Nrf2 signaling pathway: pivotal roles in inflammation

Ahmed, Syed Minhaj Uddin; Luo, Lin; Namani, Akhileshwar; Wang, Xiu Jun; Tang, Xiuwen

doi:10.1016/j.bbadis.2016.11.005

Cited by 1,794Genomics, phytochemicals, and oxidative stressNF-κB Signaling PathwaysNatural Compounds in Disease Treatment

Nrf2 signaling pathway: pivotal roles in inflammation

Open access

Ahmed, Syed Minhaj Uddin, Luo, Lin, Namani, Akhileshwar, Wang, Xiu Jun, Tang, Xiuwen·2017·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2016.11.005

Open this paper in CoChat — free account Open PDF

Abstract

Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process by orchestrating the recruitment of inflammatory cells and regulating gene expression through the antioxidant response element (ARE). The Keap1 (Kelch-like ECH-associated protein)/Nrf2 (NF-E2 p45-related factor 2)/ARE signaling pathway mainly regulates anti-inflammatory gene expression and inhibits the progression of inflammation. Therefore, the identification of new Nrf2-dependent anti-inflammatory phytochemicals has become a key point in drug discovery. In this review, we discuss the members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway. In addition we also discuss about the regulation of NLRP3 inflammasome by Nrf2. Besides this, we summarize the current scenario of the development of anti-inflammatory phytochemicals and others that mediate the Nrf2/ARE signaling pathway.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.bbadis.2016.11.005

Cites

168 of 168 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The anti-oxidant, anti-inflammatory, and cytoprotective effects of Nrf2 have been shown in various studies.
“The anti-oxidant, anti-inflammatory, and cytoprotective effects of Nrf2 have been shown in various studies (30).”
From Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway (2019) · cites this paper as [30]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,418 · see citing works
Inflammasomes in health and disease
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,158 · see citing works
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., Hayashi, M., Sekine, H., Tanaka, N., Moriguchi, T., Motohashi, H., Nakayama, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms11624 · Cited by 1,878 · see citing works
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118976 · Cited by 1,472 · see citing works
Molecular mechanisms regulating NLRP3 inflammasome activation
Jo, E.-K., Kim, J. K., Shin, D.-M., & Sasakawa, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.95 · Cited by 1,378 · see citing works
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
Zhang, D. D., Lo, S., Cross, J. V., Templeton, D. J., & Hannink, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10941-10953.2004 · Cited by 1,262 · see citing works
Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation
Ferrero‐Miliani, L., Nielsen, O. H., Andersen, P. S., & Girardin, S. E. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03261.x · Cited by 1,102 · see citing works
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
Balogun, E. A., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J., & Motterlini, R. (2003) · Biochemical Journal · doi:10.1042/bj20021619 · Cited by 1,038 · see citing works
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
Thimmulappa, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25790 · Cited by 1,028 · see citing works
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
Rangasamy, T., Cho, C. Y., Thimmulappa, R. K., Zhen, L., Srisuma, S., Kensler, T. W., Yamamoto, M. P., Petrache, I., Tuder, R. M., & Biswal, S. S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21146 · Cited by 993 · see citing works
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase
Cullinan, S. B., Gordan, J. D., Jin, J., Harper, J. W., & Diehl, J. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8477-8486.2004 · Cited by 986 · see citing works
Chronic Inflammation and Oxidative Stress as a Major Cause of Age- Related Diseases and Cancer
Khansari, N., Shakiba, Y., & Mahmoudi, M. (2009) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/187221309787158371 · Cited by 922 · see citing works
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
Lau, A., Wang, X.-J., Zhao, F. L., Villeneuve, N. F., Wu, T., Jiang, T., Sun, Z., White, E., & Zhang, D. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00248-10 · Cited by 851 · see citing works
Self-citation
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
Malhotra, D., Portales-Casamar, É., Singh, A., Srivastava, S., Arenillas, D. J., Happel, C., Shyr, C., Wakabayashi, N., Kensler, T. W., Wasserman, W. W., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq212 · Cited by 796 · see citing works
SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
Rada, P., Rojo, A. I., Chowdhry, S., McMahon, M., Hayes, J. D., & Cuadrado, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01204-10 · Cited by 759 · see citing works
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow
Yang, L., Froio, R. M., Sciuto, T. E., Dvořàk, A. M., Alon, R., & Luscinskas, F. W. (2005) · Blood · doi:10.1182/blood-2004-12-4942 · Cited by 720 · see citing works
NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
Liu, G.-H., Qu, J., & Shen, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.002 · Cited by 697 · see citing works
Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention
Kaulmann, A., & Bohn, T. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.07.010 · Cited by 675 · see citing works
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
Chowdhry, S., Zhang, Y., McMahon, M., Sutherland, C., Cuadrado, A., & Hayes, J. D. (2013) · Oncogene · doi:10.1038/onc.2012.388 · Cited by 657 · see citing works
Nuclear Factor κB Is a Molecular Target for Sulforaphane-mediated Anti-inflammatory Mechanisms
Heiß, E. H., Herhaus, C., Klimo, K., Bartsch, H., & Gerhäuser, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104794200 · Cited by 633 · see citing works
Structural basis of Keap1 interactions with Nrf2
Canning, P., Sorrell, F. J., & Bullock, A. N. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.034 · Cited by 605 · see citing works
When NRF2 Talks, Who's Listening?
