Rutter, Guy A.

The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus

Gerber, P. A., & Rutter, G. A. (2017) · Antioxidants & Redox Signaling

Pancreatic function and diabetesEndoplasmic Reticulum Stress and Disease

Cited by 654

Beta cell hubs dictate pancreatic islet responses to glucose

Johnston, N. R., Mitchell, R. K., Haythorne, E., Pessoa, M. P., Semplici, F., Ferrer, J., Piemonti, L., Marchetti, P., Bugliani, M., Bosco, D., et al. (2016) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 454

Metformin Activates a Duodenal Ampk-Dependent Pathway to Lower Hepatic Glucose Production in Rats

Duca, F. A., Côté, C. D., Rasmussen, B. A., Zadeh-Tahmasebi, M., Rutter, G. A., Filippi, B. M., & Lam, T. K. T. (2015) · Nature Medicine

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 402

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

Lemaire, K., Ravier, M. A., Schraenen, A., Creemers, J. W. M., Van de Plas, R., Granvik, M., Van Lommel, L., Waelkens, E., Chimienti, F., Rutter, G. A., et al. (2009) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesTrace Elements in Health

Cited by 330

MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines*

Baroukh, N., Ravier, M. A., Loder, M. K., Hill, E. V., Bounacer, A., Scharfmann, R., Rutter, G. A., & Van Obberghen, E. (2007) · Journal of Biological Chemistry

Pancreatic function and diabetesMicroRNA in disease regulation

Cited by 326

Regulation of ATP production by mitochondrial Ca2+

Tarasov, A. I., Griffiths, E. J., & Rutter, G. A. (2012) · Cell Calcium

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 319

Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells

Ravier, M. A., & Rutter, G. A. (2005) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 264

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W.-H., Bugliani, M., Marchetti, P., et al. (2013) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 210

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

Tarasov, A. I., Semplici, F., Ravier, M. A., Bellomo, E. A., Pullen, T. J., Gilon, P., Sekler, I., Rizzuto, R., & Rutter, G. A. (2012) · PLoS ONE

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 174

Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic β-cells

Varadi, A., Ainscow, E. K., Allan, V. J., & Rutter, G. A. (2002) · Journal of Cell Science

Pancreatic function and diabetesCellular transport and secretion

Cited by 156

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

Hodson, D. J., Mitchell, R. K., Marselli, L., Pullen, T. J., Gimeno Brias, S., Semplici, F., Everett, K. L., Cooper, D. M. F., Bugliani, M., Marchetti, P., et al. (2014) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 147

The α-cell in diabetes mellitus

Gromada, J., Chabosseau, P., & Rutter, G. A. (2018) · Nature Reviews Endocrinology

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 143

Mechanisms of Weight Loss After Obesity Surgery

Akalestou, E., Miras, A. D., Rutter, G. A., & le Roux, C. W. (2022) · Endocrine Reviews

Bariatric Surgery and OutcomesRegulation of Appetite and Obesity

Cited by 136

SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome

Perez, Y., Shorer, Z., Liani-Leibson, K., Chabosseau, P., Kadir, R., Volodarsky, M., Halperin, D., Barber-Zucker, S., Shalev, H., Schreiber, R., et al. (2017) · Brain

Trace Elements in HealthNeurological diseases and metabolism

Cited by 99

Metformin Prevents Glucose-Induced Protein Kinase C-β2 Activation in Human Umbilical Vein Endothelial Cells Through an Antioxidant Mechanism

Gallo, A., Ceolotto, G., Pinton, P., Iori, E., Murphy, E., Rutter, G. A., Rizzuto, R., Semplicini, A., & Avogaro, A. (2005) · Diabetes

Metabolism, Diabetes, and CancerAdvanced Glycation End Products research

Cited by 95

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes

Metabolism, Diabetes, and CancerRegulation of Appetite and Obesity

Cited by 86

Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 β-cells

Varadi, A., Tsuboi, T., Johnson-Cadwell, L. I., Allan, V. J., & Rutter, G. A. (2003) · Biochemical and Biophysical Research Communications

Pancreatic function and diabetesCellular transport and secretion

Cited by 86

Frequency-dependent mitochondrial Ca2+ accumulation regulates ATP synthesis in pancreatic β cells

Tarasov, A. I., Semplici, F., Li, D., Rizzuto, R., Ravier, M. A., Gilon, P., & Rutter, G. A. (2013) · Pflügers Archiv - European Journal of Physiology

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 81

Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion

Fine, N. H. F., Doig, C. L., Elhassan, Y. S., Vierra, N. C., Marchetti, P., Bugliani, M., Nano, R., Piemonti, L., Rutter, G. A., Jacobson, D. A., et al. (2018) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 61

Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency

Mbaya, E., Oulès, B., Caspersen, C., Tacine, R., Massinet, H., Pennuto, M., Chrétien, D., Munnich, A., Rötig, A., Rizzuto, R., et al. (2010) · Cell Death & Differentiation

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 52

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes

Zheng, X., Ho, Q. W. C., Chua, M., Stelmashenko, O., Yeo, X. Y., Muralidharan, S., Torta, F., Chew, E. G. Y., Lian, M. M., Foo, J. N., et al. (2022) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesLipid metabolism and biosynthesis

Cited by 48

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Fang, Z., Chen, S., Pickford, P., Broichhagen, J., Hodson, D. J., Corrêa, I. R., Kumar, S., Görlitz, F., Dunsby, C., French, P. M. W., et al. (2020) · ACS Pharmacology & Translational Science

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 38

Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence

Carapeto, P., Iwasaki, K., Hela, F., Kahng, J., Alves-Wagner, A. B., Middelbeek, R. J. W., Hirshman, M. F., Rutter, G. A., Goodyear, L. J., & Aguayo-Mazzucato, C. (2024) · Nature Metabolism

Pancreatic function and diabetesTelomeres, Telomerase, and Senescence

Cited by 35

Effects on pancreatic Beta and other Islet cells of the glucose-dependent insulinotropic polypeptide

Khan, R., Tomas, A., & Rutter, G. A. (2020) · Peptides

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 24