The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Roles of Hydrogen Sulfide in the Pathogenesis of Diabetes Mellitus and Its Complications
Open accessAbstract
SIGNIFICANCE: Diabetes and its complications represent a major socioeconomic problem. RECENT ADVANCES: Changes in the balance of hydrogen sulfide (H(2)S) play an important role in the pathogenesis of β-cell dysfunction that occurs in response to type 1 and type 2 diabetes. In addition, changes in H(2)S homeostasis also play a role in the pathogenesis of endothelial injury, which develop on the basis of chronically or intermittently elevated circulating glucose levels in diabetes. CRITICAL ISSUES: In the first part of this review, experimental evidence is summarized implicating H(2)S overproduction as a causative factor in the pathogenesis of β-cell death in diabetes. In the second part of our review, experimental evidence is presented supporting the role of H(2)S deficiency (as a result of increased H(2)S consumption by hyperglycemic cells) in the pathogenesis of diabetic endothelial dysfunction, diabetic nephropathy, and cardiomyopathy. FUTURE DIRECTIONS: In the final section of the review, future research directions and potential experimental therapeutic approaches around the pharmacological modulation of H(2)S homeostasis in diabetes are discussed.
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Cites
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Van Belle, T. L., Coppieters, K. T., & Von Herrath, M. G. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2010 · Cited by 1,022
Levitt, M. D., Abdel-Rehim, M. S., & Furne, J. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3525 · Cited by 177
Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction
Szabo, C. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00086.x · Cited by 165
Cited by
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Metadata
- Authors
- Szabo, C.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2012-07
- Volume
- 17
- Issue
- 1
- Pages
- 68-80
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2012081068
- Cited by
- 217
- References
- 5
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Szabo, C. (2012). Roles of Hydrogen Sulfide in the Pathogenesis of Diabetes Mellitus and Its Complications. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2011.4451
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