Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities
Open accessAbstract
Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by redox chemotherapeutics. This review will present an update on drug discovery, target identification, and mechanisms of action of experimental redox chemotherapeutics with a focus on pro- and antioxidant redox modulators now in advanced phases of preclinal and clinical development. Recent research indicates that numerous oncogenes and tumor suppressor genes exert their functions in part through redox mechanisms amenable to pharmacological intervention by redox chemotherapeutics. The pleiotropic action of many redox chemotherapeutics that involves simultaneous modulation of multiple redox sensitive targets can overcome cancer cell drug resistance originating from redundancy of oncogenic signaling and rapid mutation.Moreover, some redox chemotherapeutics may function according to the concept of synthetic lethality (i.e., drug cytotoxicity is confined to cancer cells that display loss of function mutations in tumor suppressor genes or upregulation of oncogene expression). The impressive number of ongoing clinical trials that examine therapeutic performance of novel redox drugs in cancer patients demonstrates that redox chemotherapy has made the crucial transition from bench to bedside.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Existing pro-oxidant cancer therapies frequently damage healthy tissue and have a small therapeutic window.
“current pro-oxidant strategies often cause serious collateral damage, resulting in a narrow therapeutic window20”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [20]
Cites
2 retracted
Suliman, H. B., Carraway, M. S., Ali, A. S., Reynolds, C. M., Welty‐Wolf, K. E., & Piantadosi, C. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32967 · Cited by 255 · see citing works
RetractedGong, X., Kole, L., Iskander, K. S., & Jaiswal, A. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0323 · Cited by 107 · see citing works
RetractedSchafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587 · see citing works
Targeting cancer with small molecule kinase inhibitors
Zhang, J., Yang, P. L., & Gray, N. S. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2559 · Cited by 2,586 · see citing works
Production of large amounts of hydrogen peroxide by human tumor cells.
Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,504 · see citing works
Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1
Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377 · see citing works
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works
Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876 · see citing works
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781 · see citing works
p53 Regulates Mitochondrial Respiration
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650 · see citing works
RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels
Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631 · see citing works
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588 · see citing works
Bonnet, S., Archer, S. L., Allalunis‐Turner, J., Haromy, A., Beaulieu, C., Thompson, R. B., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S. B., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.020 · Cited by 1,530 · see citing works
Glycolysis inhibition for anticancer treatment
Pelicano, H., Martin, D. S., Xu, R., & Huang, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209597 · Cited by 1,516 · see citing works
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480 · see citing works
Dolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446 · see citing works
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
Kaelin, W. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1691 · Cited by 1,369 · see citing works
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., & Kurzrock, R. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0024 · Cited by 1,337 · see citing works
Acute promyelocytic leukemia: from highly fatal to highly curable
Wang, Z., & Chen, Z. (2008) · Blood · doi:10.1182/blood-2007-07-102798 · Cited by 1,283 · see citing works
Persistent oxidative stress in cancer
Toyokuni, S., Okamoto, K., Yodoi, J., & Hiai, H. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01368-b · Cited by 1,219 · see citing works
(2002) · PubMed · Cited by 1,190 · see citing works
The antioxidant function of the p53 tumor suppressor
Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works
Trachootham, D., Zhou, Y., Zhang, H., Demizu, Y., Chen, Z., Pelicano, H., Chiao, P. J., Achanta, G., Arlinghaus, R. B., Liu, J., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.009 · Cited by 1,080 · see citing works
Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075 · see citing works
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060 · see citing works
Reactive Oxygen Species: A Breath of Life or Death?
