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Cited by 136Sulfur Compounds in BiologyRedox biology and oxidative stressNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Hydrogen Sulfide and Oxygen Sensing in the Cardiovascular System

Olson, Kenneth R., Whitfield, Nathan L.·2010·Antioxidants & Redox Signaling
DOI 10.1089/ars.2009.2921
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Abstract

Vertebrate cardiorespiratory homeostasis is inextricably dependent upon specialized cells that provide feedback on oxygen status in the tissues, blood, and on occasion, environment. These "oxygen sensing" cells include chemoreceptors and oxygen-sensitive chromaffin cells that initiate cardiorespiratory reflexes, vascular smooth muscle cells that adjust perfusion to metabolism or ventilation, and other cells that condition themselves in response to episodic hypoxia. Identification of how these cells sense oxygen and transduce this into the appropriate physiological response has enormous clinical applicability, but despite intense research there is no consensus regarding the initial hypoxia-effector coupling mechanism. This review examines an alternative mechanism of oxygen sensing using oxidation of endogenously produced hydrogen sulfide (H(2)S) as the O(2)-sensitive couple. Support for this hypothesis includes the similarity of effects of hypoxia and H(2)S on a variety of tissues, augmentation of hypoxic responses by precursors of H(2)S production and their inhibition by inhibitors of H(2)S synthesis, and the rapid consumption of H(2)S by O(2) in the range of intracellular/mitochondrial Po(2). These studies also indicate that, under normoxic conditions, it is doubtful that free H(2)S has longer than a transient existence in tissue or extracellular fluid.

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Crossref · 10.1089/ars.2009.2921

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Research works printed but not linked: 2

  1. Madden JA, , Olson KR, , Roerig DL. Precursors of hydrogen sulfide synthesis augment acute hypoxic pulmonary vasoconstriction in the intact lung. Am J Respir Crit Care Med, 177:A252. 2008.
  2. Olson KR Whitfield NL Bearden SE St. Ledger J Nilson E Gao Y Madden JA. Hypoxic pulmonary vasodilation: A paradigm shift with a hydrogen sulfide mechanism. Am J Physiol Regul Integr Comp Physiol 2009(Epub: doi:10.1152/ajpregu.00576.2009) · DOI

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Metadata

Authors
Olson, K. R., & Whitfield, N. L.
Affiliations
  • Indiana University South Bend (US)
  • University of Notre Dame (US)
Corresponding author
Olson, Kenneth R.
ORCID
Olson, Kenneth R.
Venue
Antioxidants & Redox Signaling
Publisher
SAGE Publications
Published
2010-05
Volume
12
Issue
10
Pages
1219-1234
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
DOI
10.1089/ars.2009.2921
OpenAlex
W2076177365
Cited by
136
References
76
Citations by year
2025: 3 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 15 · 2013: 20 · 2012: 17
FWCI
8.90
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
hydrogen sulfide, oxygen sensing, hypoxia, chemoreceptors, vascular smooth muscle cells, hydrogen sulfide oxidation, mitochondrial oxygen consumption, redox signaling
MeSH terms
Air Pollutants, Animals, Blood Vessels, Cardiovascular System, Carotid Body, Chemoreceptor Cells, Homeostasis, Humans, Hydrogen Sulfide, Oxidation-Reduction, Oxygen, Signal Transduction, Cell Hypoxia, Ischemic Preconditioning, Myocardial, Chromaffin Cells

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