Wakabayashi, N., Slocum, S. L., Skoko, J. J., Shin, S., & Kensler, T. W. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3216 · Cited by 595 · see citing works
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050538 · Cited by 580 · see citing works
Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors
Brigelius-Flohé, R., & Flohé, L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3534 · Cited by 577 · see citing works
Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
Hayes, J. D., McMahon, M. J., Chowdhry, S., & Dinkova‐Kostova, A. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3221 · Cited by 540 · see citing works
Nrf2-Deficient Mice Have an Increased Susceptibility to Dextran Sulfate Sodium–Induced Colitis
Khor, T. O., Huang, M., Kwon, K. H., Chan, J. Y., Reddy, B. S., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3562 · Cited by 530 · see citing works
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., & Yamamoto, M. P. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00469.x · Cited by 521 · see citing works
The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation
Innamorato, N. G., Rojo, A. I., García‐Yagüe, Á. J., Yamamoto, M. P., CEBALLOS, M. L. D., & Cuadrado, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.680 · Cited by 479 · see citing works
Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation
Soares, M. P., Seldon, M. P., Grégoire, I. P., Vassilevskaia, T. D., Berberat, P. O., Yu, J. H., Tsui, T., & Bach, F. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3553 · Cited by 464 · see citing works
Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response
Tong, K. I., Padmanabhan, B., Kobayashi, A., Shang, C., Hirotsu, Y., Yokoyama, S., & Yamamoto, M. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00753-07 · Cited by 447 · see citing works
Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
Chen, X.-L., Dodd, G., Thomas, S., Zhang, X., Wasserman, M. A., Rovin, B. H., & Kunsch, C. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00651.2005 · Cited by 418 · see citing works
Nrf2 Transcription Factor, a Novel Target of Keratinocyte Growth Factor Action Which Regulates Gene Expression and Inflammation in the Healing Skin Wound
Braun, S., Hanselmann, C., Gassmann, M. G., auf dem Keller, U., Born-Berclaz, C., Chan, K., Kan, Y. W., & Werner, S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5492-5505.2002 · Cited by 410 · see citing works
Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2
Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.36-45.2004 · Cited by 407 · see citing works
KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ
Lee, D.-F., Kuo, H.-P., Liu, M., Chou, C.-K., Xia, W., Du, Y., Shen, J., Chen, C.-T., Huo, L., Hsu, M.-C., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.07.025 · Cited by 399 · see citing works
The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation
Nioi, P., Nguyen, T., Sherratt, P. J., & Pickett, C. B. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10895-10906.2005 · Cited by 383 · see citing works
RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
Wang, H., Liu, K., Geng, M., Gao, P., Wu, X., Hai, Y., Li, Y., Li, Y., Luo, L., Hayes, J. D., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3386 · Cited by 382 · see citing works
Self-citation
Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
Rojo, A. I., Innamorato, N. G., Martín-Moreno, A. M., CEBALLOS, M. L. D., Yamamoto, M. P., & Cuadrado, A. (2009) · Glia · doi:10.1002/glia.20947 · Cited by 381 · see citing works
The Rel/NF-κB family: friend and foe
Perkins, N. D. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01617-0 · Cited by 373 · see citing works
microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
Sangokoya, C., Telen, M. J., & Chi, J. (2010) · Blood · doi:10.1182/blood-2009-04-214817 · Cited by 357 · see citing works
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
Thimmulappa, R. K., Scollick, C., Traore, K., Yates, M. S., Trush, M. A., Liby, K. T., Sporn, M. B., Yamamoto, M. P., Kensler, T. W., & Biswal, S. S. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.102 · Cited by 356 · see citing works
The transcription factor NRF2 protects against pulmonary fibrosis
Cho, H., Reddy, S. P., Yamamoto, M. P., & Kleeberger, S. R. (2004) · The FASEB Journal · doi:10.1096/fj.03-1127fje · Cited by 355 · see citing works
Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells
Chen, X.-L., Varner, S. E., Rao, A. S., Grey, J. Y., Thomas, S., Cook, C. K., Wasserman, M. A., Medford, R. M., Jaiswal, A. K., & Kunsch, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203161200 · Cited by 333 · see citing works
Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
Lin, W., Wu, R. T., Wu, T., Khor, T.-O., Wang, H., & Kong, A. T. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.07.036 · Cited by 324 · see citing works
Parallel Induction of Heme Oxygenase-1 and Chemoprotective Phase 2 Enzymes by Electrophiles and Antioxidants: Regulation by Upstream Antioxidant-Responsive Elements (ARE)
Prestera, T., Talalay, P., Alam, J., Ahn, Y. I., Lee, P. J., & Choi, A. M. K. (1995) · Molecular Medicine · doi:10.1007/bf03401897 · Cited by 305 · see citing works
Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
Freigang, S., Ampenberger, F., Spohn, G., Heer, S., Shamshiev, A. T., Kisielow, J., Hersberger, M., Yamamoto, M., Bachmann, M. F., & Kopf, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041316 · Cited by 300 · see citing works
Inflammasomes in cancer: a double-edged sword
Kolb, R. H., Liu, G., Janowski, A. M., Sutterwala, F. S., & Zhang, W. (2013) · Protein & Cell · doi:10.1007/s13238-013-0001-4 · Cited by 294 · see citing works
MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
Yang, M., Yao, Y., Eades, G. L., Zhang, Y., & Zhou, Q. Y. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1604-1 · Cited by 280 · see citing works
Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation
Tsai, P., Ka, S., Chang, J., Chen, H., Shui, H., Li, C., Hua, K., Chang, W.-L., Huang, J., Yang, S., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.016 · Cited by 268 · see citing works
Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats
Lanone, S., Bloc, S., Foresti, R., Almolki, A., Taillé, C., Callebert, J., Conti, M., Goven, D., Aubier, M., Dureuil, B., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2368fje · Cited by 261 · see citing works
Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway
Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., Foster, B. J., Goldring, C. E., & Park, B. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096545 · Cited by 260 · see citing works
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
Chowdhry, S., Nazmy, M., Meakin, P. J., Dinkova‐Kostova, A. T., Walsh, S. V., Tsujita, T., Dillon, J. F., Ashford, M. L. J., & Hayes, J. D. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.007 · Cited by 260 · see citing works
Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming
Liu, X., Zhang, X., Ding, Y., Zhou, W., Tao, L., Lü, P., Wang, Y., & Hu, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6615 · Cited by 259 · see citing works
Retinal Ischemia and Reperfusion Causes Capillary Degeneration: Similarities to Diabetes
Zheng, L., Gong, B., Hatala, D. A., & Kern, T. S. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0510 · Cited by 256 · see citing works
Nrf1 and Nrf2 Regulate Rat Glutamate-Cysteine Ligase Catalytic Subunit Transcription Indirectly via NF-κB and AP-1
Yang, H., Magilnick, N., Lee, C., Kalmaz, D. M., Ou, X., Chan, J. Y., & Lu, S. C.-L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.5933-5946.2005 · Cited by 250 · see citing works
Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema
Ishii, Y., Itoh, K., Morishima, Y., Kimura, T., Kiwamoto, T., IIzuka, T., Hegab, A. E., Hosoya, T., Nomura, A., Sakamoto, T., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6968 · Cited by 248 · see citing works
Bilirubin From Heme Oxygenase-1 Attenuates Vascular Endothelial Activation and Dysfunction
Kawamura, K., Ishikawa, K., Wada, Y., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000148405.18071.6a · Cited by 244 · see citing works
Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179
Ahmad, R., Raina, D. B., Meyer, C. J., Kharbanda, S. M., & Kufe, D. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607160200 · Cited by 238 · see citing works
Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response
Jiang, T., Tian, F., Zheng, H., Whitman, S. A., Lin, Y., Zhang, Z., Zhang, N., & Zhang, D. D. (2013) · Kidney International · doi:10.1038/ki.2013.343 · Cited by 233 · see citing works
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
Zhou, S.-F., Wang, Y., Zhe, H., Yang, Y., & He, Z. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s68872 · Cited by 230 · see citing works
Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity
Bellezza, I., Tucci, A., Galli, F., Grottelli, S., Mierla, A. L., Pilolli, F., & Minelli, A. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.10.012 · Cited by 216 · see citing works
Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats
Wang, W. W., Smith, D. L. H., & Zucker, S. D. (2004) · Hepatology · doi:10.1002/hep.20334 · Cited by 213 · see citing works
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China
Egner, P. A., Chen, J., Wang, J. B., Wu, Y., Sun, Y., Lu, J. H., Zhu, J., Zhang, Y. H., Chen, Y. S., Friesen, M. D., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0296 · Cited by 213 · see citing works
Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study
Samsamikor, M., Daryani, N. E., Rezanejad-Asl, P., & Hekmatdoost, A. (2015) · Archives of Medical Research · doi:10.1016/j.arcmed.2015.05.005 · Cited by 208 · see citing works
Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells
Narasimhan, M., Patel, D., Vedpathak, D., Rathinam, M., Henderson, G. I., & Mahimainathan, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051111 · Cited by 201 · see citing works
Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
Lv, H., Yu, Z., Zheng, Y., Wang, L., Qin, F. X.-F., Cheng, G., & Ci, X. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.13188 · Cited by 201 · see citing works
MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis
Singh, B. P., Ronghe, A. M., Chatterjee, A., Bhat, N. K., & Bhat, H. K. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt026 · Cited by 200 · see citing works
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2‐deficient mice upon dextran sulfate treatment
Osburn, W. O., Karim, B. O., Dolan, P. M., Liu, G., Yamamoto, M. P., Huso, D. L., & Kensler, T. W. (2007) · International Journal of Cancer · doi:10.1002/ijc.22943 · Cited by 197 · see citing works
Nrf2 Gene Transfer Induces Antioxidant Enzymes and Suppresses Smooth Muscle Cell Growth In Vitro and Reduces Oxidative Stress in Rabbit Aorta In Vivo
Levonen, A., Inkala, M., Heikura, T., Jauhiainen, S., Jyrkkänen, H.-K., Kansanen, E., Määttä, K. M., Romppanen, E., Turunen, P., Rutanen, J., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000258868.80079.4d · Cited by 189 · see citing works
Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease
Cho, H., Imani, F., Miller‐DeGraff, L., Walters, D. M., Melendi, G. A., Yamamoto, M. P., Polack, F. P., & Kleeberger, S. R. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-535oc · Cited by 189 · see citing works
A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis–Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study
Wagenlehner, F. R. A., Schneider, H., Ludwig, M., et al. (2009) · European Urology · doi:10.1016/j.eururo.2009.05.046 · Cited by 186 · see citing works
Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation
Zhao, C., Gillette, D. D., Li, X., Zhang, Z., & Wen, H. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.563114 · Cited by 185 · see citing works
Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling
Narayanan, S., Kalayarasan, S., & Sudhandiran, G. (2008) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2008.12.010 · Cited by 174 · see citing works
Safety of an Astaxanthin-Rich Haematococcus pluvialis Algal Extract: A Randomized Clinical Trial
Spiller, G. A., & Dewell, A. (2003) · Journal of Medicinal Food · doi:10.1089/109662003765184741 · Cited by 171 · see citing works
Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial
Mielgo‐Ayuso, J., Barrenechea, L., Alcorta, P., Larrarte, E., Margareto, J., & Labayen, I. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003784 · Cited by 171 · see citing works
Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice
Reddy, N. M., Kleeberger, S. R., Kensler, T. W., Yamamoto, M. P., Hassoun, P. M., & Reddy, S. P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804248 · Cited by 159 · see citing works
Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease
Choi, B.-H., Kang, K.-S., & Kwak, M. (2014) · Molecules · doi:10.3390/molecules190812727 · Cited by 159 · see citing works
Unconjugated Bilirubin Inhibits VCAM-1-Mediated Transendothelial Leukocyte Migration
Keshavan, P., Deem, T. L., Schwemberger, S. J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3709 · Cited by 159 · see citing works
Nrf2 Possesses a Redox-sensitive Nuclear Exporting Signal in the Neh5 Transactivation Domain
Li, W., Yu, S., & Kong, A.-N. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602746200 · Cited by 157 · see citing works
Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial
Heinz, S. A., Henson, D. A., Austin, M. D., Jin, F., & Nieman, D. C. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.05.001 · Cited by 152 · see citing works
Impact of Nrf2 on UVB‐induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
Saw, C. L. L., Huang, M., Liu, Y., Khor, T. O., Conney, A. H., & Kong, A. T. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20725 · Cited by 148 · see citing works
Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation
Liu, X., Zhou, W., Zhang, X., Lü, P., Du, Q., Tao, L., Ding, Y., Wang, Y., & Hu, R. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.05.002 · Cited by 146 · see citing works
NF-κB, Nrf2, and HO-1 Interplay in Redox-Regulated VCAM-1 Expression
Banning, A., & Brigelius‐Flohé, R. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.889 · Cited by 143 · see citing works
Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury
Wei, Y., Gong, J., Yoshida, T., Eberhart, C. G., Xu, Z., Kombairaju, P., Sporn, M. B., Handa, J. T., & Duh, E. J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.026 · Cited by 143 · see citing works
Nrf2 Induces Interleukin-6 (IL-6) Expression via an Antioxidant Response Element within the IL-6 Promoter
Wruck, C. J., Streetz, K. L., Pavic, G., Götz, M. E., Tohidnezhad, M., Brandenburg, L., Varoga, D. J., Eickelberg, O., Herdegen, T., Trautwein, C., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.162008 · Cited by 135 · see citing works
Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis
Liu, Y., Zhu, B., Wang, X., Luo, L., Li, P., Paty, D. W., & Cynader, M. S. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00132-2 · Cited by 135 · see citing works
Self-citation
Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A double-blind placebo-controlled study
Sakata, R., Nakamura, T., Torimura, T., Ueno, T., & Sata, M. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1503 · Cited by 134 · see citing works
Up-down Regulation of HO-1 and iNOS Gene Expressions by Ethyl Pyruvate via Recruiting p300 to Nrf2 and Depriving It from p65
Kim, S.-W., Lee, H., Shin, J., & Lee, J.-K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.028 · Cited by 129 · see citing works
Epigallocatechin gallate attenuates amyloid β-induced inflammation and neurotoxicity in EOC 13.31 microglia
Wei, J. C., Huang, H., Chen, W. J., Huang, C., Peng, C., & Lin, C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.048 · Cited by 128 · see citing works
Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
Namani, A., Li, Y., Wang, X. J., & Tang, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.003 · Cited by 126 · see citing works
Self-citation
Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin
Boyanapalli, S. S. S., Paredes‐Gonzalez, X., Fuentes, F., Zhang, C., Guo, Y., Pung, D., Saw, C. L. L., & Kong, A. T. (2014) · Chemical Research in Toxicology · doi:10.1021/tx500234h · Cited by 113 · see citing works
Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels
Morito, N., Yoh, K., Itoh, K., Hirayama, A., Kôyama, A., Yamamoto, M. P., & Takahashi, S. (2003) · Oncogene · doi:10.1038/sj.onc.1207024 · Cited by 112 · see citing works
The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains
Kim, J.-H., Yu, S., Chen, J. D., & Kong, A.-N. T. (2012) · Oncogene · doi:10.1038/onc.2012.59 · Cited by 110 · see citing works
Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease
Maicas, N., Ferrándiz, M. L., Brines, R., Ibáñez, L., Cuadrado, A., Koenders, M. I., van den Berg, W. B., & Alcaraz, M. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3835 · Cited by 110 · see citing works
The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders
Hybertson, B. M., Gao, B., & Doan, A. (2014) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s35078 · Cited by 110 · see citing works
The NRF2‐related interactome and regulome contain multifunctional proteins and fine‐tuned autoregulatory loops
Papp, D., Lenti, K., Módos, D., Fazekas, D., Dúl, Z., Türei, D., Földvári-Nagy, L., Nussinov, R., Csermely, P., & Korcsmaros, T. D. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.016 · Cited by 109 · see citing works
Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation
Keleku-Lukwete, N., Suzuki, M., Otsuki, A., Tsuchida, K., Katayama, S., Hayashi, M., Naganuma, E., Moriguchi, T., Tanabe, O., Engel, J. D., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509158112 · Cited by 108 · see citing works
Silymarin in treatment of non-alcoholic steatohepatitis: A randomized clinical trial.
