Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue
Abstract
Endogenously produced hydrogen sulfide is thought to function as an intracellular messenger. There is, however, little information on tissue concentrations of free hydrogen sulfide, the putative messenger form of this molecule, versus that of the bound (acid-labile) form. The present report describes the application of a novel technique to measure free and acid-labile hydrogen sulfide in mouse tissues. Very low free hydrogen sulfide concentrations (<0.050 μmol/kg) were observed in brain, liver, blood, heart, kidney, striated muscle, and esophagus. Aortic concentrations of free hydrogen sulfide were 20 to 100 times greater than that of the other tissues. Acid-labile hydrogen sulfide concentrations were multiple orders of magnitude greater than that of the free form in every tissue other than aorta. Previous reports of tissue hydrogen sulfide concentrations of 30 to >100 μmol/kg measured bound rather than free hydrogen sulfide, the observation that aorta contains anomalously high free hydrogen sulfide concentrations lends support for a vasodilator function for this molecule, and the very low free hydrogen sulfide concentrations in most tissues seemingly requires intermediation of a yet to be described receptor-like mechanism if this molecule is to serve as a gasotransmitter.
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Sulfide concentrations in rodents are higher in tissues than in blood, and the highest concentrations are observed in the vasculature, rendering the aorta a relevant target for the interaction of nitrite with sulfide.
“As with nitrite [78], sulfide concentrations in rodents are higher in tissues than in blood, and the highest concentrations are observed in the vasculature [79], rendering the aorta a relevant target for the interaction of nitrite with sulfide.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [79]
Cites
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310 · see citing works
The possible role of hydrogen sulfide as an endogenous neuromodulator
Abe, K., & Kimura, H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01066.1996 · Cited by 2,216 · see citing works
Stipanuk, M. H., & Beck, P. W. (1982) · Biochemical Journal · doi:10.1042/bj2060267 · Cited by 710 · see citing works
Furne, J. K., Saeed, A., & Levitt, M. D. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90566.2008 · Cited by 628 · see citing works
Singh, S., Padovani, D., Leslie, R. A., Chiku, T., & Banerjee, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.010868 · Cited by 615 · see citing works
A Source of Hydrogen Sulfide and a Mechanism of Its Release in the Brain
Ishigami, M., Hiraki-Kamon, K., Umemura, K., Ogasawara, Y., Ishii, K., & Kimura, H. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2132 · Cited by 478 · see citing works
Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
Nelson, M. E., Kuryatov, A., Choi, C. H., Zhou, Y., & Lindstrom, J. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.332 · Cited by 422 · see citing works
Dorman, D. C. (2002) · Toxicological Sciences · doi:10.1093/toxsci/65.1.18 · Cited by 362 · see citing works
Goodwin, L. R., Francom, D. M., Dieken, F. P., Taylor, J. D., Warenycia, M. W., Reiffenstein, R. J., & Dowling, G. (1989) · Journal of Analytical Toxicology · doi:10.1093/jat/13.2.105 · Cited by 323 · see citing works
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats
Wallace, J. L., Vong, L., McKnight, W., Dicay, M., & Martin, G. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.012 · Cited by 308 · see citing works
Tang, G., Wu, L., Liang, W., & Wang, R. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.017467 · Cited by 294 · see citing works
Hydrogen Sulfide Is a Mediator of Cerebral Ischemic Damage
Qu, K., Chen, C., Halliwell, B. B., Moore, P. K., & Wong, P. T. ‐. (2006) · Stroke · doi:10.1161/01.str.0000204184.34946.41 · Cited by 272 · see citing works
Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa
Levitt, M. D., Furne, J. K., Springfield, J. R., Suarez, F. L., & DeMaster, E. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7712 · Cited by 248 · see citing works
