant B16 Melanoma Cells by Tumor Necrosis Factor-α and Chemotherapy
     María Benlloch, Salvador Mena, Paula Ferrer, Elena Obrador, Miguel Angel Asensi, José A. Pellicer, Julián Carretero, Ángel Ortega, José M. Estrela · 2005 · Journal of Biological Chemistry
145. PM-20, a novel inhibitor of Cdc25A, induces extracellular signal–regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo
     Siddhartha Kar, Meifang Wang, Yao Wei · 2006 · Molecular Cancer Therapeutics
146. Application of structure–activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated aldehydes
     Katie Chan, Raymond W.M. Poon, Peter J. O’Brien · 2008 · Journal of Applied Toxicology
147. A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines
     Zuanel Diaz, Koren Kathleen Mann, Sophie Marcoux, Maria Kourelis, Myrian Colombo, Philip B. Komarnitsky, Wilson H. Miller · 2008 · Leukemia
148. Influx of Calcium through a Redox-sensitive Plasma Membrane Channel in Thymocytes Causes Early Necrotic Cell Death Induced by the Epipolythiodioxopiperazine Toxins
     Alanna M. Hurne, Christina L. L. Chai, Katherine Moerman, Paul Waring · 2002 · Journal of Biological Chemistry
149. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase
     P. Lei, Maen Abdelrahim, S. D. Cho, S. Liu, Sudhakar R. Chintharlapalli, Stephen H Safe · 2008 · Carcinogenesis
150. Ascorbic acid and cell survival of adriamycin resistant and sensitive MCF-7 breast tumor cells
     William W. Wells, Pamela A. Rocque, Dian-Peng Xu, Elizabeta B. Meyer, Leigh J. Charamella, Nikolay V. Dimitrov · 1995 · Free Radical Biology and Medicine
151. A Large Cohort Study of Nonsteroidal Anti-inflammatory Drug Use and Melanoma Incidence
     Maryam M. Asgari, Sonia S. Maruti, Emily White · 2008 · JNCI Journal of the National Cancer Institute
152. Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms
     Sharmila Shankar, Qinghe Chen, Suthakar Ganapathy · 2008 · Molecular Cancer Therapeutics
153. Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma
     Jedd D. Wolchok, Linda Jane Williams, John T. Pinto · 2003 · Melanoma Research
154. Cysteine-modifying agents: a possible approach for effective anticancer and antiviral drugs.
     Angela Casini, Andrea Scozzafava, Claudiu Trandafir Supuran · 2002 · Environmental Health Perspectives
155. Hypoxia-Selective 3-Alkyl 1,2,4-Benzotriazine 1,4-Dioxides: The Influence of Hydrogen Bond Donors on Extravascular Transport and Antitumor Activity
     Michael P. Hay, Karin Pchalek, Frederik B. Pruijn, Kevin Owen Hicks, Bronwyn G. Siim, Robert F. Anderson, Sujata S. Shinde, Victoria Phillips, William Alexander Denny, William Robert Wilson · 2007 · Journal of Medicinal Chemistry
156. Regulation of the cell cycle in response to inhibition of mitochondrial generated energy
     Adam Gemin, Susan Sweet, Tom J. Preston, Gurmit Singh · 2005 · Biochemical and Biophysical Research Communications
157. New Perspectives on Melanoma Pathogenesis and Chemoprevention
     Frank Louis Meyskens, Patrick J. Farmer, Sun Yang, Hoda Anton‐Culver · 2007 · Recent results in cancer research/Recent Results in Cancer Research
