Cited by 654Pancreatic function and diabetesEndoplasmic Reticulum Stress and DiseaseDiabetes Treatment and Management

The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus

Open access

Gerber, Philipp A., Rutter, Guy A.·2017·Antioxidants & Redox Signaling

DOI 10.1089/ars.2016.6755PMC PMC5372767

Open this paper in CoChat — free account Open PDF

Abstract

Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects ∼8% of the adult population worldwide. Pancreatic beta-cell dysfunction and loss are central to the disease process, although understanding of the underlying molecular mechanisms is still fragmentary. Recent Advances: Oversupply of nutrients, including glucose and fatty acids, and the subsequent overstimulation of beta cells, are believed to be an important contributor to insulin secretory failure in T2D. Hypoxia has also recently been implicated in beta-cell damage. Accumulating evidence points to a role for oxidative stress in both processes. Although the production of reactive oxygen species (ROS) results from enhanced mitochondrial respiration during stimulation with glucose and other fuels, the expression of antioxidant defense genes is unusually low (or disallowed) in beta cells. Critical Issues: Not all subjects with metabolic syndrome and hyperglycemia go on to develop full-blown diabetes, implying an important role in disease risk for gene–environment interactions. Possession of common risk alleles at the SLC30A8 locus, encoding the beta-cell granule zinc transporter ZnT8, may affect cytosolic Zn 2+ concentrations and thus susceptibility to hypoxia and oxidative stress. Future Directions: Loss of normal beta-cell function, rather than total mass, is increasingly considered to be the major driver for impaired insulin secretion in diabetes. Better understanding of the role of oxidative changes, its modulation by genes involved in disease risk, and effects on beta-cell identity may facilitate the development of new therapeutic strategies to this disease. Antioxid. Redox Signal . 26, 501–518.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1089/ars.2016.6755

Cites

219 of 219 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
Increased Prevalence of Sleep-Disordered Breathing in Adults
Peppard, P. E., Young, T., Barnet, J. H., Palta, M., Hagen, E. W., & Hla, K. M. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws342 · Cited by 4,618
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Emerging roles of caspase-3 in apoptosis
Porter, A. G., & Jänicke, R. U. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400476 · Cited by 3,921
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905

Show all 218 references

Research works printed but not linked: 2

10.1042/bj3520373 · DOI
Banting FG, and Best CH. The internal secretion of the pancreas. 1922. Indian J Med Res, 125: 251–266, 2007.