Furne, J. K., Springfield, J. R., Koenig, T. W., DeMaster, E. G., & Levitt, M. D. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00657-8 · Cited by 223 · see citing works
Hydrogen Sulfide Is a Novel Prosecretory Neuromodulator in the Guinea-Pig and Human Colon
Schicho, R., Krueger, D., Zeller, F., von Weyhern, C. W. H., Frieling, T., Kimura, H., Ishii, I., GIORGIO, R. D., Campi, B., & Schemann, M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.035 · Cited by 218 · see citing works
Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation
Bianca, R. D. D. V., Sorrentino, R., Maffia, P., Mirone, V. G., Imbimbo, C., Fusco, F., Palma, R. D., Ignarro, L. J., & Cirino, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807974105 · Cited by 199 · see citing works
Savage, J. C., & Gould, D. H. (1990) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)82537-2 · Cited by 198 · see citing works
Assay methods and biological roles of labile sulfur in animal tissues
UBUKA, T. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00623-2 · Cited by 165 · see citing works
Yang, G., Cao, K., Wu, L., & Wang, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408997200 · Cited by 159 · see citing works
Ogasawara, Y., Isoda, S., & TANABE, S. (1994) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.17.1535 · Cited by 158 · see citing works
The solubility of hydrogen sulphide in water from 0 to 90°C and pressures to 1 MPa
Carroll, J. J., & Mather, A. E. (1989) · Geochimica et Cosmochimica Acta · doi:10.1016/0016-7037(89)90053-7 · Cited by 136 · see citing works
Stipanuk, M. H., Londono, M. P., Lee, J.-I., Hu, M., & Yu, A. F. (2002) · Journal of Nutrition · doi:10.1093/jn/132.11.3369 · Cited by 135 · see citing works
Han, Y., Qin, J., Chang, X., Yang, Z., & Du, J. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-8848-z · Cited by 108 · see citing works
INHIBITION OF RESPIRATORY AND BIOENERGETIC MECHANISMS BY HYDROGEN SULFIDE IN MAMMALIAN BRAIN
Rot, R. A. N. S. H. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158773 · Cited by 75 · see citing works
High‐performance liquid chromatography detection of sulfide in tissues from sulfide‐treated mice
Mitchell, T. W., Savage, J. C., & Gould, D. H. (1993) · Journal of Applied Toxicology · doi:10.1002/jat.2550130605 · Cited by 61 · see citing works
The actions of hydrogen sulfide on dorsal raphe serotonergic neurons in vitro
Kombian, S. B., Reiffenstein, R. J., & Colmers, W. F. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.81 · Cited by 58 · see citing works
A sensitive gas chromatographic method for determination of protein-associated sulfur
Hannestad, U., Margheri, S., & Sörbo, B. H. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90659-3 · Cited by 52 · see citing works
Huang, S., CHOWDHURY, J. U., KOBAYASHI, K., & Tomita, T. (1993) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.43.229 · Cited by 17 · see citing works
Yamada, H., Otsuka, M., Fujimoto, K., Kawashima, K., & Yoshida, M. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb00175.x · Cited by 15 · see citing works
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Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935 · see citing works
Chemical Biology of H 2 S Signaling through Persulfidation
Filipović, M. R., Živanović, J., Álvarez, B., & Banerjee, R. V. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,039 · see citing works
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter
Wallace, J. L., & Wang, R. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4433 · Cited by 882 · see citing works
H2S signalling through protein sulfhydration and beyond
Paul, B. D., & Snyder, S. H. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3391 · Cited by 849 · see citing works
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabó, C., & Papapetropoulos, A. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 568 · see citing works
Hydrogen sulfide chemical biology: pathophysiological roles and detection
Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.002 · Cited by 480 · see citing works
Pedre, B., Barayeu, U., Ezeriņa, D., & Dick, T. P. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107916 · Cited by 476 · see citing works