158. Vitamin E analogues as mitochondria‐targeting compounds: From the bench to the bedside?
     Yan Zhao, Jiřı́ Neužil, Kun Wu · 2008 · Molecular Nutrition & Food Research
159. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo
     Donna L. Dehn, David M. Siegel, Khan Shoeb Zafar · 2006 · Molecular Cancer Therapeutics
160. Mechanistic Basis for Therapeutic Targeting of the Mitochondrial F1Fo-ATPase
     Kathryn M. Johnson, Joanne Cleary, Carol A. Fierke, Anthony W. Opipari, Gary D. Glick · 2006 · ACS Chemical Biology
161. 2-Methoxyoestradiol-3,17-O,O-bis-sulphamate and 2-deoxy-D-glucose in combination: a potential treatment for breast and prostate cancer
     Sarah Tagg, Paul Foster, Mathew P. Leese · 2008 · British Journal of Cancer
162. In Vivo Antiviral Activity of Novel Human Immunodeficiency Virus Type 1 Nucleocapsid p7 Zinc Finger Inhibitors in a Transgenic Murine Model
     Marco L. Schito, Atul Goel, Yongsheng Song · 2003 · AIDS Research and Human Retroviruses
163. Biochemical Mechanism of Acetaminophen (APAP) Induced Toxicity in Melanoma Cell Lines
     Nikhil M. Vad, Garret L. Yount, Dan Moore · 2008 · Journal of Pharmaceutical Sciences
164. Directed Biosynthesis of Fluorinated Pseurotin A, Synerazol and Gliotoxin
     Yasuhiro Igarashi, YUKIHIRO YABUTA, Akira Sekine · 2004 · The Journal of Antibiotics
165. Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species–mediated damage
     Se-Yeong Oh, Young-Woo Sohn, Jong‐Whi Park, Hyo‐Jung Park, Hye-Min Jeon, Tae-Kyung Kim, Joong-Seob Lee, Jieun Jung, Xun Jin, Yong Gu Chung et al. · 2007 · Molecular Cancer Therapeutics
166. Oxidative Stress Plays a Critical Role in Inactivating Mutant BRAF by Geldanamycin Derivatives
     Yayoi Fukuyo, Masahiro Inoue, Takuma Nakajima, Ryuji Higashikubo, Nobuko T. Horikoshi, Clayton R. Hunt, Anny Usheva, Michael L. Freeman, Nobuo Horikoshi · 2008 · Cancer Research
167. HIF2α reduces growth rate but promotes angiogenesis in a mouse model of neuroblastoma
     Judith Favier, Stéphanie Lapointe, Ricardo Maliba, Martin G. Sirois · 2007 · BMC Cancer
168. Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study
     JE Chang, PM Voorhees, JM Kolesar · 2008 · Hematological Oncology
169. Targeting of VX2 Rabbit Liver Tumor by Selective Delivery of 3-Bromopyruvate: A Biodistribution and Survival Study
     Mustafa Vali, Josephina Anna Vossen, Manon Buijs et al. · 2008 · Journal of Pharmacology and Experimental Therapeutics
170. Cdc25B Phosphatase Inhibitors in Cancer Therapy: Latest Developments, Trends and Medicinal Chemistry Perspective
     Antonio Lavecchia, Antonio Coluccia, Carmen Di Giovanni · 2008 · Anti-Cancer Agents in Medicinal Chemistry
171. Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines
     Nikhil M. Vad, Garret L. Yount, Majid Y. Moridani · 2008 · Melanoma Research
172. Catalase reverses tumorigenicity in a malignant cell line by an epidermal growth factor receptor pathway
     Joanne S. Finch, Margaret E. Tome, Kevin A. Kwei, G. Tim Bowden · 2005 · Free Radical Biology and Medicine
173. Selective and Synergistic Activity of L‐S,R‐Buthionine Sulfoximine on Malignant Melanoma Is Accompanied by Decreased Expression of Glutathione‐S‐Transferase
     John P. Fruehauf, Svetlana Zonis, M N Al-Bassam, Ainura S. Kyshtoobayeva, Chiranjib Dasgupta, Tatjana Milovanović, Ricardo J. Parker, Antonio Carlos Buzaid · 1997 · Pigment Cell Research
174. Inhibition of Glutathione Synthesis Overcomes Bcl-2-Mediated Topoisomerase Inhibitor Resistance and Induces Nonapoptotic Cell Death via Mitochondrial-Independent Pathway
     Akira Yoshida, Haruyuki Takemura, Hitoshi Inoue, Toshiyuki Miyashita, Takanori Ueda · 2006 · Cancer Research
175. Redox active disulfides: the thioredoxin system as a drug target.
     Kirkpatrick Dl, G Ehrmantraut, S Stettner · 1997 · PubMed
176. Methylene blue is more toxic to erythroleukemic cells than to normal peripheral blood mononuclear cells: a possible use in chemotherapy
     Clarice Kirszberg, V. M. Rumjanek, Márcia Alves Marques Capella · 2005 · Cancer Chemotherapy and Pharmacology
177. A cellular and molecular investigation of the action of PMX464, a putative thioredoxin inhibitor, in normal and colorectal cancer cell lines
