Soy Isoflavones, CYP1A1 , CYP1B1 , and COMT Polymorphisms, and Breast Cancer: A Case–Control Study in Southwestern China
Abstract
CYP1A1, CYP1B1, and COMT are key enzymes involved in estrogen metabolism. Soy isoflavones, phytoestrogens found in soy foods, may modify the activity of these enzymes. A case-control study was conducted to assess the associations between soy isoflavone intake and the CYP1A1 Ile462Val, CYP1B1 Val432Leu, and COMT Val158Met polymorphisms and breast cancer, as well as their combined effects on breast cancer. A total of 400 newly diagnosed breast cancer cases and 400 healthy controls were recruited. Participants' daily intake of soy isoflavones (DISI [mg/day]) was calculated and transformed to energy-adjusted DISI by the residual method. Gene sequencing was used to analyze CYP1A1, CYP1B1, and COMT polymorphisms. Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were estimated by conditional logistic regression. A strong protective dose-dependent effect of energy-adjusted DISI on breast cancer was found in both pre- and postmenopausal women (P(trend) 1, OR 95% CIs exclude 1). In premenopausal women, only carrying CYP1B1 Leu/Leu was associated with breast cancer risk (aOR = 2.05, 95% CI: 1.11-3.79). Carrying CYP1A1 Val/Val was related to breast cancer risk only among all women. A stratified analysis was performed at two levels of energy-adjusted DISI, with wildtype homozygous genotypes and low energy-adjusted DISI as the reference. In the high energy-adjusted DISI subgroup, carrying the CYP1B1 Leu/Leu genotype did not affect breast cancer risk in either all women or…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Eight of 12 (67%) studies examining high soy food or protein and six of seven (86%) studies examining high soy isoflavones reported inverse associations between soy and breast cancer risk.
“Eight of 12 (67%) studies examining high soy food or protein [45,46,61,64,72,77,78,81] and six of seven (86%) studies examining high soy isoflavones [42,43,45,75,77,81] reported inverse associations between soy and breast cancer risk.”
From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [43]
Of 44 case-control studies, 32 showed higher consumption of soy foods and/or soy isoflavones was associated with lower risk for primary breast cancer, breast cancer mortality, or improved markers of prognosis among the overall study population.
“Overall, of the 44 case control studies, 32 showed that higher consumption of soy foods and/ or soy isoflavones was associated with lower risk for primary breast cancer [42-46,49-51,53,54,56-58,61-64,66,71-73,75,77-79,81,83], breast cancer mortality [55], or improved markers of prognosis (ER+ status vs receptor negative status) [74,82] among the overall study population.”
From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [43]
Among case-control studies reporting odds ratios with confidence intervals, nine of 16 (56%) showed a significant inverse relationship between soy isoflavone intake and breast cancer risk.
“Of the 16 studies, nine (56%) showed a significant inverse relationship between soy isoflavone intake and risk of breast cancer [42,43,45,48,49,63,75,77,81].”
From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [43]
Cited by
Sorted by citations
Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review
Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D., Cooley, K., Wong, R., Sagar, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081968 · Cited by 188 · see citing works
- Authors
- Wang, Q., Li, H., Tao, P., Wang, Y.-P., Yuan, P., Yang, C.-X., Li, J.-Y., Yang, F., Lee, H., & Huang, Y.
- Affiliations
- Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
- Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, P.R. China.
- Chengdu Center for Disease Control and Prevention (CN)
- Venue
- DNA and Cell Biology
- Publisher
- SAGE Publications
- Published
- 2011-08
- Volume
- 30
- Issue
- 8
- Pages
- 585-595
- ISSN
- 1044-5498 (ISSN-L)
- 1557-7430
- OpenAlex
- W2040389541
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 5
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- DNA and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- soy isoflavones, phytoestrogens, breast cancer risk, COMT Val158Met polymorphism, estrogen metabolism, gene-diet interaction, dose-dependent effects, postmenopausal women, premenopausal women, Han Chinese
- MeSH terms
- Adult, Aged, Aryl Hydrocarbon Hydroxylases, Breast Neoplasms, Catechol O-Methyltransferase, China, Diet, Energy Metabolism, Female, Humans, Isoflavones, Middle Aged, Polymorphism, Genetic, Risk Factors, Glycine max, Case-Control Studies, Cytochrome P-450 CYP1A1, Genetic Predisposition to Disease, Asian People, Cytochrome P-450 CYP1B1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
