Nitric oxide synthases in mammals

Nitric oxide: physiology, pathophysiology, and pharmacology.

Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,089 · see citing works

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works

Vascular endothelial cells synthesize nitric oxide from L-arginine

Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,745 · see citing works

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308 · see citing works

Localization of nitric oxide synthase indicating a neural role for nitric oxide

Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981 · see citing works

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540 · see citing works

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107 · see citing works

Neuronal NADPH diaphorase is a nitric oxide synthase.

Hope, B. T., Michael, G. J., Knigge, K. M., & Vincent, S. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2811 · Cited by 1,908 · see citing works

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

Xie, Q. W., Cho, H. J., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A. H., Troso, T., & Nathan, C. (1992) · Science · doi:10.1126/science.1373522 · Cited by 1,888 · see citing works

Histochemical mapping of nitric oxide synthase in the rat brain

Vincent, S. R., & Kimura, H. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90184-4 · Cited by 1,868 · see citing works

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

Rees, D. D., Palmer, R. M. J., Schulz, R., Hodson, H. F., & Moncada, S. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14151.x · Cited by 1,856 · see citing works

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

Dawson, T. M., Bredt, D. S., Fotuhi, M., Hwang, P. M., & Snyder, S. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7797 · Cited by 1,843 · see citing works

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,601 · see citing works

Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite

Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527 · see citing works

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

Knowles, R. G., Palacios‐Callender, M., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5159 · Cited by 1,431 · see citing works

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,348 · see citing works

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.10043 · Cited by 1,097 · see citing works

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

Lamas, S., Marsden, P. A., Li, G. K., Tempst, P., & Michel, T. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6348 · Cited by 982 · see citing works

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 979 · see citing works

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

Hibbs, J. B., Vavrin, Z., & Taintor, R. R. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.2.550 · Cited by 938 · see citing works

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

Feelisch, M., & Noack, E. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90493-6 · Cited by 887 · see citing works

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

Lyons, C., Orloff, G. J., & Cunningham, J. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42704-4 · Cited by 866 · see citing works

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

Geller, D. A., Lowenstein, C. J., Shapiro, R. A., Nussler, A. K., Silvio, M. D., Wang, S. C., Nakayama, D. K., Simmons, R. L., Snyder, S. H., & Billiar, T. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3491 · Cited by 821 · see citing works

Isoforms of nitric oxide synthase Characterization and purification from different cell types

Förstermann, U., Schmidt, H. H. H. W., Pollock, J. S., Sheng, H., Mitchell, J. A., Warner, T. D., Nakane, M., & Murad, F. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90581-o · Cited by 817 · see citing works

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816 · see citing works

Generation of superoxide by purified brain nitric oxide synthase

Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H., & Rosen, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35745-4 · Cited by 750 · see citing works

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

Nishida, K., Harrison, D. G., Navas, J. P., Fisher, A. A., Dockery, S., Uematsu, M., Nerem, R. M., Alexander, R. W., & Murphy, T. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116092 · Cited by 735 · see citing works

Biological Roles of Nitric Oxide

Snyder, S. H., & Bredt, D. S. (1992) · Scientific American · doi:10.1038/scientificamerican0592-68 · Cited by 726 · see citing works

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

Tayeh, M. A., & Marletta, M. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47163-9 · Cited by 687 · see citing works

Calmodulin is a subunit of nitric oxide synthase from macrophages.

Cho, H. J., Xie, Q. W., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., & Nathan, C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.2.599 · Cited by 635 · see citing works

Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases

Salter, M., Knowles, R. G., & Moncada, S. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81123-p · Cited by 630 · see citing works

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

White, K. A., & Marletta, M. A. (1992) · Biochemistry · doi:10.1021/bi00144a001 · Cited by 615 · see citing works

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

Schmidt, H. H. H. W., Gagné, G. D., Nakane, M., Pollock, J. S., MILLER, M. F., & Murad, F. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.10.1382087 · Cited by 610 · see citing works

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

Palmer, R. M. J., & Moncada, S. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(89)80219-0 · Cited by 606 · see citing works

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

Lowenstein, C. J., Glatt, C. S., Bredt, D. S., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6711 · Cited by 605 · see citing works

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

Janssens, S. P., Shimouchi, A., Quertermous, T., Bloch, D. B., & Bloch, K. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42066-2 · Cited by 592 · see citing works

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

Förstermann, U., Pollock, J. S., Schmidt, H. H. H. W., Heller, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1788 · Cited by 592 · see citing works