Fruehauf, J. P., & Meyskens, F. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2082 · Cited by 908 · see citing works
Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804226105 · Cited by 854 · see citing works
Superoxide dismutase as a target for the selective killing of cancer cells
Huang, P., Li, F., Oldham, E. A., Keating, M. J., & Plunkett, W. K. (2000) · Nature · doi:10.1038/35030140 · Cited by 842 · see citing works
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
Wang, X.-J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G. T., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn095 · Cited by 839 · see citing works
Self-citationXu, R., Pelicano, H., Zhou, Y. N., Carew, J. S., Feng, L., Bhalla, K. N., Keating, M. J., & Huang, P. (2005) · Cancer Research · doi:10.1158/0008-5472.613.65.2 · Cited by 835 · see citing works
Mathupala, S. P., Ko, Y. H., & Pedersen, P. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209603 · Cited by 766 · see citing works
Azad, M. B., Chen, Y., & Gibson, S. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2270 · Cited by 761 · see citing works
Holmquist-Mengelbier, L., Fredlund, E., Löfstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, Å., Gradin, K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.026 · Cited by 735 · see citing works
Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy
Nyman, E., & Hynninen, P. H. (2003) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2003.10.002 · Cited by 714 · see citing works
Griffith, O. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33504-x · Cited by 701 · see citing works
Chen, D., Cui, Q. C., Yang, H., & Dou, Q. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2126 · Cited by 678 · see citing works
Chen, Q., Espey, M. G., Sun, A. Y., Lee, J.-H., Krishna, M. C., Shacter, E., Choyke, P. L., Pooput, C., Kirk, K. L., Buettner, G. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702854104 · Cited by 676 · see citing works
Bleomycins: towards better therapeutics
Chen, J., & Stubbe, J. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1547 · Cited by 668 · see citing works
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
Michelakis, E. D., Webster, L., & Mackey, J. R. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604554 · Cited by 657 · see citing works
LAU, A., VILLENEUVE, N., Sun, Z., Wong, P. K., & Zhang, D. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.09.003 · Cited by 645 · see citing works
Tatum, J. L. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000601002324 · Cited by 620 · see citing works
Mitochondrial tumour suppressors: a genetic and biochemical update
Gottlieb, E., & Tomlinson, I. P. M. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1737 · Cited by 617 · see citing works
Redox regulation of PI 3‐kinase signalling via inactivation of PTEN
Leslie, N. R., Bennett, D., Lindsay, Y. E., Stewart, H., Gray, A., & Downes, C. P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg513 · Cited by 614 · see citing works
Bioenergetics and the formation of mitochondrial reactive oxygen species
Ádám‐Vizi, V., & Chinopoulos, C. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.10.005 · Cited by 613 · see citing works
Multi-targeted prevention of cancer by sulforaphane
Clarke, J., Dashwood, R. H., & Ho, E. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.018 · Cited by 567 · see citing works
Lillig, C. H., Berndt, C., & Holmgren, A. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.06.003 · Cited by 563 · see citing works
Jing, Y., Dai, J., Chalmers-Redman, R. M. E., Tatton, W. G., & Waxman, S. (1999) · Blood · doi:10.1182/blood.v94.6.2102 · Cited by 542 · see citing works
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
Lu, J., Chew, E.-H., & Holmgren, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701549104 · Cited by 526 · see citing works
Thioredoxin Reductase Is Irreversibly Modified by Curcumin
Fang, J., Lu, J., & Holmgren, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414645200 · Cited by 521 · see citing works
Kwok, B. H. B., Koh, B. D., Ndubuisi, M. I., Elofsson, M., & Crews, C. M. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00049-7 · Cited by 516 · see citing works
Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling
Clarke, R., Liu, M. C., Bouker, K., Gu, Z.-P., Lee, R., Zhu, Y., Skaar, T., Gomez, B. P., O'Brien, K. A., Wang, Y., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206937 · Cited by 514 · see citing works
Whitnall, M., Howard, J., Ponka, P., & Richardson, D. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604979103 · Cited by 510 · see citing works
Controlling Tumor Growth by Modulating Endogenous Production of Reactive Oxygen Species
Laurent, A., Nicco, C., Chéreau, C., Goulvestre, C., Alexandre, J., Alvès, A., Lévy, E., Goldwasser, F., Panis, Y. H., Soubrane, O., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.948.65.3 · Cited by 506 · see citing works
Inhibition of Mitochondrial Respiration
Pelicano, H., Feng, L., Zhou, Y., Carew, J. S., Hileman, E. O., Plunkett, W., Keating, M. J., & Huang, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301546200 · Cited by 495 · see citing works
NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger
Siegel, D. M., Gustafson, D. L., Dehn, D. L., Han, J. Y., Boonchoong, P., Berliner, L. J., & Ross, D. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1238 · Cited by 455 · see citing works
Maschek, G., Savaraj, N., Priebe, W., Braunschweiger, P. G., Hamilton, K., Tidmarsh, G. F., Young, L. R. D., & Lampidis, T. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3294 · Cited by 452 · see citing works
A Specific and Sensitive Assay for Disulfides
Zahler, W. L., & Cleland, W. W. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81724-6 · Cited by 446 · see citing works
Chen, Y., McMillan‐Ward, E., Kong, J., Israels, S. J., & Gibson, S. B. (2007) · Journal of Cell Science · doi:10.1242/jcs.011163 · Cited by 444 · see citing works
Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
Liu, Y. (2006) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500879 · Cited by 433 · see citing works
Aykin‐Burns, N., Ahmad, I. M., Zhu, Y., Oberley, L. W., & Spitz, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20081258 · Cited by 433 · see citing works
Fribley, A. M., Zeng, Q., & Wang, C.-Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9695-9704.2004 · Cited by 424 · see citing works
Marzano, C., Gandin, V., Folda, A., Scutari, G., Bindoli, A., & Rigobello, M. P. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.021 · Cited by 415 · see citing works
Matrix Metalloproteinase-2 Contributes to Cancer Cell Migration on Collagen
Xu, X., Wang, Y., Chen, Z., Sternlicht, M. D., Hidalgo, M. M., & Steffensen, B. (2005) · Cancer Research · doi:10.1158/0008-5472.130.65.1 · Cited by 414 · see citing works
Wondrak, G. T., Jacobson, M. K., & Jacobson, E. L. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b504573h · Cited by 411 · see citing works
Self-citationCysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones
García‐Piñeres, A., Castro, V., MORA, G. A., Schmidt, T. J., Strunck, E., Pahl, H. L., & Merfort, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101985200 · Cited by 408 · see citing works
Hong, F., Freeman, M. L., & Liebler, D. C. (2005) · Chemical Research in Toxicology · doi:10.1021/tx0502138 · Cited by 404 · see citing works
Guzmán, M. L., Rossi, R. M., Neelakantan, S., Li, X., Corbett, C. A., Hassane, D. C., Becker, M. W., Bennett, J. M., Sullivan, E., Lachowicz, J. L., et al. (2007) · Blood · doi:10.1182/blood-2007-05-090621 · Cited by 404 · see citing works
Yancik, R. (2005) · The Cancer Journal · doi:10.1097/00130404-200511000-00002 · Cited by 392 · see citing works
López‐Lázaro, M. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700238 · Cited by 389 · see citing works
Collateral Damage in Cancer Chemotherapy: Oxidative Stress in Nontargeted Tissues
Chen, Y., Jungsuwadee, P., Vore, M. E., Butterfield, D. A., & Clair, D. K. S. (2007) · Molecular Interventions · doi:10.1124/mi.7.3.6 · Cited by 388 · see citing works
Alexandre, J., Hu, Y., Lu, W., Pelicano, H., & Huang, P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3914 · Cited by 380 · see citing works
Bush, J., Cheung, K. J., & Li, G. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5381 · Cited by 379 · see citing works
Jacob, C. (2006) · Natural Product Reports · doi:10.1039/b609523m · Cited by 373 · see citing works
Singh, A., Boldin‐Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J. B., Blackford, A. L., Goodman, S. N., Bunz, F., Watson, W. H., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1401 · Cited by 371 · see citing works
Reactive Oxygen Species Produced by NAD(P)H Oxidase Inhibit Apoptosis in Pancreatic Cancer Cells
Vaquero, E. C., Edderkaoui, M., Pandol, S. J., Gukovsky, I., & Gukovskaya, A. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400078200 · Cited by 366 · see citing works
Glutathione peroxidases and redox-regulated transcription factors
Brigelius‐Flohé, R. (2006) · Biological Chemistry · doi:10.1515/bc.2006.166 · Cited by 361 · see citing works
Tumor Hypoxia in Cancer Therapy
Brown, J. M. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)35015-5 · Cited by 359 · see citing works
Elesclomol induces cancer cell apoptosis through oxidative stress
Kirshner, J. R., He, S., Balasubramanyam, V., Kepros, J., Yang, C., Zhang, M., Du, Z., Barsoum, J., & Bertin, J. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0298 · Cited by 356 · see citing works
Cellular Thiols and Reactive Oxygen Species in Drug-Induced Apoptosis
Davis, W., Ronai, Z. A., & Tew, K. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29655-5 · Cited by 352 · see citing works
Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
Ko, Y. H., Smith, B. L., Wang, Y., Pomper, M. G., Rini, D. A., Torbenson, M. S., Hullihen, J. M., & Pedersen, P. L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.047 · Cited by 352 · see citing works
(2002) · PubMed · Cited by 349 · see citing works
Why is cancer drug discovery so difficult?
Kamb, A., Wee, S., & Lengauer, C. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2155 · Cited by 339 · see citing works
Disulfiram Facilitates Intracellular Cu Uptake and Induces Apoptosis in Human Melanoma Cells
Cen, D., Brayton, D. F., Shahandeh, B., Meyskens, F. L., & Farmer, P. J. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049568z · Cited by 336 · see citing works