Sorted by citations

Items 501–600 of 646

Identification of Oxidative Stress-Related Biomarkers in Diabetic Kidney Disease
Ma, X., Zhang, X., Leng, T., Ma, J., Yuan, Z., Gu, Y., Hu, T., Liu, Q., & Shen, T. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1067504 · Cited by 2
Effectiveness of Hydroalcoholic Seed Extract of Securigera securidaca on Pancreatic Local Renin-Angiotensin System and Its Alternative Pathway in Streptozotocin-Induced Diabetic Animal Model
Khomari, F., Kiani, B., Alizadeh‐Fanalou, S., Babaei, M., Kalantari‐Hesari, A., Alipourfard, I., Mirzaei, F., Yarahmadi, S., & Bahreini, E. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/7285036 · Cited by 2
Paradigm of Insulin Resistance, Type 2 Diabetes, Obesity, Fatty Liver and Atherosclerosis in Metabolic Syndrome
Mitrea, A., Vladu, I. M., Rosu, M. M., Clenciu, D., Moța, E., & Moța, M. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1002510 · Cited by 2
Contributions of Mitochondrial Dysfunction to β Cell Failure in Diabetes Mellitus
Parnis, J., & Rutter, G. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00009-2 · Cited by 2
Self-citation
Serum Free Zinc as A Predictor for Excessive Function of Pancreatic Beta-Cells in Central-Obese Men
Rahman, M. N., Sukmawati, I. R., Puspitasari, I. M., & Fattah, M. (2019) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v11i3.618 · Cited by 2
High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cellsPreprint
Cuozzo, F., Viloria, K., Shilleh, A. H., Nasteska, D., Frazer-Morris, C., Jiao, Z., Boufersaoui, A., Marzullo, B. P., Smith, H., Bonner, C., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.21.521364 · Cited by 2
Self-citation
Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice
Albawardi, A. S., Saraswathiamma, D., Sharma, C., Elomami, A. S., Souid, A., & Almarzooqi, S. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021223 · Cited by 1
Effect of l-carnitine alone and in combination with metformin on the behavioral and biochemical alterations induced by streptozotocin in Wistar rats
Kaira, M., Walia, V., & Garg, M. (2024) · Nutrire · doi:10.1186/s41110-024-00268-5 · Cited by 1
Genome-Scale Metabolic Modeling of Human Pancreas with Focus on Type 2 Diabetes
Sertbaş, M., & Ülgen, K. Ö. (2025) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2024.0211 · Cited by 1
Reviving hope: unlocking pancreatic islet immortality by optimizing a trehalose-based cryopreservation media and cell-penetrating peptide
Samsonchi, Z., Amirian, R., Tayebi, L., Derakhshankhah, H., Izadi, Z., & Hajizadeh‐Saffar, E. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04168-x · Cited by 1
The contribution of dietary total antioxidant capacity to type 2 diabetes risk and levels of glycemic biomarkers: a systematic review
Kheirouri, S., & Alizadeh, H. (2025) · Osong Public Health and Research Perspectives · doi:10.24171/j.phrp.2024.0337 · Cited by 1
Miro1- a key player in β-cell function and mitochondrial dynamics under diabetes mellitus
Kavyashree, S., Harithpriya, K., & Ramkumar, K. M. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102039 · Cited by 1
Natural Products in Regulating Mitophagy for the Intervention of Atherosclerosis and Its Risk Factors: Mechanisms and Therapeutic Potential
Li, Y., Ma, H., Wang, Y., Zhang, S., Zhao, Y., & Liu, Z. (2025) · Phytotherapy Research · doi:10.1002/ptr.70041 · Cited by 1
The efficacy of saffron supplementation on inflammation and oxidative stress in patients with type-2 diabetes mellitus: a meta-analysis
Qin, L., Hu, N., Wang, K., & Chen, L. Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1634982 · Cited by 1
Salidroside improves hypoxia-induced milk synthesis disorder and endoplasmic reticulum stress via AKT/mTOR signaling in bovine mammary epithelial cells
Liu, Y., & Li, H. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120659 · Cited by 1
Procyanidin A2, a polyphenol autophagy-enhancer, ameliorates hyperglycemia through multifaceted insulin-related mechanisms
Song, B., Yoon, S. K., Lee, C. H., Alshammari, F. H., Yoo, C.-Y., Jeong, K.-S., Lee, D., & Lee, S.-H. (2025) · Scientific Reports · doi:10.1038/s41598-025-25111-3 · Cited by 2