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

Rees, D. D., Cellek, S., Palmer, R. M. J., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80068-3 · Cited by 590 · see citing works

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

Stuehr, D. J., Kwon, N. S., Nathan, C. F., Griffith, O. W., Feldman, P. L., & Wiseman, J. S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38112-2 · Cited by 575 · see citing works

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

Kwon, N. S., Nathan, C. F., & Stuehr, D. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47089-0 · Cited by 570 · see citing works

The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase

Cross, A. R., & Jones, O. T. G. (1986) · Biochemical Journal · doi:10.1042/bj2370111 · Cited by 551 · see citing works

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

Nakane, M., Schmidt, H. H. H. W., Pollock, J. S., Förstermann, U., & Murad, F. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81210-q · Cited by 546 · see citing works

Inhibition of nitric oxide synthesis by methylene blue

Mayer, B., Brünner, F., & Schmidt, K. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90072-5 · Cited by 536 · see citing works

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

Heinzel, B., John, M., Klatt, P., Böhme, E., & Mayer, B. (1992) · Biochemical Journal · doi:10.1042/bj2810627 · Cited by 530 · see citing works

NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

Buxton, I. L. O., Cheek, D. J., Eckman, D. M., Westfall, D. P., Sanders, K. M., & Keef, K. D. (1993) · Circulation Research · doi:10.1161/01.res.72.2.387 · Cited by 508 · see citing works

Mammalian Nitric Oxide Synthases

Stuehr, D. J., & Griffith, O. W. (1992) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470123119.ch8 · Cited by 507 · see citing works

Molecular cloning and characterization of human endothelial nitric oxide synthase

Marsden, P. A., Schappert, K. T., Chen, H. S., Flowers, M. A., Sundell, C. L., Wilcox, J. N., Lamas, S., & Michel, T. M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80697-f · Cited by 489 · see citing works

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

Sessa, W. C., Harrison, J. K., Barber, C. M., Zeng, D., Durieux, M. E., d’Angelo, D., Lynch, K. R., & Peach, M. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49528-8 · Cited by 469 · see citing works

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1

Stuehr, D. J., Fasehun, O. A., Kwon, N. S., Gross, S. S., Gonzalez, J. A., Levi, R., & Nathan, C. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.1.1703974 · Cited by 465 · see citing works

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

Rosa, M. D., Radomski, M. W., Carnuccio, R., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91583-e · Cited by 454 · see citing works

Purification of a Ca2+/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

Mayer, B., John, M., & Böhme, E. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80848-d · Cited by 449 · see citing works

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

Gross, S. S., & Levi, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35667-9 · Cited by 443 · see citing works

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

Mayer, B., John, M., Heinzel, B., Werner, E. R., WACHTER, H., Schultz, G., & Böhme, E. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81031-3 · Cited by 421 · see citing works

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

Gross, S. S., JAFFE, E. A., Levi, R., & Kilbourn, R. G. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90965-a · Cited by 389 · see citing works

Feedback inhibition of nitric oxide synthase activity by nitric oxide

Assreuy, J., Cunha, F. Q., Liew, F. Y., & Moncada, S. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb12886.x · Cited by 389 · see citing works

Arginine is a physiological precursor of endothelium-derived nitric oxide

Schmidt, H. H. H. W., Nau, H., Wittfoht, W., Gerlach, J. C., Prescher, K.-E., Klein, M. M., Niroomand, F., & Böhme, E. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90101-x · Cited by 389 · see citing works

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat

Knowles, R. G., Merrett, M., Salter, M., & Moncada, S. (1990) · Biochemical Journal · doi:10.1042/bj2700833 · Cited by 388 · see citing works

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

Knowles, R. G., Salter, M., Brooks, S. L., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91551-3 · Cited by 384 · see citing works

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Förstermann, U., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.365 · Cited by 381 · see citing works

Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney

Ogawa, T., Kimoto, M., & Sasaoka, K. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81786-0 · Cited by 364 · see citing works

Nitric oxide synthase: Irreversible inhibition by L-N -Nitroarginine in brain and

Dwyer, M. A., Bredt, D. S., & Snyder, S. H. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90403-t · Cited by 360 · see citing works

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

Stuehr, D. J., & Ikeda‐Saito, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36718-3 · Cited by 348 · see citing works

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

Nunokawa, Y., Ishida, N., & Tanaka, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1188 · Cited by 317 · see citing works

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

Charles, I. G., Palmer, R. M. J., Hickery, M. S., Bayliss, M. T., Chubb, A., Hall, V. S., Moss, D. W., & Moncada, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11419 · Cited by 291 · see citing works

Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.