Enzymology of H 2 S Biogenesis, Decay and Signaling
Kabil, Ö., & Banerjee, R. V. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5339 · Cited by 474 · see citing works
Cao, X., Ding, L., Xie, Z., Yang, Y., Whiteman, M., Moore, P. K., & Bian, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7058 · Cited by 409 · see citing works
Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras
Kashfi, K., & Olson, K. R. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.10.019 · Cited by 315 · see citing works
Hydrogen Sulfide Is a Signaling Molecule and a Cytoprotectant
Kimura, H., Shibuya, N., & Kimura, Y. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4345 · Cited by 291 · see citing works
Chemical aspects of hydrogen sulfide measurements in physiological samples
Nagy, P., Pálinkás, Z., Nagy, A., Budai, B., Tóth, I., & Vasas, A. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.037 · Cited by 285 · see citing works
Hydrogen Sulfide in the Mammalian Cardiovascular System
Liu, Y., Lu, M., Hu, L., Wong, P. T. ‐., Webb, G. D., & Bian, J. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4005 · Cited by 264 · see citing works
Gasotransmitter hydrogen sulfide signaling in neuronal health and disease
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H2S and its role in redox signaling
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Sulfide regulation of cardiovascular function in health and disease
Kolluru, G. K., Shackelford, R. E., Shen, X., Dominic, P. S., & Kevil, C. G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00741-6 · Cited by 231 · see citing works
Roles of Hydrogen Sulfide in the Pathogenesis of Diabetes Mellitus and Its Complications
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Analytical measurement of discrete hydrogen sulfide pools in biological specimens
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Olson, K. R. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4401 · Cited by 206 · see citing works
Biological chemistry of hydrogen sulfide and persulfides
Cuevasanta, E., Möller, M. N., & Álvarez, B. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.09.018 · Cited by 202 · see citing works
High Turnover Rates for Hydrogen Sulfide Allow for Rapid Regulation of Its Tissue Concentrations
Vitvitsky, V., Kabil, Ö., & Banerjee, R. V. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4310 · Cited by 191 · see citing works
Microbial regulation of host hydrogen sulfide bioavailability and metabolism
Shen, X., Carlström, M., Borniquel, S., Jädert, C., Kevil, C. G., & Lundberg, J. O. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.024 · Cited by 194 · see citing works
Farrugia, G., & Szurszewski, J. H. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.04.041 · Cited by 192 · see citing works
Singh, S., & Banerjee, R. V. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.02.004 · Cited by 188 · see citing works
Electrochemical hydrogen sulfide biosensors
Xu, T., Scafa, N., Xu, L., Zhou, S., Al-Ghanem, K. A., Mahboob, S., Fugetsu, B., & Zhang, X. (2016) · The Analyst · doi:10.1039/c5an02208h · Cited by 187 · see citing works
Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6
Yang, J., Minkler, P. E., Grove, D., Wang, R., Willard, B. B., Dweik, R. A., & Hine, C. (2019) · Communications Biology · doi:10.1038/s42003-019-0431-5 · Cited by 185 · see citing works
Passive loss of hydrogen sulfide in biological experiments
DeLeon, E. R., Stoy, G. F., & Olson, K. R. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.10.016 · Cited by 176 · see citing works
Antioxidant and Cell‐Signaling Functions of Hydrogen Sulfide in the Central Nervous System
Shefa, U., Kim, M., Jeong, N. Y., & Jung, J. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1873962 · Cited by 176 · see citing works
Peake, B. F., Nicholson, C. K., Lambert, J. P., Hood, R. L., Amin, H., Amin, S., & Calvert, J. W. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00796.2012 · Cited by 166 · see citing works
Kabil, Ö., & Banerjee, R. V. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407411 · Cited by 156 · see citing works