Solhi, H., Ghahremani, R., Kazemifar, A. M., & Yazdi, Z. H. (2014) · Europe PMC (PubMed Central) · Cited by 107 · see citing works
Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
Liu, X., Liu, X., Wang, T., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.06.009 · Cited by 107 · see citing works
Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis
Pareek, T. K., Belkadi, A., Kesavapany, S., Zaremba, A., Loh, S. L., Bai, L., Cohen, M. L., Meyer, C. J., Liby, K. T., Miller, R. H., et al. (2011) · Scientific Reports · doi:10.1038/srep00201 · Cited by 106 · see citing works
Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity
Zhu, G., Guo, H., Huang, Y. X., Wu, C., & ZHANG, X.-F. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2827 · Cited by 104 · see citing works
2′,4′,6′-Tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-α-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways
Lee, S. H., Sohn, D. H., Jin, X. Y., Kim, S. W., Choi, S. C., & Seo, G. S. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.034 · Cited by 101 · see citing works
Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation
Ka, S., Lin, J., Lin, T.-J., Liu, F., Chao, L. K., Ho, C., Yeh, L., Sytwu, H., Hua, K., & Chen, A. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0844-6 · Cited by 100 · see citing works
Elevation of HO-1 Expression Mitigates Intestinal Ischemia-Reperfusion Injury and Restores Tight Junction Function in a Rat Liver Transplantation Model
Chi, X., Yao, W., Xia, H., Jin, Y., Li, X., Cai, J., & Hei, Z. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/986075 · Cited by 99 · see citing works
Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages
Saw, C. L. L., Yang, Y., Huang, M., Liu, Y., Lee, J. H., Khor, T. O., Su, Z., Shu, L., Lu, Y., Conney, A. H., et al. (2014) · Cell & Bioscience · doi:10.1186/2045-3701-4-39 · Cited by 95 · see citing works
Resveratrol: Why Is It a Promising Therapy for Chronic Kidney Disease Patients?
Saldanha, J. F., Leal, V. D. O., Stenvinkel, P., Carraro-Eduardo, J. C., & Mafra, D. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/963217 · Cited by 93 · see citing works
Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2–ARE as an indicator and modulator of redox
Aboonabi, A., & Singh, I. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.03.008 · Cited by 92 · see citing works
The Heme Oxygenase System: Its Role in Liver Inflammation
Wunder, C., & Potter, R. F. (2003) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1568006033481410 · Cited by 92 · see citing works
Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects
He, L., Peng, X., Zhu, J., Chen, X., Liu, H., Tang, C., Dong, Z., Liu, F., & Peng, Y. (2014) · American Journal of Nephrology · doi:10.1159/000369220 · Cited by 92 · see citing works
Neuroprotective Effects of Sulforaphane after Contusive Spinal Cord Injury
Benedict, A. L., Mountney, A., Hurtado, A., Bryan, K. E., Schnaar, R. L., Dinkova‐Kostova, A. T., & Talalay, P. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2474 · Cited by 91 · see citing works
Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile
Liu, Y., Hsieh, C., Wu, C.-C., & Wung, B. (2007) · Life Sciences · doi:10.1016/j.lfs.2006.12.040 · Cited by 87 · see citing works
3-Hydroxyanthranilic acid, one of l-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells
Pae, H., Oh, G., Lee, B.-S., Rim, J.-S., Kim, Y., & Chung, H. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.09.010 · Cited by 84 · see citing works
Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages
Kuhn, A.-M., Tzieply, N., Schmidt, M. V., von Knethen, A., Namgaladze, D., Yamamoto, M. P., & Brüne, B. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.02.036 · Cited by 83 · see citing works
The relationship between Helicobacter pylori infection and promoter polymorphism of the Nrf2 gene in chronic gastritis
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Hasegawa, S., Takagi, T., Wang, F.-Y., et al. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.19.1.143 · Cited by 82 · see citing works
Stem Cell Therapy and Curcumin Synergistically Enhance Recovery from Spinal Cord Injury
Ormond, D. R., Shannon, C. M., Oppenheim, J. J., Zeman, R. J., Das, K., Murali, R., & Jhanwar‐Uniyal, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088916 · Cited by 82 · see citing works
Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation
Li, C., Jin, H., Sun, H., Zhang, Z.-Z., Zheng, J., Li, S., & Han, S.-H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.12.042 · Cited by 81 · see citing works
Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs
Wang, X. J., Li, Y., Luo, L., Wang, H., Chi, Z., Xin, A., Li, X., Wu, J., & Tang, X. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.02.010 · Cited by 80 · see citing works
Self-citation
STAT signaling in inflammation
Kaplan, M. H. (2013) · JAK-STAT · doi:10.4161/jkst.24198 · Cited by 80 · see citing works
Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
Gill, A. J., & Kolson, D. L. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013007247 · Cited by 80 · see citing works
Nrf2 is a critical modulator of the innate immune response in a model of uveitis
Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi‐Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. S., & Handa, J. T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.033 · Cited by 79 · see citing works
Tumour necrosis factor α induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor κB and activator protein-1
Yang, H., Magilnick, N., Ou, X., & Lu, S. C.-L. (2005) · Biochemical Journal · doi:10.1042/bj20050795 · Cited by 79 · see citing works
β-Phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages
Rose, P. E., Won, Y.-K., Ong, C. N., et al. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.03.001 · Cited by 78 · see citing works
Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins
Leonardo, C. C., & Doré, S. (2011) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000013 · Cited by 77 · see citing works
Ellagic acid protects Lipopolysaccharide/d-galactosamine-induced acute hepatic injury in mice
Gu, L., Deng, W.-S., Liu, Y., Jiang, C., Sun, L.-C., Sun, X., Xu, Q., & Zhou, H. Y. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.07.005 · Cited by 75 · see citing works
MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation
Hwang, Y.-J., Lee, E., Song, J., Kim, H.-R., Jun, Y.-C., & Hwang, K. (2013) · Scientific Reports · doi:10.1038/srep03242 · Cited by 74 · see citing works
Thermo‐Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis: A 4‐Week Clinical Trial
Chava, V. K., & Vedula, B. D. (2012) · Journal of Periodontology · doi:10.1902/jop.2012.120425 · Cited by 74 · see citing works
Green tea extract provides extensive Nrf2‐independent protection against lipid accumulation and NFκB pro‐ inflammatory responses during nonalcoholic steatohepatitis in mice fed a high‐fat diet
Li, J., Sapper, T. N., Mah, E., Rudraiah, S., Schill, K. E., Chitchumroonchokchai, C., Moller, M. V., McDonald, J. D., Rohrer, P. R., Manautou, J. E., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500814 · Cited by 74 · see citing works
TIMP1 promotes multi-walled carbon nanotube-induced lung fibrosis by stimulating fibroblast activation and proliferation
Dong, J., & Ma, Q. (2016) · Nanotoxicology · doi:10.1080/17435390.2016.1262919 · Cited by 74 · see citing works
Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB
Lee, S.-H., Choi, S.-Y., Choo, Y.-Y., Kim, O., Trần, P. T., Dao, C. T., Min, B.-S., & Lee, J. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.06.015 · Cited by 73 · see citing works
The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCδ/Nrf2/ARE signaling to up-regulation of heme oxygenase-1
Kim, B.-C., Jeon, W.-K., Hong, H.-Y., Jeon, K. B., Hahn, J.-H., Kim, Y., Numazawa, S., Yosida, T., Park, E., & Lim, C. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.05.032 · Cited by 73 · see citing works
The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2
Plafker, K. S., Nguyen, L., Barneche, M., Mirza, S., Crawford, D., & Plafker, S. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121913 · Cited by 72 · see citing works
SINGLE BOLUS INJECTION OF BILIRUBIN IMPROVES THE CLINICAL OUTCOME IN A MOUSE MODEL OF ENDOTOXEMIA
Kadl, A., Pontiller, J., Exner, M., et al. (2007) · Shock · doi:10.1097/shk.0b013e31804d41dd · Cited by 69 · see citing works
Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner
Tao, S., Rojo de la Vega, M., Quijada, H., Wondrak, G. T., Wang, T., Garcia, J. G. N., & Zhang, D. D. (2016) · Scientific Reports · doi:10.1038/srep18760 · Cited by 68 · see citing works
A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis
Rastegarpanah, M., Malekzadeh, R., Vahedi, H., et al. (2012) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-012-1026-x · Cited by 67 · see citing works
Artesunate Protects Against Sepsis-Induced Lung Injury Via Heme Oxygenase-1 Modulation
Cao, T., Jin, S., Fei, D., Kang, K., Jiang, L., Lian, Z.-Y., Pan, S., Zhao, M., & Zhao, M. (2015) · Inflammation · doi:10.1007/s10753-015-0290-2 · Cited by 66 · see citing works
Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2
Dong, J., & Ma, Q. (2015) · Nanotoxicology · doi:10.3109/17435390.2015.1110758 · Cited by 61 · see citing works
Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis
Yang, S., Chan, Y.-L., Hua, K., Chang, J., Chen, H., Tsai, Y.-J., Hsu, Y., Chao, L. K., Yang, F.-L., Tsai, Y., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.009 · Cited by 60 · see citing works
Understanding the role of NRF2-regulated miRNAs in human malignancies
Shah, N., Rushworth, S. A., Murray, M. Y., Bowles, K. M., & MacEwan, D. J. (2013) · Oncotarget · doi:10.18632/oncotarget.1181 · Cited by 60 · see citing works
Modulation of Nuclear Factor E2-related Factor-2 (Nrf2) Activation by the Stress Response Gene Immediate Early Response-3 (IER3) in Colonic Epithelial Cells
Stachel, I., Geismann, C., Aden, K., Deisinger, F., Rosenstiel, P. C., Schreiber, S., Sebens, S., Arlt, A., & Schäfer, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.490920 · Cited by 59 · see citing works
Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide
Kim, W., Kim, H.-U., Lee, H.-N., Kim, S. H., Kim, C., Cha, Y.-N., Joe, Y., Chung, H. T., Jang, J., Kim, K., et al. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5825 · Cited by 59 · see citing works
