Impact of environmental temperature on skin thickness and microvascular blood flow in subjects with and without diabetes
Abstract
Background Glucose measurement from different skin areas might be influenced by changes in skin texture due to several environmental confounders. Our study was performed to investigate the effect of changes in ambient temperature on skin thickness and microvascular skin blood flow in subjects with and without diabetes at the lower forearm. Methods Thirteen subjects with diabetes and seven without diabetes participated in the study. The investigations were performed in a temperature- and humidity-controlled climatic chamber (EMPA, St. Gallen, Switzerland). Starting at 25 degrees C, the environmental temperature was changed in 4 degrees C steps every 40 min. Skin thickness was measured by an ultrasonic reflection technique, and microcirculation was measured by laser Doppler fluxmetry at the lower forearm. Study participants underwent the entire procedure on up to four separate study trials. Results Our study revealed a significantly reduced skin thickness (P Conclusions Although skin thickness and microvascular skin blood flow at the lower forearm were found to be reduced in patients with diabetes compared with controls without diabetes, both groups revealed comparable dynamics in skin thickness and microvascular blood flow during changes in environmental temperature.
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More subcutaneous fat and thicker skin produce a higher skin blood flow rate.
“In addition, it has been reported that more subcutaneous fat and thicker skin produced a higher skin blood flow rate (Fost et al., 2006; Petrofsky, McLellan, Bains, Prowse, Ethiraju, Lee, Gunda, S, Lohman, Schwab, 2008a; Petrofsky, Suh, Gunda, Prowse, & Batt, 2008b).”
From A two-node mechanistic thermophysiological model for pigs reared in hot climates – Part 1: Physiological responses and model development (2021) · cites this paper as Fost et al., 2006
Cites
Ellison, J. M., Stegmann, J. M., Colner, S. L., Michael, R. H., Sharma, M. K., Ervin, K. R., & Horwitz, D. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.6.961 · Cited by 133 · see citing works
Jungheim, K., & Koschinsky, T. (2002) · Diabetes Care · doi:10.2337/diacare.25.6.956 · Cited by 114 · see citing works
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Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone
Shokrekhodaei, M., & Quinones, S. (2020) · Sensors · doi:10.3390/s20051251 · Cited by 221 · see citing works
Caduff, A., Dewarrat, F., Talary, M., Stalder, G., Heinemann, L., & Feldman, Y. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2006.01.031 · Cited by 155 · see citing works
Self-citationIn vivo life sign application of dielectric spectroscopy and non-invasive glucose monitoring
Talary, M. S., Dewarrat, F., Huber, D., & Caduff, A. (2007) · Journal of Non-Crystalline Solids · doi:10.1016/j.jnoncrysol.2007.03.038 · Cited by 50 · see citing works
Self-citationHuang, T., Rong, L., Zhang, G., Brandt, P., Bjerg, B., Pedersen, P., & Granath, S. W. Y. (2021) · Biosystems Engineering · doi:10.1016/j.biosystemseng.2021.08.024 · Cited by 13 · see citing works
- Authors
- Forst, T., Caduff, A., Talary, M., Weder, M., Brändle, M., Kann, P., Flacke, F., Friedrich, C., & Pfützner, A.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Solianis, Zurich, Switzerland.
- Empa (CH)
- Kantonsspital St. Gallen (CH)
- Philipps University of Marburg (DE)
- Venue
- Diabetes Technology & Therapeutics
- Publisher
- SAGE Publications
- Published
- 2006-02
- Volume
- 8
- Issue
- 1
- Pages
- 94-101
- ISSN
- 1520-9156 (ISSN-L)
- 1557-8593
- OpenAlex
- W1979252227
- Cited by
- 51
- References
- 2
- Citations by year
- 2025: 1 · 2024: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 5 · 2015: 3 · 2014: 5 · 2013: 1
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Technology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Keywords
- skin thickness, microvascular blood flow, diabetes mellitus, ambient temperature, skin microcirculation, skin texture, laser Doppler flowmetry
- MeSH terms
- Adult, Blood Flow Velocity, Diabetes Mellitus, Female, Humans, Male, Microcirculation, Microclimate, Middle Aged, Reference Values, Skin, Temperature, Ultrasonography, Laser-Doppler Flowmetry
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