Cortese-Krott, M. M., Fernandez, B. O., Santos, J. L. T., Mergia, E., Grman, M., Nagy, P., Kelm, M., Butler, A., & Feelisch, M. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.031 · Cited by 153 · see citing works
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Bailey, T. S., Zakharov, L. N., & Pluth, M. D. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505371z · Cited by 149 · see citing works
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H2S and polysulfide metabolism: Conventional and unconventional pathways
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Miyamoto, R., Koike, S., Takano, Y., Shibuya, N., Kimura, Y., Hanaoka, K., Urano, Y., Ogasawara, Y., & Kimura, H. (2017) · Scientific Reports · doi:10.1038/srep45995 · Cited by 131 · see citing works
Controversies and conundrums in hydrogen sulfide biology
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Kabil, Ö., Vitvitsky, V., & Banerjee, R. V. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105654 · Cited by 127 · see citing works
Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses
Pal, V. K., Bandyopadhyay, P., & Singh, A. (2018) · IUBMB Life · doi:10.1002/iub.1740 · Cited by 122 · see citing works
Direct Proteomic Mapping of Cysteine Persulfidation
Fu, L., Liu, K., He, J., Tian, C., Yu, X., & Yang, J. H. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7777 · Cited by 120 · see citing works
Hydrogen Sulfide Biology and Its Role in Cancer
Khattak, S., Rauf, M. A., Khan, N. H., Zhang, Q.-Q., Chen, H., Muhammad, P., Ansari, M. A., Alomary, M. N., Jahangir, M., Zhang, C., et al. (2022) · Molecules · doi:10.3390/molecules27113389 · Cited by 119 · see citing works
On the chemical biology of the nitrite/sulfide interaction
Cortese-Krott, M. M., Fernandez, B. O., Kelm, M., Butler, A. R., & Feelisch, M. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.12.009 · Cited by 115 · see citing works
Working with “H2S”: Facts and apparent artifacts
Wedmann, R., Bertlein, S., Mačinković, I., Boeltz, S., Miljković, J. L., Munoz, L. E., i, M. H., & Filipović, M. R. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.06.003 · Cited by 110 · see citing works
Li, Z., Guo, L., Feng, Z., Gao, S., Zhang, H., Yang, X., Liu, H., Shao, J., Sun, C., Cheng, Y., et al. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.131995 · Cited by 110 · see citing works
Measurement of H2S In Vivo and In Vitro by the Monobromobimane Method
Shen, X., Kolluru, G. K., Yuan, S. S., & Kevil, C. G. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.11.039 · Cited by 108 · see citing works
Hydrogen Sulfide (H2S)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases
Zhang, L., Wang, Y., Li, Y., Li, L., Xu, S., Feng, X., & Liu, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01066 · Cited by 107 · see citing works
Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
Benchoam, D., Cuevasanta, E., Möller, M. N., & Álvarez, B. (2019) · Antioxidants · doi:10.3390/antiox8020048 · Cited by 105 · see citing works
Physiological Roles of Hydrogen Sulfide and Polysulfides
Kimura, H. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-18144-8_3 · Cited by 99 · see citing works
H2S Analysis in Biological Samples Using Gas Chromatography with Sulfur Chemiluminescence Detection
Vitvitsky, V., & Banerjee, R. V. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.11.013 · Cited by 97 · see citing works
Bazhanov, N., Ansar, M., Ivanciuc, T., Garofalo, R. P., & Casola, A. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0114tr · Cited by 97 · see citing works
Zavaczki, E., Jeney, V., Agarwal, A., Zarjou, A., Oros, M., Katkó, M., Varga, Z., Balla, G., & Balla, J. (2011) · Kidney International · doi:10.1038/ki.2011.212 · Cited by 95 · see citing works
The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease
Wen, Y.-D., Wang, H., & Zhu, Y. Z. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4010395 · Cited by 93 · see citing works
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A direct and selective electrochemical hydrogen sulfide sensor
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Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism
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Yang, G., Li, H., Tang, G., Wu, L., Zhao, K., Cao, Q., Xu, C., & Wang, R. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.12.004 · Cited by 74 · see citing works
Linden, D., Furne, J. K., Stoltz, G. J., Abdel-Rehim, M. S., Levitt, M., & Szurszewski, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01681.x · Cited by 71 · see citing works
Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting
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Interactions of reactive sulfur species with metalloproteins
Domán, A., Dóka, É., Garai, D., Bogdándi, V., Balla, G., Balla, J., & Nagy, P. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102617 · Cited by 67 · see citing works
Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling
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Zhao, Q., Yin, C., Kang, J., Wen, Y., & Huo, F. (2018) · Dyes and Pigments · doi:10.1016/j.dyepig.2018.06.029 · Cited by 62 · see citing works
Low hydrogen sulphide and chronic kidney disease: a dangerous liaison
Perna, A. F., & Ingrosso, D. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr737 · Cited by 55 · see citing works
Hydrogen sulfide as a potential biomarker of asthma
Chung, K. F. (2013) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2014.856267 · Cited by 53 · see citing works
Yadav, P. K., Vitvitsky, V., Carballal, S., Seravalli, J., & Banerjee, R. V. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012616 · Cited by 53 · see citing works
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Niu, W., Wang, J., Qian, J., Wang, M., Wu, P., Chen, F., & Yan, S. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000103 · Cited by 49 · see citing works
Emerging role of hydrogen sulfide-microRNA crosstalk in cardiovascular diseases
Hackfort, B. T., & Mishra, P. K. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00660.2015 · Cited by 47 · see citing works
Robinson, H., & Wray, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046278 · Cited by 44 · see citing works
Faccenda, A., Wang, J., & Mutus, B. (2012) · Analytical Chemistry · doi:10.1021/ac3008863 · Cited by 44 · see citing works
Endothelium as a Source and Target of H2S to Improve Its Trophism and Function
Ciccone, V., Genah, S., & Morbidelli, L. (2021) · Antioxidants · doi:10.3390/antiox10030486 · Cited by 43 · see citing works
Shen, X., Chakraborty, S., Dugas, T. R., & Kevil, C. G. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.06.002 · Cited by 42 · see citing works
Hydrogen sulfide in longevity and pathologies: Inconsistency is malodorous
Sokolov, A. S., Nekrasov, P. V., Shaposhnikov, M. V., & Moskalev, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101262 · Cited by 42 · see citing works
Hydrogen sulfide impairs shear stress-induced vasodilation in mouse coronary arteries
Chai, Q., Lü, T., Wang, X.-L., & Lee, H.-C. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1526-y · Cited by 40 · see citing works
Progress on the reaction-based methods for detection of endogenous hydrogen sulfide
Luo, Y., Zuo, Y., Shi, G., Xiang, H., & Gu, H. C. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03777-8 · Cited by 39 · see citing works
Hydrogen sulfide in stroke: Protective or deleterious?
Chan, S. J., & Wong, P. T. ‐. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.11.015 · Cited by 38 · see citing works
Jurkowska, H., Roman, H. B., Hirschberger, L. L., Sasakura, K., Nagano, T., Hanaoka, K., Krijt, J., & Stipanuk, M. H. (2014) · Amino Acids · doi:10.1007/s00726-014-1700-8 · Cited by 38 · see citing works
Cell-Trappable BODIPY-NBD Dyad for Imaging of Basal and Stress-Induced H2S in Live Biosystems
Ye, H., Sun, L., Pang, Z., Ji, X., Jiao, Y. P., Tu, X., Huang, H., Tang, X., Xi, Z., & Yi, L. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04324 · Cited by 37 · see citing works
Hydrogen sulfide oxidation and the arterial chemoreflex: Effect of methemoglobin
Haouzi, P. A., Bell, H. J., & Philmon, M. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.04.025 · Cited by 36 · see citing works
Ang, A. D., Königstorfer, A., Giles, G. I., & Bhatia, M. (2012) · Advances in Biological Chemistry · doi:10.4236/abc.2012.24044 · Cited by 37 · see citing works