Leone, A., Palmer, R. M. J., Knowles, R. G., Francis, P. L., Ashton, D., & Moncada, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54352-0 · Cited by 290 · see citing works

The transport of cationic amino acids across the plasma membrane of mammalian cells

White, M. F. (1985) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(85)90015-2 · Cited by 289 · see citing works

Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.

Werner‐Felmayer, G., Werner, E. R., Fuchs, D., Hausen, A., Reibnegger, G. J., & WACHTER, H. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1599 · Cited by 287 · see citing works

Induction of Nitric Oxide Synthase in Human Chondrocytes

Palmer, R. M. J., Hickery, M. S., Charles, I. G., Moncada, S., & Bayliss, M. T. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1637 · Cited by 281 · see citing works

Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine

Furfine, E. S., Harmon, M. F., Paith, J. E., & Garvey, E. P. (1993) · Biochemistry · doi:10.1021/bi00084a017 · Cited by 280 · see citing works

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

Nakane, M., Mitchell, J. A., Förstermann, U., & Murad, F. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81351-8 · Cited by 274 · see citing works

Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase

Mayer, B., Schmidt, K., Humbert, P., & Böhme, E. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91513-1 · Cited by 271 · see citing works

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

Gross, S. S., Stuehr, D. J., Aisaka, K., JAFFE, E. A., Levi, R., & Griffith, O. W. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91245-n · Cited by 269 · see citing works

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

Rogers, N. E., & Ignarro, L. J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91550-a · Cited by 252 · see citing works

Identification of N‐iminoethyl‐ l ‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

McCall, T., Feelisch, M., Palmer, R. M. J., & Moncada, S. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12159.x · Cited by 252 · see citing works

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

Kwon, N. S., Nathan, C. F., Gilker, C. D., Griffith, O. W., Matthews, D. E., & Stuehr, D. J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77366-3 · Cited by 247 · see citing works

Purification of nitric oxide synthase from rat macrophages

Yui, Y., Hattori, R., Kosuga, K., Eizawa, H., Hiki, K., & Kawai, C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98932-5 · Cited by 243 · see citing works

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

Palacios‐Callender, M., Knowles, R. G., Palmer, R. M. J., & Moncada, S. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(89)80037-3 · Cited by 237 · see citing works

Kinetic characteristics of nitric oxide synthase from rat brain

Knowles, R. G., Palacios‐Callender, M., Palmer, R. M. J., & Moncada, S. (1990) · Biochemical Journal · doi:10.1042/bj2690207 · Cited by 202 · see citing works

Endothelial cells metabolize NG -monomethyl-L-arginine to L-citrulline and subsequently to L-arginine

Hecker, M., Mitchell, J. A., Harris, H. J., Katsura, M., Thiemermann, C., & Vane, J. R. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90627-y · Cited by 184 · see citing works

Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts.

White, M. F., Gazzola, G. C., & Christensen, H. N. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34742-2 · Cited by 180 · see citing works

Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine

Bush, P. A., Gonzalez, N. E., Griscavage, J. M., & Ignarro, L. J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91720-b · Cited by 179 · see citing works

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

Billiar, T. R., CURRAN, R. D., Stuehr, D. J., Stadler, J., Simmons, R. L., & Murray, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91133-d · Cited by 175 · see citing works

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l ‐arginine transporter

Bogle, R., Moncada, S., Pearson, J. D., & Mann, G. E. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09053.x · Cited by 169 · see citing works

Immunological detection of nitric oxide synthase(s) in human tissues using heterologous antibodies suggesting different isoforms

Springall, D. R., Riveros‐Moreno, V., Buttery, L. D. K., Suburo, Á. M., Bishop, A. E., Merrett, M., Moncada, S., & Polak, J. M. (1992) · Histochemistry and Cell Biology · doi:10.1007/bf00271040 · Cited by 168 · see citing works

Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.

Sessa, W. C., Barber, C. M., & Lynch, K. R. (1993) · Circulation Research · doi:10.1161/01.res.72.4.921 · Cited by 166 · see citing works

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

Schmidt, K., Werner, E. R., Mayer, B., WACHTER, H., & Kukovetz, W. R. (1992) · Biochemical Journal · doi:10.1042/bj2810297 · Cited by 164 · see citing works

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