The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
On the Complexity of Multiple Sequence Alignment
Abstract
We study the computational complexity of two popular problems in multiple sequence alignment: multiple alignment with SP-score and multiple tree alignment. It is shown that the first problem is NP-complete and the second is MAX SNP-hard. The complexity of tree alignment with a given phylogeny is also considered.
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Citations
Cites
Optimization, approximation, and complexity classes
Papadimitriou, C. H., & Yannakakis, M. (1991) · Journal of Computer and System Sciences · doi:10.1016/0022-0000(91)90023-x · Cited by 1,653
Cited by
MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662
LAGAN and Multi-LAGAN: Efficient tools for large-scale multiple alignment of genomic DNA
Brudno, M., Do, C. B., Cooper, G. M., Kim, M. F., Davydov, E., Program, N. C. S., Green, E. D., Sidow, A., & Batzoglou, S. (2003) · Genome Research · doi:10.1101/gr.926603 · Cited by 1,115
GRANT, T., FROST, D. R., CALDWELL, J. P., GAGLIARDO, R., HADDAD, C. F. B., KOK, P. J. R., MEANS, D. B., NOONAN, B. P., SCHARGEL, W. E., & WHEELER, W. C. (2006) · Bulletin of the American Museum of Natural History · doi:10.1206/0003-0090(2006)299[1:psodfa]2.0.co;2 · Cited by 578
Multiple protein structure alignment at scale with FoldMason
Gilchrist, C. L. M., Mirdita, M., & Steinegger, M. (2026) · Science · doi:10.1126/science.ads6733 · Cited by 117
Biology and medicine in the landscape of quantum advantages
Cordier, B. A., Sawaya, N. P. D., Guerreschi, G. G., & McWeeney, S. K. (2022) · Journal of The Royal Society Interface · doi:10.1098/rsif.2022.0541 · Cited by 87
Metadata
- Authors
- WANG, L., & JIANG, T.
- Venue
- Journal of Computational Biology
- Publisher
- SAGE Publications
- Published
- 1994-01
- Volume
- 1
- Issue
- 4
- Pages
- 337-348
- ISSN
- 1066-5277 (ISSN-L)
- 1557-8666
- OpenAlex
- W2002638840
- Cited by
- 934
- References
- 1
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- WANG, L., & JIANG, T. (1994). On the Complexity of Multiple Sequence Alignment. Journal of Computational Biology. https://doi.org/10.1089/cmb.1994.1.337
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