Spitz, D. R., Sim, J. E., Ridnour, L. A., Galoforo, S., & Lee, Y. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06199.x · Cited by 331 · see citing works
Alexandre, J., Batteux, F., Nicco, C., Chéreau, C., Laurent, A., Guillevin, L., Weill, B., & Goldwasser, F. (2006) · International Journal of Cancer · doi:10.1002/ijc.21685 · Cited by 328 · see citing works
The BCR/ABL Tyrosine Kinase Induces Production of Reactive Oxygen Species in Hematopoietic Cells
Sattler, M., Verma, S., Shrikhande, G., Byrne, C. H., Pride, Y. B., Winkler, T., Greenfield, E. A., Salgia, R., & Griffin, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002094200 · Cited by 323 · see citing works
Koh, M. Y., Spivak-Kroizman, T., Venturini, S., Welsh, S., Williams, R. R., Kirkpatrick, D. L., & Powis, G. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0463 · Cited by 309 · see citing works
Glycolysis in cancer: A potential target for therapy
Gatenby, R. A., & Gillies, R. J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.021 · Cited by 305 · see citing works
Tsou, H., Overbeek, E., Hallett, W. A., Reich, M. F., Floyd, M. B., Johnson, B. D., Michalak, R. S., Nilakantan, R., Discafani, C. M., Golas, J., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040159c · Cited by 302 · see citing works
The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation
Mitsushita, J., Lambeth, J., & Kamata, T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3909 · Cited by 302 · see citing works
Dong, L.-F., Low, P., Dyason, J. C., Wang, X.-F., Procházka, L., Witting, P. K., Freeman, R., Swettenham, E., Vališ, K., Liu, J., et al. (2008) · Oncogene · doi:10.1038/onc.2008.69 · Cited by 297 · see citing works
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
Koptyra, M., Falinski, R., Nowicki, M. O., Stokłosa, T., Majsterek, I., Nieborowska-Skorska, M., Błasiak, J., & Skórski, T. (2006) · Blood · doi:10.1182/blood-2005-07-2815 · Cited by 297 · see citing works
Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity
Ramanathan, B., Jan, K.-Y., Chen, C., Hour, T., Yu, H., & Pu, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1162 · Cited by 287 · see citing works
Stoltzman, C. A., Peterson, C. W., Breen, K. T., Muoio, D. M., Billin, A. N., & Ayer, D. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712199105 · Cited by 283 · see citing works
Welsh, S. J., Williams, R. R., Kirkpatrick, L., Paine-Murrieta, G. D., & Powis, G. (2004) · PubMed · Cited by 280 · see citing works
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression
Fang, J. S., Gillies, R. D., & Gatenby, R. A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.011 · Cited by 279 · see citing works
Induction of Apoptosis by Curcumin and Its Implications for Cancer Therapy
Karunagaran, D., Rashmi, R., & Kumar, T. (2005) · Current Cancer Drug Targets · doi:10.2174/1568009053202081 · Cited by 278 · see citing works
Mechanisms of therapy-related carcinogenesis
Allan, J. M., & Travis, L. B. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1749 · Cited by 277 · see citing works
Synthetic peroxides as antimalarials
Tang, Y., Dong, Y., & Vennerstrom, J. L. (2004) · Medicinal Research Reviews · doi:10.1002/med.10066 · Cited by 277 · see citing works
Doctrow, S. R., Huffman, K. D., Marcus, C. B., Tocco, G., Malfroy, E., Adinolfi, C. A., Kruk, H., Baker, K. L., Lazarowych, N. J., Mascarenhas, J., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020207y · Cited by 275 · see citing works
Ascorbic acid enhances arsenic trioxide–induced cytotoxicity in multiple myeloma cells
Grad, J. M., Bahlis, N. J., Reis, I., Oshiro, M. M., Dalton, W. S., & Boise, L. (2001) · Blood · doi:10.1182/blood.v98.3.805 · Cited by 271 · see citing works
Wissner, A., Overbeek, E., Reich, M. F., Floyd, M. B., Johnson, B. D., Mamuya, N. N., Rosfjord, E. C., Discafani, C. M., Davis, R. E., Shi, X., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020241c · Cited by 270 · see citing works
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
Govindarajan, B., Sligh, J. E., Vincent, B. J., Li, M., Canter, J. A., Nickoloff, B. J., Rodenburg, R. J., Smeitink, J. A. M., Oberley, L. W., Zhang, Y., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30102 · Cited by 270 · see citing works
Efferth, T. (2007) · Planta Medica · doi:10.1055/s-2007-967138 · Cited by 269 · see citing works
Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs
Safe, S. H., Papineni, S., & Chintharlapalli, S. R. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.021 · Cited by 269 · see citing works
Catalase and glutathione peroxidase mimics
Day, B. J. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.029 · Cited by 269 · see citing works
Roche, T. E., & Hiromasa, Y. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6380-z · Cited by 265 · see citing works
Thioredoxin signaling as a target for cancer therapy
Powis, G., & Kirkpatrick, D. L. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.04.003 · Cited by 265 · see citing works
Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells
Efferth, T. (2006) · Current Drug Targets · doi:10.2174/138945006776359412 · Cited by 263 · see citing works
Powolny, A. A., & Singh, S. V. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.027 · Cited by 263 · see citing works
Chemistry and biology of natural and designed enediynes.
