The DOI matches its Crossref record; 308 of the 308 references it cites were found in a registry or an index.
The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease
Open accessAbstract
Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong oxidants, which kill bacteria and other invading pathogens. However, MPO also drives the development of numerous chronic inflammatory pathologies, including atherosclerosis, neurodegenerative disease, lung disease, arthritis, cancer, and kidney disease, which are globally responsible for significant patient mortality and morbidity. Recent Advances: The development of imaging approaches to precisely identify the localization of MPO and the molecular targets of HOCl in vivo is an important advance, as typically the involvement of MPO in inflammatory disease has been inferred by its presence, together with the detection of biomarkers of HOCl, in biological fluids or diseased tissues. This will provide valuable information in regard to the cell types responsible for releasing MPO in vivo , together with new insight into potential therapeutic opportunities. Critical Issues: Although there is little doubt as to the value of MPO inhibition as a protective strategy to mitigate tissue damage during chronic inflammation in experimental models, the impact of long-term inhibition of MPO as a therapeutic strategy for human disease remains uncertain, in light of the potential effects on innate immunity. Future Directions: The development of more targeted MPO inhibitors or a treatment regimen designed to reduce MPO-associated host tissue damage without compromising pathogen killing by the innate immune system is therefore an important future direction. Similarly, a partial MPO inhibition strategy may be sufficient to maintain adequate bacterial activity while decreasing the propagation of inflammatory pathologies.
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In the citing paper
“MPO converts hydrogen peroxide and chloride anions to hypochlorous acid and protects the organism against toxins and pathogens.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Davies and Hawkins 2020
In the citing paper
“Myeloperoxidase (MPO) is a heme-containing peroxidase released mainly by neutrophils (Davies and Hawkins 2020).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Davies and Hawkins 2020
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Citations
Cites
1 retracted
Myeloperoxidase Deletion Prevents High-Fat Diet–Induced Obesity and Insulin Resistance
Wang, Q., Xie, Z., Zhang, W., Zhou, J., Wu, Y., Zhang, M., Zhu, H., & Zou, M. (2014) · Diabetes · doi:10.2337/db14-0026 · Cited by 97
RetractedNovel cell death program leads to neutrophil extracellular traps
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Myeloperoxidase: friend and foe
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Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998) · Blood · doi:10.1182/blood.v92.9.3007.421k47_3007_3017 · Cited by 1,665
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
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Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
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- Hawkins CL, , Pattison DI, , Whiteman M, , and Davies MJ. Chlorination and nitration of DNA and nucleic acid components. In: Oxidative Damage to DNA, edited by Evans MD and Cooke MS. Austin, TX: Landes Bioscience and Springer Science, 2006, pp. 14–39.
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Cited by
Sorted by citations
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Oxidative Stress: Concept and Some Practical Aspects
Sies, H. (2020) · Antioxidants · doi:10.3390/antiox9090852 · Cited by 652
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries
Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani‐Cavalieri, I., Pôrto, L. C., & Valença, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 373
Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases
Albano, G. D., Gagliardo, R. P., Montalbano, A. M., & Profita, M. (2022) · Antioxidants · doi:10.3390/antiox11112237 · Cited by 284
The Roles of Neutrophil-Derived Myeloperoxidase (MPO) in Diseases: The New Progress
Lin, W. C., Chen, H., Chen, X., & Guo, C. (2024) · Antioxidants · doi:10.3390/antiox13010132 · Cited by 290
Metadata
- Authors
- Davies, M. J., & Hawkins, C. L.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Hawkins, Clare L.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2020-03-24
- Volume
- 32
- Issue
- 13
- Pages
- 957-981
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W3003715287
- Cited by
- 332
- References
- 306
- Citations by year
- 2026: 46 · 2025: 56 · 2024: 61 · 2023: 64 · 2022: 54 · 2021: 33 · 2020: 17
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Novo Nordisk Fonden (NNF17OC0028990, NNF13OC0004294)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- myeloperoxidase, hypochlorous acid, biomolecule modification, chronic inflammation, innate immunity, MPO inhibitors, atherosclerosis, neurodegenerative diseases, lung disease, arthritis, cancer, kidney disease, host tissue damage, bacterial killing
- MeSH terms
- Animals, Arthritis, Enzyme Inhibitors, Humans, Hypochlorous Acid, Inflammation, Kidney Diseases, Lung Diseases, Peroxidase, Neoplasms, Neurodegenerative Diseases, Atherosclerosis
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