Exploring plant-based metallic nanoparticles for advanced medicinal application in diabetes
Priya, Chaudhary, A., Rejeeth, C., Kumar, S., Ding, X., & Sharma, A. (2025) · Next Nanotechnology · doi:10.1016/j.nxnano.2025.100243 · Cited by 1
Antidiabetic Potential of Sea Urchin Tripneustes gratilla Nanosuspension Based on In Vitro Enzyme Inhibition, In Vivo Evaluation, and Chemical Profiling Approaches
Aljohani, A. K. B., Alharbi, A. S., Alhazmi, A. B., Hudhayri, M. N., Almuwallad, I. B., Alhazmi, M. A., Almohammadi, S. M., Alsaleh, A. I., Aldhafiri, A. J., Eltahir, H. M., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb48010008 · Cited by 1
Deregulated translation of the transcription factor Myt3 predisposes islet β cells to dysfunction under obesity-induced metabolic stress
Hu, R., Wang, Y., Yagan, M., Xu, Y., Simmons, A. J., Lau, K. S., Liu, Q., & Gu, G. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111164 · Cited by 1
ЗВ'ЯЗОК МІЖ ПОРАНЕННЯМИ ВІЙСЬКОВОСЛУЖБОВЦІВ ТА РОЗВИТКОМ ЦУКРОВОГО ДІАБЕТУ (ОГЛЯД ЛІТЕРАТУРИ)
Лурін, І., Місюра, К. В., Seliukova, N. Y., Tyzhnenko, T., Хорошун, Е., Макаров, В., & Nehoduiko, V. V. (2025) · PROBLEMS OF ENDOCRINE PATHOLOGY · doi:10.21856/j-pep.2025.4.06 · Cited by 1
Bone Marrow Mesenchymal Stromal Cells and Their Derived Extracellular Vesicles Protect Pancreatic Beta‐TC‐6 Cells From Hypoxia‐Induced Injury via miR‐539‐3p‐Mediated Downregulation of CD36 Expression
Lin, N., Liang, Y., Tang, M., Liu, F., Chen, L., Wu, L., Fu, Y., Li, Z., Zhu, L., & Chen, J. (2026) · Stem Cells International · doi:10.1155/sci/6616986 · Cited by 1
Oxygen and glucose supplementation increases rates of linear growth and cell proliferation in growth‐restricted fetal sheep
Varela, M., Chrisenberry, D. B., Johnson, E. H., Luna-Ramirez, R. I., Tracy, A. R., Kathuria, S., Zhao, W., Anderson, M. J., Brown, L. D., & Limesand, S. W. (2026) · The Journal of Physiology · doi:10.1113/jp290141 · Cited by 1
Mitochondria as Epigenetic Regulators of β-Cell Identity and Plasticity: A Metabolo-Epigenetic Perspective
Kim, Y. (2026) · Cells · doi:10.3390/cells15070595 · Cited by 2
Exendin-4 improves high glucose-induced mitochondrial dysfunction of pancreatic β-cells via PKA/Drp1 signaling
Zhao, J., Ling, X., Fan, S., Sun, Z., Huang, X., Fu, H., Liu, H., Xing, Y., & Zhu, X. (2026) · Journal of Endocrinology · doi:10.1530/joe-26-0023 · Cited by 1
Organelle proteomics of human, neonatal pig, healthy and diabetic mouse islets
Çalışkan, Ö. Ş., Haas, D. T., Ferreira, J. V., Chubanava, S., Kemter, E., Cota, P., Bastidas-Ponce, A., Tarquis-Medina, M., Czarnecki, O., Bhattacharya, S., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117751 · Cited by 1
Gymnemic acid protects murine pancreatic β‐cells by moderating hyperglycemic stress‐induced inflammation and apoptosis in type 1 diabetic rats
Kannan, P., Karthikeyan, P., Subramaniam, N., Mohan, T., Gopinath, B., Chakrapani, L. N., Shanthi, P., Raghunathan, M., & Kalaiselvi, P. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23050 · Cited by 1
Pathophysiology of Type 2 Diabetes: A General Overview of Glucose and Insulin Homeostasis
Ghasemi, A., & Kashfi, K. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815079814122010004 · Cited by 1
Free radical oxidation in the pathogenesis of metabolic syndrome
Александрович, А. Д., Демко, И. В., Solovyova, I. A., Sobko, E. A., Gordeeva, N. V., & Kraposhina, А. Y. (2022) · Russian Journal of Preventive Medicine · doi:10.17116/profmed20222511198 · Cited by 1
Protective effects of madecassoside, a triterpenoid from Centella asiatica , against oxidative stress in INS-1E cells
Tan, S. C., Rajendran, R., Bhattamisra, S. K., Krishnappa, P., Davamani, F. A., Chitra, E., Ambu, S. P., Furman, B. L., & Candasamy, M. (2024) · Natural Product Research · doi:10.1080/14786419.2024.2315499 · Cited by 2
Integrative Analyses of Mitophagy-Related Genes and Mechanisms Associated with Type 2 Diabetes in Muscle Tissue
Mao, W., Zong, G., Gao, Y., Qu, S., & Cheng, X. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46090619 · Cited by 1