Nicolaou, K. C., Smith, A. L., & Yue, E. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.5881 · Cited by 258 · see citing works
Juarez, J. C., Manuia, M., Burnett, M. E., Betancourt, O., Boivin, B., Shaw, D. E., Tonks, N. K., Mazar, A. P., & Doñate, F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709451105 · Cited by 255 · see citing works
Ishii, T., Yasuda, K., Akatsuka, A., Hino, O., Hartman, P. S., & Ishii, N. (2005) · Cancer Research · doi:10.1158/0008-5472.203.65.1 · Cited by 253 · see citing works
(2003) · PubMed · Cited by 250 · see citing works
NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics
Ross, D., & Siegel, D. M. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)82008-1 · Cited by 247 · see citing works
Mitochondrial O2⋅¯ and H2O2 Mediate Glucose Deprivation-induced Stress in Human Cancer Cells
Ahmad, I. M., Aykin‐Burns, N., Sim, J. E., Walsh, S. A., Higashikubo, R., Buettner, G. R., Venkataraman, S., Mackey, M. A., Flanagan, S. W., Oberley, L. W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411662200 · Cited by 246 · see citing works
Kurtoğlu, M., Gao, N., Shang, J., Maher, J. C., Lehrman, M. A., Wangpaichitr, M., Savaraj, N., Lane, A. N., & Lampidis, T. J. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0310 · Cited by 241 · see citing works
Isolation of a small molecule inhibitor of DNA base excision repair
Madhusudan, S., Smart, F., Shrimpton, P. J., Parsons, J. L., Gardiner, L., Houlbrook, S., Talbot, D. C., Hammonds, T. R., Freemont, P. S., Sternberg, M. J. E., et al. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki781 · Cited by 239 · see citing works
Simons, A. L., Ahmad, I. M., Mattson, D., Dornfeld, K. J., & Spitz, D. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3717 · Cited by 238 · see citing works
Hosono, T., Hosono‐Fukao, T., Ogihara, J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507127200 · Cited by 237 · see citing works
Siwak, D. R., Shishodia, S., Aggarwal, B. B., & Kurzrock, R. (2005) · Cancer · doi:10.1002/cncr.21216 · Cited by 235 · see citing works
Shankar, S., & Srivastava, R. K. (2007) · International Journal of Oncology · doi:10.3892/ijo.30.4.905 · Cited by 232 · see citing works
Dell’Eva, R., Pfeffer, U., Venè, R., Anfosso, L., Forlani, A., Albini, A., & Efferth, T. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.08.021 · Cited by 230 · see citing works
Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling
Kallifatidis, G., Rausch, V., Baumann, B., Apel, A., Beckermann, B. M., Groth, A., Mattern, J., Li, Z., Kolb, A., Moldenhauer, G., et al. (2008) · Gut · doi:10.1136/gut.2008.149039 · Cited by 229 · see citing works
Redox Regulation in Human Melanocytes and Melanoma
Meyskens, F. L., Farmer, P. J., & Fruehauf, J. P. (2001) · Pigment Cell Research · doi:10.1034/j.1600-0749.2001.140303.x · Cited by 225 · see citing works
Kato, M., Li, J., Chuang, J. L., et al. (2007) · Structure · doi:10.1016/j.str.2007.07.001 · Cited by 222 · see citing works
Fang, J. Q., Sawa, T., Akaike, T., Akuta, T., Sahoo, S. K., Greish, K. F., Hamada, A., & Maeda, H. (2003) · PubMed · Cited by 221 · see citing works
Artemisinin induces apoptosis in human cancer cells.
Singh, N. P., & Lai, H. C. (2004) · PubMed · Cited by 220 · see citing works
Mao, X., Yu, C. R., Li, W. H., & Li, W. (2008) · Cell Research · doi:10.1038/cr.2008.86 · Cited by 218 · see citing works
Berndtsson, M., Hägg, M., Panaretakis, T., Havelka, A. M., Shoshan, M. C., & Linder, S. T. (2006) · International Journal of Cancer · doi:10.1002/ijc.22132 · Cited by 216 · see citing works
Nonn, L., Berggren, M. M., & Powis, G. (2003) · PubMed · Cited by 216 · see citing works
Cabello, C. M., Bair, W. B., Lamore, S. D., Ley, S., Bause, A. S., Azimian, S., & Wondrak, G. T. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.10.025 · Cited by 215 · see citing works
Self-citationThe iron metabolism of neoplastic cells: Alterations that facilitate proliferation?