The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation
Choi, Y. H. (2016) · General Physiology and Biophysics · doi:10.4149/gpb_2015034 · Cited by 59 · see citing works
Diverse Nrf2 Activators Coordinated to Cobalt Carbonyls Induce Heme Oxygenase-1 and Release Carbon Monoxide in Vitro and in Vivo
Nikam, A. P., Ollivier, A., Rivard, M., Wilson, J. L., Mebarki, K., Martens, T., Dubois‐Randé, J., Motterlini, R., & Foresti, R. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01509 · Cited by 56 · see citing works
Fimasartan, a Novel Angiotensin-Receptor Blocker, Protects against Renal Inflammation and Fibrosis in Mice with Unilateral Ureteral Obstruction: the Possible Role of Nrf2
Kim, S., Kim, S. J., Yoon, H. E., Chung, S., Choi, B. S., Park, C. W., & Shin, S. J. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.13187 · Cited by 54 · see citing works
Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity
Lee, D., & Jeong, G. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.12.041 · Cited by 53 · see citing works
Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot randomized, comparative clinical trial
Yakoot, M., & Salem, A. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-32 · Cited by 52 · see citing works
CD36 Upregulation Mediated by Intranasal LV-NRF2 Treatment Mitigates Hypoxia-Induced Progression of Alzheimer's-Like Pathogenesis
Wang, C., Wang, Z., Xie, J., Cai, J., Wang, T., Xu, Y., Wang, X., & Li, A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5845 · Cited by 52 · see citing works
Self-citation
Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells
Yang, P., Wu, Z.-Z., Zhang, Y., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.05.006 · Cited by 47 · see citing works
rhTNFR:Fc increases Nrf2 expression via miR-27a mediation to protect myocardium against sepsis injury
Xue, W.-L., Bai, X., & Zhang, L. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.07.051 · Cited by 44 · see citing works
Effect of Broccoli Sprouts on Nasal Response to Live Attenuated Influenza Virus in Smokers: A Randomized, Double-Blind Study
Noah, T. L., Zhang, H., Zhou, H., Glista-Baker, E. E., Müller, L. L., Bauer, R. N., Meyer, M., Murphy, P. C., Jones, S., Letang, B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098671 · Cited by 44 · see citing works
A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways
Gan, F.-F., Ling, H. Y., Ang, X., Reddy, S. A., Lee, S. S.-H., Yang, H., Tan, S.-H., Hayes, J. D., Chui, W., & Chew, E. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.07.011 · Cited by 43 · see citing works
The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells
Ho, F., Kang, H.-C., Lee, S. T., et al. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.04.008 · Cited by 43 · see citing works
NALP3 inflammasome activation in protein misfolding diseases
Shi, F., Kouadir, M., & Yang, Y. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.05.011 · Cited by 42 · see citing works
Time course of clinical and neuroradiological effects of delayed‐release dimethyl fumarate in multiple sclerosis
Kappos, L., Giovannoni, G., Gold, R., Phillips, J. T., Arnold, D. L., Hotermans, C., Zhang, A., Viglietta, V., Fox, R. J., & the DEFINE and CONFIRM study investigators (2015) · European Journal of Neurology · doi:10.1111/ene.12624 · Cited by 40 · see citing works
Effectiveness of Topical Curcumin for Treatment of Mastitis in Breastfeeding Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Afshariani, R., Farhadi, P., Ghaffarpasand, F., & Roozbeh, J. (2014) · Oman Medical Journal · doi:10.5001/omj.2014.89 · Cited by 37 · see citing works
Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers
Reisman, S. A., Goldsberry, A., Lee, C. I., et al. (2015) · BMC Dermatology · doi:10.1186/s12895-015-0029-7 · Cited by 33 · see citing works
Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized, prospective study
Iwamura, H., Koie, T., Soma, O., et al. (2015) · BMC Urology · doi:10.1186/s12894-015-0115-5 · Cited by 27 · see citing works
A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes
Mirmiran, P., Bahadoran, Z., Golzarand, M., Zojaji, H., & Azizi, F. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-13-64 · Cited by 26 · see citing works
Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial
Bime, C., Wei, C. Y., Holbrook, J. T., et al. (2012) · Primary Care Respiratory Journal · doi:10.4104/pcrj.2012.00073 · Cited by 25 · see citing works
3 H-1,2-Dithiole-3-thione Targets Nuclear Factor κB to Block Expression of Inducible Nitric-Oxide Synthase, Prevents Hypotension, and Improves Survival in Endotoxemic Rats
Karuri, A. R., Huang, Y., Bodreddigari, S., Sutter, C. H., Roebuck, B. D., Kensler, T. W., & Sutter, T. R. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096396 · Cited by 21 · see citing works
Exacerbated autoimmune hepatitis successfully treated with leukocytapheresis and bilirubin adsorption therapy
Sawada, K., Ohnishi, K., Kosaka, T., et al. (1997) · Journal of Gastroenterology · doi:10.1007/bf02934123 · Cited by 18 · see citing works
Tert-butylhydroquinone protects the spinal cord against inflammatory response produced by spinal cord injury.