Diabetes: a global challenge and the impact of melatonin
Rana, A., & Kushnir, О. Y. (2024) · Natural & Mathematical Sciences in Medicine and Medical Education · doi:10.24061/3083-5887.j.nmsmme.2024.1.i.1 · Cited by 1
Estimation of total antioxidant capacity in type 2 diabetic and normal healthy subjects
Jabeen, H., Zeeshan, M., Imran, M., Begum, S., Saleem, T., Ahmed, N., & Qasim, R. (2018) · INTERNATIONAL JOURNAL OF ENDORSING HEALTH SCIENCE RESEARCH (IJEHSR) · doi:10.29052/ijehsr.v6.i2.2018.22-29 · Cited by 1
Pancreatic islet isolation from donation after circulatory death pancreas
Doppenberg, J., Engelse, M., & de Koning, E. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814833-4.00040-x
Choosing Antithrombotic Therapy in Patients with Coronary Heart Disease and Type 2 Diabetes Mellitus: How to Reduce the Risk of Death
Koziolova, N. A., Karavaev, P. G., & Veklich, A. S. (2020) · Kardiologiia · doi:10.18087/cardio.2020.4.n1042 · Cited by 1
Joint Effects of Ethnic Enclave Residence and Air Pollution Exposure on Risk of Gestational Diabetes Mellitus Among Asian/Pacific Islander Women in the United States
Williams, A., Ha, S., Shenassa, E. D., Messer, L. C., Kanner, J., & Mendola, P. (2020) · Annals of Epidemiology · doi:10.1016/j.annepidem.2020.08.031 · Cited by 1
PARAMETERS OF OXIDATIVE HOMEOSTASIS IN CHILDREN WITH TYPE 1 DIABETES DEPENDING ON DURATION OF THE DISEASE AND COMPLICATIONS
Shevchenko, T. A., & Maidannyk, V. G. (2018) · Ukrainian Scientific Medical Youth Journal · doi:10.32345/usmyj.3(108).2018.11-16 · Cited by 1
[A Review of Progress of the Relation Between Stress Response and Diabetes Mellitus].
Yuan, K.-F., Shi, J.-Y., Peng, L.-Y., Li, C., & Zhang, Y. (2021) · 四川大学学报：医学版 · doi:10.12182/20210160103 · Cited by 1
Evaluation Effects of Quercetin on Streptozotocin-treated RINm5F Pancreatic β-cells in vitro
Mazraesefidi, M., Mohammad-Sadeghipour, M., Khorramdelazad, H., Mahmoodi, M., Khoshdel, A., Fahmidehkar, M., Hosseiniara, R., & Hajizadeh, M. R. (2021) · Current Chemical Biology · doi:10.2174/2212796816666211223101206 · Cited by 1
The Effect of Coenzyme Q10 on Oxidative Stress and Endoplasmic Reticulum Stress in an Experimental Diabetes Model
Toprak, M. S. (2023) · International Journal of Biochemistry & Physiology · doi:10.23880/ijbp-16000218
Effect of Clitoria ternatea L. Extract on Melatonin, NRF2, and MDA Levels in Diabetic RAT
Luciana, F., Damayanti, N. A., & Harliansyah (2023) · JURNAL KEDOKTERAN · doi:10.36679/kedokteran.v9i1.52 · Cited by 1
Nrf2 Regulates β-cell Mass by Suppressing Cell Death and Promoting ProliferationPreprint
Baumel-Alterzon, S., Katz, L. S., Brill, G., Jean-Pierre, C., Li, Y., Biswal, S. S., Garcı́a-Ocaña, A., & Scott, D. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.05.434145 · Cited by 1
Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast CellsPreprint
Kolaç, U. K., Dönmez, G., & Yalçın, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1706968/v1 · Cited by 1
Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic isletsPreprint
Liu, S., Wipf, I. J., Joglekar, A., Freshly, A., Bovee, C. E., Kim, L., Richtsmeier, S., Peachee, S. J., Kopriva, S., Vikram, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.17.624030 · Cited by 1
Reduction of Inflammatory Response by Way of Oxidative Stress with San Huang Decoction (SHD) In Perioperative Care: A Randomized Clinical Trial
Yao, C. (2017) · International Journal of Complementary & Alternative Medicine · doi:10.15406/ijcam.2017.07.00238
The effect of Indonesian herbal drink “Mbah Jayus” on hyperglycemic rats
Widyaningsih, T. D., Fanani, R., Siska, A. I., & Martati, E. (2019) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/230/1/012094
Novel nonapeptide GLP (28–36) amide derivatives with improved hypoglycemic and body weight lowering effects
Li, L., Wu, L., Xia, E., Yan, W., Cai, X., Han, J. D. J., & Sun, L. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.03.014
COMPARAÇÃO DO PADRÃO DE SAÚDE BUCAL ENTRE IDOSOS DIABÉTICOS E NÃO DIABÉTICOS DE UM MUNICÍPIO DO SUL DO BRASIL