Kwok, J. C., & Richardson, D. R. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00213-x · Cited by 215 · see citing works
Filomeni, G., Aquilano, K., Rotilio, G., & Ciriolo, M. R. (2003) · PubMed · Cited by 211 · see citing works
Molecular Mechanisms of Resistance to Therapies Targeting the Epidermal Growth Factor Receptor
Camp, E. R., Summy, J. M., Bauer, T. W., Liu, W., Gallick, G. E., & Ellis, L. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.397.11.1 · Cited by 210 · see citing works
Adams, B. K., Cai, J., Armstrong, J., et al. (2005) · Anti-Cancer Drugs · doi:10.1097/00001813-200503000-00005 · Cited by 202 · see citing works
Zheng, Y., Shi, Y., Tian, C., Jiang, C., Jin, H., Chen, J., Almasan, A., Tang, H., & Chen, Q. (2003) · Oncogene · doi:10.1038/sj.onc.1207205 · Cited by 202 · see citing works
Gupta, A. K., Rosenberger, S. F., & Bowden, G. T. (1999) · Carcinogenesis · doi:10.1093/carcin/20.11.2063 · Cited by 202 · see citing works
Marty, M. E., Espié, M., Llombart‐Cussac, A., Monnier, A., Rapoport, B. L., & Stahalova, V. (2006) · Annals of Oncology · doi:10.1093/annonc/mdj134 · Cited by 201 · see citing works
Covalent Binding to Tubulin by Isothiocyanates
Mi, L., Xiao, Z., Hood, B. L., Dakshanamurthy, S., Wang, X., Govind, S., Conrads, T. P., Veenstra, T. D., & Chung, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802330200 · Cited by 200 · see citing works
Isham, C. R., Tibodeau, J. D., Jin, W., Xu, R., Timm, M., & Bible, K. C. (2006) · Blood · doi:10.1182/blood-2006-07-027326 · Cited by 200 · see citing works
Alexandre, J., Nicco, C., Chéreau, C., Laurent, A., Weill, B. J., Goldwasser, F., & Batteux, F. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj049 · Cited by 200 · see citing works
Artesunate Derived from Traditional Chinese Medicine Induces DNA Damage and Repair
Li, P. C. H., Lam, E., Roos, W. P., Zdzienicka, M. Z., Kaina, B., & Efferth, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2970 · Cited by 199 · see citing works
Protein Disulfide Isomerase Expression Is Related to the Invasive Properties of Malignant Glioma
Goplen, D., Wang, J., Enger, P. Ø., Tysnes, B. B., Terzis, A. J. A., Lærum, O. D., & Bjerkvig, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4589 · Cited by 193 · see citing works
RAÏS, B., Comin, B., Puigjaner, J., Brandes, J. L., Creppy, E. E., Saboureau, D., Ennamany, R., Lee, W. P., Boros, L. G., & Cascante, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00924-2 · Cited by 192 · see citing works
Meuillet, E. J., Mahadevan, D., Berggren, M. I., Coon, A., & Powis, G. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.04.020 · Cited by 192 · see citing works
The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis
Frohlich, D. A., McCabe, M. T., Arnold, R. S., & Day, M. L. (2008) · Oncogene · doi:10.1038/onc.2008.79 · Cited by 192 · see citing works
Overexpression of manganese or copper–zinc superoxide dismutase inhibits breast cancer growth
Weydert, C. J. D., Waugh, T. A., Ritchie, J. M., Iyer, K. S., Smith, J. L., Li, L., Spitz, D. R., & Oberley, L. W. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.015 · Cited by 191 · see citing works
Nakase, I., Lai, H., Singh, N. P., & Sasaki, T. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.09.003 · Cited by 190 · see citing works
Bahlis, N. J., Grad, J. M., Jordan-McMurry, I., Neil, J., Reis, I., Kharfan‐Dabaja, M. A., Eckman, J. R., Goodman, M. S., Fernandez, H. F., Boise, L., et al. (2002) · PubMed · Cited by 190 · see citing works
Redox Signaling in Cancer Biology
Gius, D. R., & Spitz, D. R. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1249 · Cited by 189 · see citing works
DT-diaphorase: a target for new anticancer drugs
Danson, S. J., Ward, T. H., Butler, J., & Ranson, M. (2004) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2004.01.002 · Cited by 188 · see citing works
Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma
Solit, D. B., Osman, I., Polsky, D., Panageas, K. S., DAUD, A. I., Goydos, J. S., Teitcher, J. B., Wolchok, J. D., Germino, F. J., Krown, S. E., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1002 · Cited by 188 · see citing works
Yamaura, M., Mitsushita, J., Furuta, S., Kiniwa, Y., Ashida, A., Goto, Y., Shang, W. H., Kubodera, M., Kato, M., Takata, M., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3745 · Cited by 187 · see citing works
Maeda, H., Hori, S., Ohizumi, H., Segawa, T., Kakehi, Y., Ogawa, O., & Kakizuka, A. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401389 · Cited by 183 · see citing works
Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts
Blander, G., de Oliveira, R. M., Conboy, C. M., Haigis, M., & Guarente, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307146200 · Cited by 183 · see citing works
Doi, K., Akaike, T., Fujii, S., Tanaka, S., Ikebe, N., Beppu, T., Shibahara, S., Ogawa, M., & Maeda, H. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690624 · Cited by 182 · see citing works
The Redox Regulation of Thiol Dependent Signaling Pathways in Cancer
Giles, G. I. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206779010549 · Cited by 182 · see citing works
Kim, H., Kim, E. H., Eom, Y. W., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1568 · Cited by 181 · see citing works
