The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Detection of Altered Global DNA Methylation in Coronary Artery Disease Patients
Abstract
Epigenetic modifications, especially alteration in DNA methylation, are increasingly being recognized as a key factor in the pathogenesis of complex disorders, including atherosclerosis. However, there are limited data on the epigenetic changes in the coronary artery disease (CAD) patients. In the present study we evaluated the methylation status of genomic DNA from peripheral lymphocytes in a cohort of 287 individuals: 137 angiographically confirmed CAD patients and 150 controls. The differential susceptibility of genomic DNA to methylation-sensitive restriction enzymes was utilized to assess the methylation status of the genome. We observed that the genomic DNA methylation in CAD patients is significantly higher than in controls (p < 0.05). Since elevated homocysteine levels are known to be an independent risk factor for CAD and a key modulator of macromolecular methylation, we investigated the probable correlation between plasma homocysteine levels and global DNA methylation. We observed a significant positive correlation of global DNA methylation with plasma homocysteine levels in CAD patients (p = 0.001). Further, within a higher range of serum homocysteine levels (>/=12-50 muM), global DNA methylation was significantly higher in CAD patients than in controls. The alteration in genomic DNA methylation associated with cardiovascular disease per se appears to be further accentuated by higher homocysteine levels.
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Cites
Prediction of coronary heart disease using risk factor categories
Wilson, P. W. F., D’Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., & Kannel, W. B. (1998) · Circulation · doi:10.1161/01.cir.97.18.1837 · Cited by 9,581
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · cited 1×
“…significantly reduce the risk of adverse events in cardiovascular disease patients although the levels of homocysteine were substantially reduced (Bonaa et al. , 2006; Lonn et al. , 2006), thus questioning the role of level of vitamin B12 = B6 in preventing adverse effects of homocysteine in CAD.”
Epigenetics and aging: the targets and the marks
Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · cited 2×
“Aging is known to cause global DNA hypomethylation and promoter hypermethylation (Fraga and Esteller, 2007).”
Lund, A. H., & van Lohuizen, M. (2004) · Genes & Development · doi:10.1101/gad.1232504 · Cited by 489
Methyl CpG-binding proteins and transcriptional repression
Wade, P. A. (2001) · BioEssays · doi:10.1002/bies.10008 · Cited by 351
Cited by
Functional Genomics of the 9p21.3 Locus for Atherosclerosis: Clarity or Confusion?
Chen, H.-H., Almontashiri, N. A. M., Antoine, D., & Stewart, A. F. R. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0502-7 · Cited by 45
Metadata
- Authors
- Sharma, P., Kumar, J., Garg, G., Kumar, A., Patowary, A., Karthikeyan, G., Ramakrishnan, L., Brahmachari, V., & Sengupta, S.
- Venue
- DNA and Cell Biology
- Publisher
- SAGE Publications
- Published
- 2008-07
- Volume
- 27
- Issue
- 7
- Pages
- 357-365
- ISSN
- 1044-5498 (ISSN-L)
- 1557-7430
- OpenAlex
- W1989231052
- Cited by
- 206
- References
- 6
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sharma, P., Kumar, J., Garg, G., Kumar, A., Patowary, A., Karthikeyan, G., Ramakrishnan, L., Brahmachari, V., & Sengupta, S. (2008). Detection of Altered Global DNA Methylation in Coronary Artery Disease Patients. DNA and Cell Biology. https://doi.org/10.1089/dna.2007.0694
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