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Cited by 59Phagocytosis and Immune RegulationHeme Oxygenase-1 and Carbon MonoxideAldose Reductase and Taurine

Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide

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Kim, Wonki, Kim, Hoon-Ui, Lee, Ha-Na, Kim, Seung Hyeon, Kim, Chaekyun, Cha, Young-Nam, Joe, Yeonsoo, Chung, Hun Taeg +6 more·2015·Antioxidants & Redox Signaling
DOI 10.1089/ars.2013.5825PMC PMC4492774
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Abstract

Aims: To examine the pro-resolving effects of taurine chloramine (TauCl). Results: TauCl injected into the peritoneum of mice enhanced the resolution of zymosan A-induced peritonitis. Furthermore, when the macrophages obtained from peritoneal exudates were treated with TauCl, their efferocytic ability was elevated. In the murine macrophage-like RAW264.7 cells exposed to TauCl, the proportion of macrophages engulfing the apoptotic neutrophils was also increased. In these macrophages treated with TauCl, expression of heme oxygenase-1 (HO-1) was elevated along with increased nuclear translocation of the nuclear factor E2-related factor 2 (Nrf2). TauCl binds directly to Kelch-like ECH association protein 1 (Keap1), which appears to retard the Keap1-driven degradation of Nrf2. This results in stabilization and enhanced nuclear translocation of Nrf2 and upregulation of HO-1 expression. TauCl, when treated to peritoneal macrophages isolated from either Nrf2 or HO-1 wild-type mice, stimulated efferocytosis (phagocytic engulfment of apoptotic neutrophils by macrophages), but not in the macrophages from Nrf2 or HO-1 knockout mice. Furthermore, transcriptional expression of some scavenger receptors recognizing the phosphatidylserines exposed on the surface of apoptotic cells was increased in RAW264.7 cells treated with TauCl. Pharmacologic inhibition of HO-1 activity or knockdown of HO-1 gene in RAW264.7 cells abolished the TauCl-induced efferocytosis, whereas both overexpression of HO-1 and treatment with carbon monoxide (CO), the product of HO, potentiated the efferocytic activity of macrophages. Innovation: This work provides the first evidence that TauCl stimulates efferocytosis by macrophages. The results of this study suggest the therapeutic potential of TauCl in the management of inflammatory disorders. Conclusion: TauCl can facilitate resolution of inflammation by increasing the efferocytic activity of macrophages through Nrf2-mediated HO-1 upregulation and subsequent production of CO. Antioxid. Redox Signal. 23, 163–177.

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Authors
Kim, W., Kim, H.-U., Lee, H.-N., Kim, S. H., Kim, C., Cha, Y.-N., Joe, Y., Chung, H. T., Jang, J., Kim, K., Suh, Y.-G., Jin, H.-O., Lee, J. K., & Surh, Y.-J.
Affiliations
  • Seoul National University
  • Seoul National University (KR)
  • Inha University (KR)
  • University of Ulsan (KR)
  • Korea Institute of Radiological and Medical Sciences (KR)
Corresponding author
Surh, Young-Joon
ORCID
Venue
Antioxidants & Redox Signaling
Publisher
SAGE Publications
Published
2015-07
Volume
23
Issue
2
Pages
163-177
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
DOI
10.1089/ars.2013.5825
PMC
PMC4492774
OpenAlex
W2315810631
Cited by
59
References
1
Citations by year
2026: 4 · 2025: 8 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 4
FWCI
1.97
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Antioxidants and Redox Signaling (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords
taurine chloramine, efferocytosis, Nrf2, heme oxygenase-1, carbon monoxide, macrophages, inflammation resolution, Keap1, apoptotic neutrophils, scavenger receptors, phosphatidylserine
MeSH terms
Kelch-Like ECH-Associated Protein 1, Animals, Carbon Monoxide, Cytoskeletal Proteins, Disease Models, Animal, Humans, Inflammation, Macrophages, Phagocytosis, Taurine, Zymosan, Up-Regulation, Macrophages, Peritoneal, Jurkat Cells, Adaptor Proteins, Signal Transducing, NF-E2-Related Factor 2, Mice, Heme Oxygenase-1

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