The Development of HKI‐272 and Related Compounds for the Treatment of Cancer
Wissner, A., & Mansour, T. S. (2008) · Archiv der Pharmazie · doi:10.1002/ardp.200800009 · Cited by 179 · see citing works
Asher, G., Dym, O., Tsvetkov, P., Adler, J., & Shaul, Y. (2006) · Biochemistry · doi:10.1021/bi0600087 · Cited by 177 · see citing works
Artesunate in the treatment of metastatic uveal melanoma - first experiences
Berger, T. G., Dieckmann, D., Efferth, T., Schultz, E. S., Funk, J.-O., Baur, A. S., & Schuler, G. (2005) · Oncology Reports · doi:10.3892/or.14.6.1599 · Cited by 176 · see citing works
Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit
Jeon, K., Byun, M.-S., & Jue, D. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.9 · Cited by 173 · see citing works
Cdc25 Phosphatases: Structure, Specificity, and Mechanism
Rudolph, J. (2007) · Biochemistry · doi:10.1021/bi700026j · Cited by 173 · see citing works
Thioredoxin reductase as a novel molecular target for cancer therapy
Nguyen, P., Awwad, R. T., Smart, D. D., Spitz, D. R., & Gius, D. R. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.04.028 · Cited by 173 · see citing works
Brar, S. S., Grigg, C., Wilson, K. S., Holder, W. D., Dréau, D., Austin, C. E., Foster, M., Ghio, A. J., Whorton, A. R., Stowell, G. W., et al. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1049.3.9 · Cited by 172 · see citing works
Sannella, A. R., Casini, A., Gabbiani, C., Luigi Messori, A., Bilia, A. R., Vincieri, F., Majori, G., & Severini, C. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.028 · Cited by 172 · see citing works
Xiao, D., Powolny, A. A., & Singh, S. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802529200 · Cited by 170 · see citing works
Lai, H. C., & Singh, N. P. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.01.019 · Cited by 170 · see citing works
Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy
Efferth, T. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2005.04.003 · Cited by 169 · see citing works
Luo, M., Delaplane, S., Jiang, A., Reed, A. M., He, Y., Fishel, M. L., Nyland, R. L., Borch, R. F., Qiao, X., Georgiadis, M. M., et al. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2120 · Cited by 167 · see citing works
A catabolic block does not sufficiently explain how 2-deoxy- d -glucose inhibits cell growth
Ralser, M., Wamelink, M. M. C., Struys, E. A., Joppich, C., Krobitsch, S., Jakobs, C., & Lehrach, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803090105 · Cited by 166 · see citing works
Ruscoe, J. E., Rosario, L. A., Wang, T., Gaté, L., Arifoglu, P., Wolf, C. R., Henderson, C. J., Ronai, Z. A., & Tew, K. D. (2001) · PubMed · Cited by 165 · see citing works
Roy, A., Ganguly, A., Dasgupta, S. B., Das, B. B., Pal, C., Jaisankar, P., & Majumder, H. K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050161 · Cited by 164 · see citing works
Hashemy, S. I., Ungerstedt, J. S., Avval, F. Z., & Holmgren, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511373200 · Cited by 164 · see citing works
Mehta, M. P., Shapiro, W. R., Phan, S. C., Gervais, R., Carrié, C., Chabot, P., Patchell, R. A., Glantz, M., Recht, L. D., Langer, C. J., et al. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.05.068 · Cited by 163 · see citing works
Motexafin gadolinium: A novel redox active drug for cancer therapy
Magda, D. J., & Miller, R. A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.09.002 · Cited by 163 · see citing works
Willoughby, J. A., Sundar, S. N., Cheung, M., Tin, A. S., Modiano, J. F., & Firestone, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804491200 · Cited by 162 · see citing works
Gallegos, A. C., Gasdaska, J. R., Taylor, C. W., Paine-Murrieta, G. D., Goodman, D., Gasdaska, P. Y., Berggren, M. I., Briehl, M. M., & Powis, G. (1996) · PubMed · Cited by 161 · see citing works
Juarez, J. C., Betancourt, O., Pirie-Shepherd, S. R., Guan, X., Price, M. L., Shaw, D. E., Mazar, A. P., & Doñate, F. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0171 · Cited by 160 · see citing works
Kakolyris, S., Giatromanolaki, A., Koukourakis, M. I., et al. (2001) · PubMed · Cited by 160 · see citing works
Ma, B. B. Y., Goh, B. C., Tan, E. H., Lam, K. C., Soo, R. A., Leong, S. S., Wang, L. Z., Mo, F. K. F., Chan, A. T. �., Zee, B. C.-Y., et al. (2007) · Investigational New Drugs · doi:10.1007/s10637-007-9085-0 · Cited by 158 · see citing works
Fang, J. Q., Sawa, T., Akaike, T., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11644 · Cited by 156 · see citing works
Antosiewicz, J., Herman-Antosiewicz, A., Marynowski, S. W., & Singh, S. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0356 · Cited by 156 · see citing works
Sweeney, C. J., Mehrotra, S., Sadaria, M. R., Kumar, S., Shortle, N. H., Roman, Y., Sheridan, C., Campbell, R. A., Murry, D. J., Badve, S., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0030 · Cited by 156 · see citing works
Dominici, S., Valentini, M., Maellaro, E., Bello, B. D., Paolicchi, A., Lorenzini, E., Tongiani, R., Comporti, M., & Alfonso Pompella, C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00111-2 · Cited by 155 · see citing works
Rao, V. A., Klein, S. R., Agama, K., Toyoda, E., Adachi, N., Pommier, Y. G., & Shacter, E. B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1437 · Cited by 155 · see citing works