Jin, W., Ni, H., Hou, X., Ming, X., Wang, J., Yuan, B., Zhu, T., Jiang, J., Wang, H., & Liang, W. (2014) · PubMed · Cited by 18 · see citing works
The Nrf2 pathway as a potential therapeutic target for Huntington disease
Escartin, C., & Brouillet, E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.009 · Cited by 10 · see citing works
Correction: Effect of Broccoli Sprouts on Nasal Response to Live Attenuated Influenza Virus in Smokers: A Randomized, Double-Blind Study
Staff, T. P. O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109513 · Cited by 6 · see citing works
A Randomized, Double Blinded, Placebo-Controlled Clinical Trial of Silymarin in Ulcerative Colitis
Mansoor, Rastegarpanah, Reza, et al. (2015) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

The metabolic signature of macrophage responses
Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021 · see citing works
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works
Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
Arioz, B. I., Tastan, B., Tarakcioglu, E., Tufekci, K. U., Olcum, M., Ersoy, N., Bagriyanik, A., Genc, K., & Genc, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01511 · Cited by 516 · see citing works
Food as medicine: targeting the uraemic phenotype in chronic kidney disease
Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238 · see citing works
Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging
Karakaslar, E. O., Katiyar, N., Hasham, M., Youn, A., Sharma, S., Chung, C., Marches, R., Korstanje, R., Banchereau, J., & Ucar, D. (2023) · Aging Cell · doi:10.1111/acel.13792 · Cited by 98 · see citing works
Myricetin: Targeting signaling networks in cancer and its implication in chemotherapy
Javed, Z., Khan, K., Herrera-Bravo, J., Naeem, S., Iqbal, M. J., Raza, Q., Sadia, H., Raza, S., Bhinder, M., Calina, D., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02663-2 · Cited by 93 · see citing works
Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus
Mihaylova, V. T., Kong, Y., Fedorova, O., Sharma, L., Dela Cruz, C. S., Pyle, A. M., Iwasaki, A., & Foxman, E. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.033 · Cited by 59 · see citing works
Pre- and Early Post-treatment With Arthrospira platensis (Spirulina) Extract Impedes Lipopolysaccharide triggered Neuroinflammation in Microglia
Piovan, A., Battaglia, J., Filippini, R., Dalla Costa, V., Facci, L., Argentini, C., Pagetta, A., Giusti, P., & Zusso, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.724993 · Cited by 31 · see citing works
1,25-Dihydroxyvitamin D inhibits LPS-induced high-mobility group box 1 (HMGB1) secretion via targeting the NF-E2-Related factor 2-hemeoxygenase-1-HMGB1 pathway in macrophages
Rao, Z., Zhang, N., Xu, N., Pan, Y., Xiao, M., Wu, J., Zhou, H., Yang, S., & Chen, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01308 · Cited by 27 · see citing works
Nrf2 signaling pathway: focus on oxidative stress in osteoporosis
Gu, H.-Y., Liu, N., Lin, F.-X., & Yin, J. (2025) · Osteoporosis International · doi:10.1007/s00198-025-07592-0 · Cited by 10 · see citing works

The Nrf2-Keap1 signalling pathway: Mechanisms of ARE transcription regulation in antioxidant cellular defence
Atia, A., & Abdullah, A. (2014) · International Journal of PharmTech Research · Cited by 7 · see citing works
Keap1/Nrf2 Signaling Pathway
Sykiotis, G. P. (2021) · Antioxidants · doi:10.3390/antiox10060828 · Cited by 66 · see citing works
Oncogenic functions of the transcription factor Nrf2
Gañán‐Gómez, I., Wei, Y., Yang, H., Boyano-Adánez, M. C., & Garcia‐Manero, G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.041 · Cited by 200 · see citing works
Hormonal signaling and signal pathway crosstalk in the control of myometrial calcium dynamics
Sanborn, B. M. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.05.007 · Cited by 56 · see citing works
The visible human dataset: The anatomical platform for human simulation
Spitzer, V. M., & Whitlock, D. (1998) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199804)253:2 · Cited by 253 · see citing works

Authors: Ahmed, S. M. U., Luo, L., Namani, A., Wang, X. J., & Tang, X.
Affiliations: Zhejiang University (CN)
Nantong University (CN)
Corresponding author: Tang, Xiuwen
ORCID: Luo, Lin
Namani, Akhileshwar
Wang, Xiu Jun
Tang, Xiuwen
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2017-02
Volume: 1863
Issue: 2
Pages: 585-597
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2016.11.005
OpenAlex: W2548618596
Cited by: 1,794
References: 168
Citations by year: 2026: 127 · 2025: 193 · 2024: 225 · 2023: 237 · 2022: 269 · 2021: 289 · 2020: 222 · 2019: 127 · 2018: 67 · 2017: 33 · 2016: 1 · 2013: 1
FWCI: 6.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31571476, 81172230, 31370772, 31470752)
Natural Science Foundation of Zhejiang Province (LQ15C050001)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: Nrf2 signaling, Nrf2/Keap1 pathway, inflammation, antioxidant response element, anti-inflammatory phytochemicals, NLRP3 inflammasome, anti-inflammatory gene expression, inflammatory diseases, chronic disease, carcinogenesis
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Humans, Inflammation, Signal Transduction, NF-kappa B, NF-E2-Related Factor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nrf2 signaling pathway: pivotal roles in inflammation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks