The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Nitric Oxide Synthases in Heart Failure
Open accessAbstract
SIGNIFICANCE: The regulation of myocardial function by constitutive nitric oxide synthases (NOS) is important for the maintenance of myocardial Ca(2+) homeostasis, relaxation and distensibility, and protection from arrhythmia and abnormal stress stimuli. However, sustained insults such as diabetes, hypertension, hemodynamic overload, and atrial fibrillation lead to dysfunctional NOS activity with superoxide produced instead of NO and worse pathophysiology. RECENT ADVANCES: Major strides in understanding the role of normal and abnormal constitutive NOS in the heart have revealed molecular targets by which NO modulates myocyte function and morphology, the role and nature of post-translational modifications of NOS, and factors controlling nitroso-redox balance. Localized and differential signaling from NOS1 (neuronal) versus NOS3 (endothelial) isoforms are being identified, as are methods to restore NOS function in heart disease. CRITICAL ISSUES: Abnormal NOS signaling plays a key role in many cardiac disorders, while targeted modulation may potentially reverse this pathogenic source of oxidative stress. FUTURE DIRECTIONS: Improvements in the clinical translation of potent modulators of NOS function/dysfunction may ultimately provide a powerful new treatment for many hearts diseases that are fueled by nitroso-redox imbalance.
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Cites
Nitric oxide synthases: structure, function and inhibition
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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
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Nitric oxide synthases in mammals
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Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
Taylor, A. L., Ziesche, S., Yancy, C., Carson, P., D'Agostino, R., Ferdinand, K., Taylor, M., Adams, K., Sabolinski, M., Worcel, M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042934 · Cited by 1,773
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“Some found HF risk may even increase, as in the HOPE-TOO trial conducted in patients with vascular disease or diabetes-mellitus-prescribed vitamin E (144).”
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
Chen, C.-A., Wang, T.-Y., Varadharaj, S., Reyes, L. A., Hemann, C., Talukder, M. A. H., Chen, Y.-R., Druhan, L. J., & Zweier, J. L. (2010) · Nature · doi:10.1038/nature09599 · Cited by 594
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Impact of Oxypurinol in Patients With Symptomatic Heart Failure
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Self-citation
Cited by
PDE5 inhibitors – pharmacology and clinical applications 20 years after sildenafil discovery
Andersson, K. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14205 · Cited by 445
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease
Lee, D. I., Zhu, G., Sasaki, T., Cho, G.-S., Hamdani, N., Holewinski, R., Jo, S.-H., Danner, T., Zhang, M., Rainer, P. P., et al. (2015) · Nature · doi:10.1038/nature14332 · Cited by 353
Self-citationThe Role of Nrf2 in Cardiovascular Function and Disease
Satta, S., Mahmoud, A. M., Wilkinson, F. L., Yvonne Alexander, M., & White, S. J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9237263 · Cited by 293
Darling, A. L., & Uversky, V. N. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00158 · Cited by 267
Król, M., & Kepinska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010056 · Cited by 187
Metadata
- Authors
- Carnicer, R., Crabtree, M. J., Sivakumaran, V., Casadei, B., & Kass, D. A.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2013-03-20
- Volume
- 18
- Issue
- 9
- Pages
- 1078-1099
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2085111794
- Cited by
- 163
- References
- 16
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- green
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