Dihydroartemisinin Is Cytotoxic to Papillomavirus-Expressing Epithelial Cells In vitro and In vivo
Disbrow, G. L., Baege, A. C., Kierpiec, K. A., Yuan, H., Centeno, J. A., Thibodeaux, C. A., Hartmann, D., & Schlegel, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1216 · Cited by 154 · see citing works
Tumor Protein 53–Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function
Cano, C. E., Gommeaux, J., Pietri, S., Culcasi, M., Garcia, S., Seux, M., Barelier, S., Vasseur, S., Spoto, R. P., Pébusque, M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2320 · Cited by 153 · see citing works
Das, A., Banik, N. L., & Ray, S. K. (2007) · Cancer · doi:10.1002/cncr.22888 · Cited by 152 · see citing works
Krishna, M. C., DeGraff, W., Hankovszky, O. H., Sár, C. P., Kálai, T., Jekő, J., Russo, A., Mitchell, J. B., & Hideg, K. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm9802160 · Cited by 152 · see citing works
Kuo, P., Chen, C., & Hsu, Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1089 · Cited by 152 · see citing works
Hicks, K. O., Pruijn, F. B., Secomb, T. W., Hay, M. P., Hsu, R., Brown, J. M., Denny, W. A., Dewhirst, M. W., & Wilson, W. R. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj306 · Cited by 152 · see citing works
Cullen, J. J., Hinkhouse, M. M., Grady, M., et al. (2003) · PubMed · Cited by 149 · see citing works
The Redox Regulation of PI 3-Kinase–Dependent Signaling
Leslie, N. R. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1765 · Cited by 148 · see citing works
Gong, Y., Sohn, H., Xue, L., Firestone, G. L., & Bjeldanes, L. F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4162 · Cited by 148 · see citing works
Kopnin, P., Agapova, L. S., Kopnin, B. P., & Chumakov, P. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2466 · Cited by 146 · see citing works
Oxidation of Zinc Finger Transcription Factors: Physiological Consequences
Webster, K. A., Prentice, H. M., & Bishopric, N. (2001) · Antioxidants and Redox Signaling · doi:10.1089/15230860152542916 · Cited by 145 · see citing works
Kalinowski, D. S., & Richardson, D. R. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700039c · Cited by 145 · see citing works
Wardman, P. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372959 · Cited by 145 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sies, H., Berndt, C., & Jones, D. P. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045037 · Cited by 3,520 · see citing works
NRF2 and the Hallmarks of Cancer
Rojo de la Vega, M., Chapman, E., & Zhang, D. D. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.022 · Cited by 1,672 · see citing works
Role of Glutathione in Cancer Progression and Chemoresistance
Traverso, N., Ricciarelli, R., Nitti, M., Marengo, B., Furfaro, A. L., Pronzato, M. A., Marinari, U. M., & Domenicotti, C. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/972913 · Cited by 1,208 · see citing works
Targeting cancer vulnerabilities with high-dose vitamin C
Ngo, B., Van Riper, J. M., Cantley, L. C., & Yun, J. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0135-7 · Cited by 423 · see citing works
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works
On the history of oxidative stress: Concept and some aspects of current development
Sies, H. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.01.002 · Cited by 285 · see citing works
Thiol regulation by Mn porphyrins, commonly known as SOD mimics
Batinic-Haberle, I., & Tome, M. E. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101139 · Cited by 88 · see citing works
Ma, J., Lim, C., Sacher, J. R., Van Houten, B., Qian, W., & Wipf, P. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.06.073 · Cited by 27 · see citing works
Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works
“…proposed by previous scholars, these strategies effectively integrate formulation, dosage and Pds into a coherent translational framework (166,195,197). deeper investigations into signaling pathways, including the NF‑ κ B, Nrf2 and AMPK pathways, will further clarify the underlying mechanisms of…”
- Authors
- Wondrak, G. T.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Wondrak, Georg T.
- ORCID
- Wondrak, Georg T.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2009-12
- Volume
- 11
- Issue
- 12
- Pages
- 3013-3069
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- PMC
- PMC2824519
- OpenAlex
- W2000718634
- Cited by
- 462
- References
- 406
- Citations by year
- 2026: 7 · 2025: 24 · 2024: 16 · 2023: 18 · 2022: 18 · 2021: 23 · 2020: 25 · 2019: 29 · 2018: 26 · 2017: 35 · 2016: 44 · 2015: 42 · 2014: 40 · 2013: 33 · 2012: 34
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Arizona Cancer Center (CA023074)
- Servier
- National Institutes of Health (CA023074, ES 06694)
- National Cancer Institute (R01CA122484, CA-023074, P30CA023074)
- National Institute of Environmental Health Sciences (ES 06694, P30ES006694)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- reactive oxygen species, redox dysregulation, cancer cell vulnerability, oncogene function, tumor suppressor, chemoresistance, synthetic lethality, redox signaling, drug discovery, clinical trials
- MeSH terms
- Antineoplastic Agents, Humans, Neoplasms, Oxidation-Reduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review