Yu, Y.-P., Chi, X.-L., & Liu, L. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/432318 · Cited by 37 · see citing works
Judenherc‐Haouzi, A., Zhang, X.-Q., Sonobe, T., Song, J., Rannals, M. D., Wang, J., Tubbs, N., Cheung, J. Y., & Haouzi, P. A. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00527.2015 · Cited by 37 · see citing works
Hydrogen Sulfide: Redox Metabolism and Signaling
Banerjee, R. V. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3912 · Cited by 36 · see citing works
Gaseous Signaling Molecules in Cardiovascular Function: From Mechanisms to Clinical Translation
Lee, S. R., Nilius, B., & Han, J. (2018) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2017_7 · Cited by 35 · see citing works
Current approaches for detection of hydrogen sulfide and persulfidation in biological systems
Zhao, D., Zhang, J., Zhou, M., Zhou, H., Gotor, C., Romero, L. C., Shen, J., Yuan, X., & Xie, Y. (2020) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2020.08.006 · Cited by 36 · see citing works
Ci, L., Yang, X., Gu, X., Li, Q., Guo, Y., Zhou, Z., Zhang, M., Shi, J., Yang, H., Wang, Z., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6773 · Cited by 35 · see citing works
Bibli, S., & Fleming, I. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0162 · Cited by 33 · see citing works
Lee, D., Huang, W., Gu, T., & Chang, G. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.04.008 · Cited by 33 · see citing works
Huang, Y., Omorou, M., Gao, M., Mu, C., Xu, W., & Xu, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114506 · Cited by 33 · see citing works
Concurrent Subcellular Delivery of Hydrogen Sulfide and a Payload with Near-Infrared Light
Hanc, K., Janeková, H., & Štacko, P. (2024) · JACS Au · doi:10.1021/jacsau.4c00445 · Cited by 32 · see citing works
Hydrogen Sulfide Promotes Cardiomyocyte Proliferation and Heart Regeneration via ROS Scavenging
Pei, J., Wang, F., Pei, S., Bai, R., Cong, X., Nie, Y., & Chen, X. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1412696 · Cited by 33 · see citing works
Chemiluminescence Measurement of Reactive Sulfur and Nitrogen Species
Li, B., Kim, Y. L., & Lippert, A. R. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0195 · Cited by 32 · see citing works
Gases as Uremic Toxins: Is There Something in the Air?
Jankowski, J., Westhof, T., Vaziri, N. D., Ingrosso, D., & Perna, A. F. (2014) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2014.02.006 · Cited by 31 · see citing works
The Role of Hydrogen Sulphide in Blood Pressure Regulation
Čačányiová, S., Berenyiová, A., & Kristek, F. (2016) · Physiological Research · doi:10.33549/physiolres.933438 · Cited by 31 · see citing works
Physiological roles of hydrogen sulfide and polysulfides
Kimura, H. (2016) · Folia Pharmacologica Japonica · doi:10.1254/fpj.147.23 · Cited by 29 · see citing works
Ding, Y., Li, X., Chen, C., Ling, J., Li, W., Guo, Y., Yan, J., Zha, L., & Cai, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-09960-1 · Cited by 29 · see citing works
Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies
Akbari, M., Söğütdelen, E., Juriasingani, S., & Şener, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2360945 · Cited by 28 · see citing works
Nalli, A. D., Rajagopal, S., Mahavadi, S., Grider, J. R., & Murthy, K. S. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00280.2014 · Cited by 27 · see citing works
- Authors
- Levitt, M. D., Abdel-Rehim, M. S., & Furne, J.
- Affiliations
- University of Minnesota (US)
- Veterans Health Administration (US)
- Corresponding author
- Levitt, Michael D.
- ORCID
- Levitt, Michael D.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-07-15
- Volume
- 15
- Issue
- 2
- Pages
- 373-378
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2058206341
- Cited by
- 177
- References
- 29
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 11 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 15 · 2013: 12 · 2012: 13
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- hydrogen sulfide, gasotransmitters, aorta, vasodilation, intracellular signaling, mouse tissues
- MeSH terms
- Animals, Aorta, Hydrogen Sulfide, Mice
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