Cited by 177Sulfur Compounds in BiologyGarlic and Onion StudiesRedox biology and oxidative stress

Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue

Levitt, Michael D., Abdel-Rehim, Mohamed Saber, Furne, Julie·2011·Antioxidants & Redox Signaling

Abstract

Endogenously produced hydrogen sulfide is thought to function as an intracellular messenger. There is, however, little information on tissue concentrations of free hydrogen sulfide, the putative messenger form of this molecule, versus that of the bound (acid-labile) form. The present report describes the application of a novel technique to measure free and acid-labile hydrogen sulfide in mouse tissues. Very low free hydrogen sulfide concentrations (<0.050 μmol/kg) were observed in brain, liver, blood, heart, kidney, striated muscle, and esophagus. Aortic concentrations of free hydrogen sulfide were 20 to 100 times greater than that of the other tissues. Acid-labile hydrogen sulfide concentrations were multiple orders of magnitude greater than that of the free form in every tissue other than aorta. Previous reports of tissue hydrogen sulfide concentrations of 30 to >100 μmol/kg measured bound rather than free hydrogen sulfide, the observation that aorta contains anomalously high free hydrogen sulfide concentrations lends support for a vasodilator function for this molecule, and the very low free hydrogen sulfide concentrations in most tissues seemingly requires intermediation of a yet to be described receptor-like mechanism if this molecule is to serve as a gasotransmitter.

Integrity signals

Registry

Crossref · 10.1089/ars.2010.3525

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Sulfide concentrations in rodents are higher in tissues than in blood, and the highest concentrations are observed in the vasculature, rendering the aorta a relevant target for the interaction of nitrite with sulfide.

    “As with nitrite [78], sulfide concentrations in rodents are higher in tissues than in blood, and the highest concentrations are observed in the vasculature [79], rendering the aorta a relevant target for the interaction of nitrite with sulfide.”

    From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [79]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Levitt, M. D., Abdel-Rehim, M. S., & Furne, J.
Affiliations
  • University of Minnesota (US)
  • Veterans Health Administration (US)
Corresponding author
Levitt, Michael D.
Venue
Antioxidants & Redox Signaling
Published
2011-07-15
Volume
15
Issue
2
Pages
373-378
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
OpenAlex
W2058206341
Cited by
177
References
29
Citations by year
2026: 2 · 2025: 4 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 12 · 2012: 13
FWCI
5.74
Type
journal article
Language
en
Open access
closed
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
hydrogen sulfide, gasotransmitters, aorta, vasodilation, intracellular signaling, mouse tissues
MeSH terms
Animals, Aorta, Hydrogen Sulfide, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review