     Abhik Mukherjee, K Huber, H Evans · 2007 · British Journal of Pharmacology
178. Pharmacology of a mimetic of glutathione disulfide, NOV-002
     Danyelle M. Townsend, Kenneth D. Tew · 2008 · Biomedicine & Pharmacotherapy
179. NCI sets goal of eliminating suffering and death due to cancer by 2015.
     Andrew C. von Eschenbach · 2003 · PubMed
180. Inhibition of Thioredoxin Reductase by Curcumin Analogs
     Zhong Liu, Zhiyun Du, Zhi‐Shu Huang, Kin-Sing Lee, Lian‐Quan Gu · 2008 · Bioscience Biotechnology and Biochemistry
181. Targeting Disseminated Melanoma with Radiolabelled Methylene Blue: Comparative bio-distribution studies in man and animals
     Eva M. Link, Durval C. Costa, Dominic Lui · 1996 · Acta Oncologica
182. Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3′-indolyl)methane (DIM) and 5,5′-dibromoDIM
     Kathy Vanderlaag, Ismael J. Samudio, Robert C. Burghardt · 2005 · Cancer Letters
183. Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd)
     Farnaz Zahedi Avval, Carsten Berndt, Aladdin Pramanik, Arne Holmgren · 2009 · Biochemical and Biophysical Research Communications
184. Superoxide dismutase as a target enzyme for Fe-porphyrin-induced cell death
     Shoichiro Asayama, Nobuyoshi Kasugai, Sunao Kubota · 2006 · Journal of Inorganic Biochemistry
185. Motexafin Gadolinium for the Treatment of Metastatic Renal Cell Carcinoma: Phase II Study Results
     Robert John Amato, Jaroslaw Jac, Joan Hernandez-McClain · 2008 · Clinical Genitourinary Cancer
186. The Antitumor Agent Imexon Activates Antioxidant Gene Expression: Evidence for an Oxidative Stress Response
     Amanda F. Baker, Terry H. Landowski, Robert T. Dorr · 2007 · Clinical Cancer Research
187. Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of vitamin E analog for cancer prevention.
     Yue Wu, Ke Zu, Jing Ni, Shuyuan Yeh, Dhanalakshmi Kasi, Nadine S. James, Sherry R. Chemler, Clement C.Y. Ip · 2004 · PubMed
188. Chemical and Clinical Development of Darinaparsin, a Novel Organic Arsenic Derivative
     Alfonso Quintás‐Cardama, Srđan Verstovšek, Emil J. Freireich, Hagop M. Kantarjian, Yi Wen Chen, Ralph A. Zingaro · 2008 · Anti-Cancer Agents in Medicinal Chemistry
189. Comparison of diarsenic oxide and tetraarsenic oxide on anticancer effects: Relation to the apoptosis molecular pathway
     Hong-Seok Chang, Su-Mi Bae, Yong‐Wan Kim, Sun‐Young Kwak, Hyun-Jin Min, IL-Ju Bae, Young‐Joo Lee, Jong‐Chul Shin, Chong‐Kook Kim, Woong‐Shick Ahn · 2007 · International Journal of Oncology
190. Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284).
     Jianxia Guo, Robert A. Parise, Erin Joseph · 2007 · PubMed
191. PKC Sulfhydryl Targeting by Disulfiram Produces Divergent Isozymic Regulatory Responses that Accord with the Cancer Preventive Activity of the Thiuram Disulfide
     Feng Chu, Catherine A. O’Brian · 2005 · Antioxidants and Redox Signaling
192. Role of NADPH cytochrome P450 reductase in activation of RH1
     Asher Begleiter, Marsha K. Leith, Daywin Patel · 2007 · Cancer Chemotherapy and Pharmacology
193. 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1 H-benzo[b][1,4]diazepin-2(3 H)-one (Bz-423), a Benzodiazepine, Suppresses Keratinocyte Proliferation and Has Antipsoriatic Activity in the Human Skin-Severe, Combined Immunodeficient Mouse Transplant Model
     Narasimharao Bhagavathula, Kamalakar C. Nerusu, Andrew W. Hanosh · 2007 · Journal of Pharmacology and Experimental Therapeutics
194. Motexafin gadolinium induces oxidative stress and apoptosis in hematologic malignancies
     Andrew M. Evens, Lakshmi Balasubramanian, Leo I. Gordon · 2005 · Current Treatment Options in Oncology
195. Electromicroscopic observations on gliotoxin-induced apoptosis of cancer cells in culture and human cancer xenografts in transplanted SCID mice.
     Xing Qing Pan, John Harday · 2007 · PubMed
196. Apurinic/Apyrimidinic Endonuclease/Redox Effector Factor-1(APE/Ref-1): A Unique Target for the Prevention and Treatment of Human Melanoma
     Sun Yang, Frank Louis Meyskens · 2008 · Antioxidants and Redox Signaling
197. Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin
     Santhosh Sivaramakrishnan, Kent S. Gates · 2007 · Bioorganic & Medicinal Chemistry Letters
198. PMX464, a thiol‐reactive quinol and putative thioredoxin inhibitor, inhibits NF‐κB‐dependent proinflammatory activation of alveolar epithelial cells
     Matthew E.J. Callister, Liao Pinhu, Matthew C. Catley, Andrew D. Westwell, Robert Charles Newton, Susannah K. Leaver, Gregory J. Quinlan, Timothy W. Evans, Mark Griffiths, Anne C. Burke-Gaffney · 2008 · British Journal of Pharmacology
199. Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice
     Alan Pourpak, Ross O. Meyers, Betty K. Samulitis · 2006 · Anti-Cancer Drugs
200. Triethylene tetramine, a novel ligand of G-quadruplex, induces senescence of MCF-7 cells
     Guo Li-xia, Fei Yin, Jiajia Jing, Jianhui Liu · 2007 · Biotechnology Letters