The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
NOX Enzymes in the Central Nervous System: From Signaling to Disease
Open accessAbstract
Oxidative stress has been implicated in the pathogenesis of neurologic and psychiatric diseases. The brain is particularly vulnerable to oxidative damage due to high oxygen consumption, low antioxidant defense, and an abundance of oxidation-sensitive lipids. Production of reactive oxygen species (ROS) by mitochondria is generally thought to be the main cause of oxidative stress. However, a role for ROS-generating NADPH oxidase NOX enzymes has recently emerged. Activation of the phagocyte NADPH oxidase NOX2 has been studied mainly in microglia, where it plays a role in inflammation, but may also contribute to neuronal death in pathologic conditions. However, NOX-dependent ROS production can be due to the expression of other NOX isoforms, which are detected not only in microglia, but also in astrocytes and neurons. The physiologic and pathophysiologic roles of such NOX enzymes are only partially understood. In this review, we summarize the present knowledge about NOX enzymes in the central nervous system and their involvement in neurologic and psychiatric diseases. Antioxid. Redox Signal. 11, 2481–2504.
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Cites
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
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Self-citationMicroglia-mediated neurotoxicity: uncovering the molecular mechanisms
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NOX enzymes and the biology of reactive oxygen
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Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
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Microglia Promote the Death of Developing Purkinje Cells
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Cited by
Oxidative Stress and the Central Nervous System
Salim, S. (2017) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,247
Reactive oxygen species: from health to disease
Brieger, K., Schiavone, S., Miller Jr., F. J., & Krause, K.-H. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13659 · Cited by 1,133
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“Induced expression of NOX1, NOX2, NOX3 and NOX4 has been reported in neurons in pathological conditions such as mechanical injury, mostly by immunofluorescent detection [64,65].”
BackgroundNox proteins in signal transduction
Brown, D. I., & Griendling, K. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.023 · Cited by 832
NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology
Vermot, A., Petit-Härtlein, I., Smith, S. M. E., & Fieschi, F. (2021) · Antioxidants · doi:10.3390/antiox10060890 · Cited by 766
Metadata
- Authors
- Sorce, S., & Krause, K.-H.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2009-10
- Volume
- 11
- Issue
- 10
- Pages
- 2481-2504
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2041365749
- Cited by
- 471
- References
- 41
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- green
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