Porcelli, I. C. D. S., Corsi, N. M., Barata, T. D. J. E., Moura, S. K., Cardelli, A. A. M., Poli‐Frederico, R. C., & Maciel, S. M. (2018) · Revista Uningá · doi:10.46311/2318-0579.55.euj2346
Caracterização do efeito imunomodulatório das células mesenquimais indiferenciadas na resposta inflamatória a Porphyromonas gingivalis
Misawa, M. Y. O. (2019) · doi:10.11606/t.23.2019.tde-08042019-164334
Efecto de ácidos grasos poliinsaturados y ácido nordihidroguaiarético sobre alteraciones pancreáticas en un modelo experimental de diabetes mellitus tipo 2
Díaz-Gerevini, G. T., Terceros, J., López, C. B., Poggio, L., Daín, A., & Repossi, G. (2019) · Alad · doi:10.24875/alad.19000372
Oxidative stress in alpha and beta cells as a selection criterion for biocompatible biomaterialsPreprint
Sthijns, M. M. J. P. E., Jetten, M. J. A., Mohammed, S. G., Claessen, S. M. H., de Vries, R. H. W., Stell, A. L., de Bont, D. F. A., Engelse, M. A., Mumcuoglu, D., van Blitterswijk, C., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/728683
Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
Marcantonio, D. D., & Sykes, S. M. (2019) · Journal of Visualized Experiments · doi:10.3791/59593
Comparing the protective effect of L-carnitine, chromium, and vitamin D with metformin on kidney parameters, lipid profiles, and antioxidant indices in streptozotocin-diabetic rats
Shahanipour, K., Tabatabaie, E., Noori, A., Samani, P. S., & Adibnejad, M. (2019) · Journal of Reports in Pharmaceutical Sciences · doi:10.4103/jrptps.jrptps_54_19
Vitamin D Supports b-Cell Remodeling Capacity and Could Reduce High Fat Diet-Induced Insulinitis in Pups Born to Diabetic Mothers
EL-DEEN, M. D. M. M. A. M. S., MARWA F. AMER, M. D. ;. G. N. M., & Abdallah, H. (2018) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2018.59867
¿Los protocolos experimentales son un símil real de la diabetes humana?
Moreno-Cortés, M. L., Gutiérrez‐García, A. G., & Contreras, C. M. (2020) · CienciaUAT · doi:10.29059/cienciauat.v14i2.1289
May C-peptide index be a new marker to predict proteinuria in anemic patients with type 2 diabetes mellitus?
Katipoğlu, B., Çomoǧlu, M., Ateş, İ., Yılmaz, N., & Berker, D. S. (2020) · Endocrine Regulations · doi:10.2478/enr-2020-0001
Posibilidades de la terapia antioxidante en diabetes mellitus tipo 2. Estudio del estrés oxidativo en una muestra poblacional de pacientes diabéticos
Nuñez-Musa, R. A., Sellés, A. J. N., Rossi, W. M., Marmolejos, R. G., Martı́nez-Sánchez, G., & Selman-Almonte, A. (2020) · Ciencia y Salud · doi:10.22206/cysa.2020.v4i3.pp71-93
The Roles of HIFs in the Complications of Diabetes
Yazıhan, N., & Kocak, M. K. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_8
Interference of altered plasma trace elements profile with hyperhomocysteinemia and oxidative stress damage to insulin secretion dysfunction in Psammomys obesus : focus on the selenium
Bouazza, A., Fontaine, E. M., Leverve, X. M., & Koceir, E.-A. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1839501 · Cited by 1
PHOENIX DACTYLIFERA FRUIT EXTRACT AMELIORATES ALTERED BIOCHEMICAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETES MELLITUS ALBINO RATS
O., O. A., ABAH, S. F., Inalegwu, B., & E., E. U. (2020) · International Journal of Current Pharmaceutical Research · doi:10.22159/ijcpr.2020v12i6.40275
Long-noncoding RNA NBR2 via targeting miR-19a-3p regulates pancreatic β cell function and provides novel biomarkers for type 2 diabetes mellitus
Wan, L., Song, X., & Zhu, B. (2021) · Archives of Medical Science · doi:10.5114/aoms/133746
Elevated Neuropeptide Y1 Receptor Signaling Contributes to β-cell Dysfunction and Failure in Type 2 DiabetesPreprint
Yang, C.-H., Onda, D. A., Lin, X., Fynch, S., Nadarajah, S., Pappas, E. G., Liu, X., Scott, J. W., Oakhill, J. S., Galić, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.14.444149
Higher NDUFS8 Serum Levels Correlate with Better Insulin Sensitivity in Type 1 DiabetesPreprint
Flotyńska, J., Klause, D., Kulecki, M., Cieluch, A., Pakuła, M., Zozulińska‐Ziółkiewicz, D., & Uruska, A. A. (2021) · Research Square · doi:10.21203/rs.3.rs-496330/v1
The decrease of histomorphometry and function of pancreas in male albino rats after induced by sleep deprivation
Arjadi, F., Gumilas, N. S. A., Harini, I. M., Samodro, P., & Andromeda, A. (2021) · Jurnal kedokteran dan kesehatan Indonesia · doi:10.20885/jkki.vol12.iss2.art3
Determination of the total content of flavonoids in herbal mixtures with anti-diabetic activity
Savych, A., Kryskiw, L., & Мосула, Л. М. (2021) · Farmatsevtychnyi zhurnal · doi:10.32352/0367-3057.5.21.08
Perfil inflamatório e caracterização de células peritoneais em modelo de pancreatite aguda
Serra, M. B. (2021) · doi:10.11606/t.5.2021.tde-09122021-135614
Diabetes Mellitus
Schürmann, A., & Joost, H. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_48
Vitamin D Supports (3-Cell Remodeling Capacity and Could Reduce High Fat Diet-induced Insulinitis in Pups Born to Diabetic Mothers
EL-DEEN, M. D. M. M. A. M. S., MARWA F. AMER, M. D. ;. G. N. M., & Abdallah, H. (2018) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2018.59611
Diabetes Mellitus
Schürmann, A., & Joost, H. (2021) · Springer eBooks · doi:10.1007/978-3-030-21573-6_48-1
Improvement of biochemical and hematological parameters in alloxan-induced diabetic rats via administration of ethanol extract of Garcinia kola seeds
Joshua, P. E., Enwelu, C. G., Obi, B. C., Asomadu, R. O., Ononiwu, C. P., Orhonigbe, I. O., & Alumanah, E. O. (2022) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-022-01094-z
Hypoxia causes pancreatic β-cell dysfunction by activating a transcriptional repressor BHLHE40Preprint
Tsuyama, T., Sato, Y., Yoshizawa, T., Matsuoka, T.-A., & Yamagata, K. (2022) · bioRxiv · doi:10.1101/2022.06.28.498031
Fallimento β-cellulare nel diabete mellito di tipo 1 e di tipo 2: esistono meccanismi comuni?
Marrano, N., Biondi, G., Giorgino, F., & Natalicchio, A. (2022) · il Diabete · doi:10.30682/ildia2202g
The Mediterranean diet biodiversity impact on metabolic and oxidative stress parameters in type 2 diabetes
RABHI, H., Guermouche, B., Merzouk, H., & Merzouk, S. A. (2022) · Genetics and Biodiversity Journal · doi:10.46325/gabj.v6i2.269
2 типті қант диабеті бар науқастарда эндотелиальды дисфункциямен байланысты тамырлы асқынулар
Duisenbek, A., Аблайханова, Н. Т., Қалдықараева, А. Т., Есенбекова, А. Е., Mukhitdin, B., Беркутовна, Е. З., & Кожамжарова, Л. С. (2022) · Bulletin of the Karaganda University “Biology medicine geography Series” · doi:10.31489/2022bmg3/176-184
WITHDRAWN: High-fat diet decreases anti-inflammatory activities due to the disturbance of hepatic lipid metabolism accompanied by intestinal microbiota and EGCG regulation in broilersPreprint
Dou, X., Cui, Y., Wu, J., Zhang, M., & Shan, A. (2023) · Research Square · doi:10.21203/rs.3.rs-2632236/v1
WITHDRAWN: High-fat diet decreases anti-inflammatory activities due to the disturbance of hepatic lipid metabolism accompanied by intestinal microbiota and EGCG regulation in broilersPreprint
(2023) · Research Square · doi:10.21203/rs.3.rs-2632236/v2
Features of carbohydrate metabolism disorders in acute pancreatitis
Николаевич, Щ. А., Morozov, S. V., Иванович, Л. А., Михайлович, М. В., Karpov, N. V., Mokhov, D. A., Levitskaya, A. N., Levitskaya, K. N., & Shalamova, S. V. (2023) · The Scientific Notes of the Pavlov University · doi:10.24884/1607-4181-2022-29-4-25-30
The study of the effect of biocanin A (a type of isoflavone) on serum levels of tumor necrosis factor alpha, interferon gamma and malondialdehyde and glutathione levels in pancreatic tissue of streptozotocin-induced diabetic rats
Taheri, F., & Salemi, Z. (2023) · Complementary Medicine Journal · doi:10.61186/cmja-13021
USO DE PLANTAS MEDICINAIS PARA O TRATAMENTO DO DECLÍNIO COGNITIVO INDUZIDO POR QUIMIOTERAPIA: UMA MINI-REVISÃO
Vasconcelos, Q. D. J. S., & Aragão, G. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-3
EFEITO DA METFORMINA NOS SINTOMAS COMPORTAMENTAIS DO TRANSTORNO DO ESPECTRO AUTISTA: UMA MINI REVISÃO
Freitas, M. C., & Aragão, G. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-1
ALTERAÇÕES VASCULARES EM MODELO DE SEPSE INDUZIDA POR LIGADURA E PERFURAÇÃO CECAL EM RATOS: UMA MINI REVISÃO
de Lima, F. S. P., Martins, A. B., de Queiroz, C. V. G., & Pires, A. D. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-6
ALTERAÇÕES SISTÊMICAS PROVOCADAS POR SEPSE INDUZIDA POR LIGADURA E PERFURAÇÃO CECAL EM RATOS: REVISÃO
Martins, A. B., de Lima, F. S. P., de Queiroz, C. V. G., & Pires, A. D. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-7
EFEITO DE SUBSTÂNCIAS BIOATIVAS OBTIDAS DE EXTRATOS DA PLANTA LIBIDIBIA FERREA NA CICATRIZAÇÃO DE FERIDAS CUTÂNEAS EM DIABÉTICOS: UMA MINI-REVIEW
de Lopes, M. R., Lima, I. C., & Assreuy, A. M. S. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-8
AVALIAÇÃO DO EFEITO ANTI-INFLAMATÓRIO DA PIPER LONGUM: REVISÃO NARRATIVA
de Morais, M. F., & Assreuy, A. M. S. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-5
PAPEL DA COENZIMA Q10 EM DOENÇAS DO SISTEMA NERVOSO CENTRAL: UMA MINI REVISÃO
Brito, I. C. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-4
ALTERAÇÕES NA REATIVIDADE MUSCULAR DE ARTÉRIA RENAL DE ANIMAIS COM NEFROPATIA DIABÉTICA E SEUS POSSÍVEIS ALVOS TERAPÊUTICOS: UMA REVISÃO DE LITERATURA
Lustosa, R. P., & Cardoso, J. H. L. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-11
USO E EFICÁCIA DO CANABIDIOL NO TRANSTORNO DO ESPECTRO AUTISTA
Pinheiro, A. S., & Aragão, G. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-2 · Cited by 1
UMA REVISÃO INTEGRATIVA DOS POTENCIAIS BENEFÍCIOS DA MATRICARIA CHAMOMILLA NAS COMPLICAÇÕES ASSOCIADAS AO DIABETES MELLITUS
dos Santos, A. N. C., da Silva, F. S. H., Vasconcelos, Y. D. A. G., & Coelho‐de‐Souza, A. N. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-10
O PAPEL DA CRONONUTRIÇÃO NA RESISTÊNCIA INSULÍNICA E GLICEMIA PÓS-PRANDIAL: MINI REVISÃO
da Silva, K. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-12
O MENTOL PROMOVE RELAXAMENTO DA MUSCULATURA LISA?
Feijó, C. A. R., & Aragão, G. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-13
VASORREATIVIDADE DA ARTÉRIA BASILAR DE RATOS DIABÉTICOS
Sandes, J. L. D. O., & Cardoso, J. H. L. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-9
Além da teoria: contribuições das ciências fisiológicas para a saúde
Aragão, G. F. (2023) · Amplla Editora eBooks · doi:10.51859/amplla.atc461.1123-0
Selecting Biocompatible Biomaterials for Stem Cell-Derived β-Cell Transplantation
de Vries, R. H. W., & van Apeldoorn, A. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_6
Considerations Pertaining to Implant Sites for Cell-Based Insulin Replacement Therapies
Marfil‐Garza, B. A., Cuesta‐Gomez, N., & Shapiro, A. M. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-41943-0_16 · Cited by 1
Oxidative stress prevention as an effective preventive strategy in type 2 diabetes mellitus
Bykov, Y. V. (2024) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202427031117
Enhancing Pancreatic B-Cell Viability and Longevity Through Novel Microencapsulation Strategies and Stromal Cell Support
Qin, T. (2024) · doi:10.33612/diss.979224131
Carica pubescens fruit juice improved superoxide dismutase, triglyceride and high-density lipoprotein levels in type 2 diabetes mellitus Wistar rats
Rachmawati, S. N., Kusuma, T. U., Anjani, G., & Muniroh, M. (2024) · Food Research · doi:10.26656/fr.2017.8(3).255
Renalase inhibition regulates β cell metabolism to defend against acute and chronic stressPreprint
MacDonald, T. L., Ryback, B. A., Pereira, J. A. D. S., Wei, S., Mendez, B., Cai, E. P., Ishikawa, Y., Weir, G. C., Bonner‐Weir, S., Kissler, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.11.598322
Crosstalk between the aryl hydrocarbon receptor and hypoxia inducible factor 1α pathways impairs downstream dioxin response in human islet modelsPreprint
Gang, N., van Allen, K. A., Willmore, W. G., Lynn, F. C., & Bruin, J. E. (2024) · bioRxiv · doi:10.1101/2024.09.25.615065
Strategies to Overcome Metabolic Syndrome and Related Diseases
(2025) · Frontiers research topics · doi:10.3389/978-2-8325-5556-9
Edible Mushroom Bioactive Compounds and Diabetes Management and Prevention
Adeyemo, R. O., Binuyo, M. O., Abolarinwa, T. O., Olubiyi, M. V., Lebeloane, M. M., Akinboye, A. O., Bale, M. I., Feyitimi, A.-R. A., Adebayo, I. A., & Akinola, S. A. (2025) · Reference series in phytochemistry · doi:10.1007/978-3-031-52642-8_27-1

Authors: Gerber, P. A., & Rutter, G. A.
Affiliations: University Hospital Zurich (CH)
Imperial College London (GB)
Corresponding author: Rutter, Guy A.
ORCID: Gerber, Philipp A.
Rutter, Guy A.
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2017-04
Volume: 26
Issue: 10
Pages: 501-518
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2016.6755
PMC: PMC5372767
OpenAlex: W2405977822
Cited by: 654
References: 218
Citations by year: 2026: 50 · 2025: 67 · 2024: 69 · 2023: 95 · 2022: 87 · 2021: 82 · 2020: 85 · 2019: 64 · 2018: 36 · 2017: 16
FWCI: 7.86
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Spiral (Imperial College London) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Wellcome Trust (FP7/2007–2013, WT098424AIA)
European Federation of Pharmaceutical Industries and Associations (FP7/20072013)
Diabetes UK (11/0004210)
European Commission (2007–2013, FP7 2007-2013, FP7/2007)
Universitätsspital Zürich
Innovative Medicines Initiative (FP7/2007‐2013, 155005)
Directorate for Biological Sciences
Medical Research Council (MR/K001981/1, MR/J0003042/1)
Biotechnology and Biological Sciences Research Council (BB/J015873/1)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: oxidative stress, hypoxia, beta-cell dysfunction, type 2 diabetes, insulin secretion, reactive oxygen species, mitochondrial respiration, antioxidant defense genes, metabolic syndrome, SLC30A8, zinc transporter 8, zinc, gene-environment interaction, beta-cell identity
MeSH terms: Animals, Hypoxia, Antioxidants, Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Islets of Langerhans, Mitochondria, Zinc, Islets of Langerhans Transplantation, Reactive Oxygen Species, Oxidative Stress, Lipid Metabolism, Insulin-Secreting Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks