Caffeine increases sweating sensitivity via changes in sudomotor activity during physical loading
Abstract
We assessed the effect of caffeine on sudomotor activity and sweating sensitivity during physical loading. Both physiological responses could occur due to energy expenditure. Subjects were 13 athletically trained males (22.1 ± 3.7 years old, 174.2 ± 5.4 cm tall, and weighing 70.9 ± 4.6 kg, with maximal oxygen consumption [VO(2)max] of 53.6 ± 4.4 mL/kg/minute). The study involved a within-subject, random, crossover design. Tests were performed following the ingestion of 3 mg/kg caffeine. The physical loading involved running for 30 minutes at 60% VO(2)max (24.0 ± 0.5°C, 40 ± 3.0% relative humidity). Tympanic temperature (TYMP) was significantly higher in the caffeine-consuming group (Caffe-I) at pre-exercise (40 minutes after caffeine intake and immediately before running) (P<.05). Mean body temperature (mT(b)) was significantly higher in the Caffe-I group at pre- and post-exercise (30 min after start of running) (P<.05). Onset time of localized sweating was significantly shorter in the Caffe-I group (P<.01), but localized sweat volume and active sweat gland output (per single gland) was significantly higher in the Caffe-I group (P<.001). Activated sweat gland density was significantly increased in the Caffe-I group on the abdomen and thigh (P<.01). In conclusion, caffeine ingestion caused not only increases in TYMP and mT(b) through thermogenesis, but also an increased sweating sensitivity via changes in sudomotor activity.
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In a study of nonhabitual caffeine consumers, mean body temperature was significantly higher before and after exercise following caffeine consumption than following water consumption.
“Mean body temperature (calculated from tympanic and skin temperatures) was significantly higher in pre-(by 0.08 C) and post exercise (by 0.14 C) following caffeine consumption than following water consumption”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Kim et al., 2011
In a study of nonhabitual caffeine consumers, after caffeine consumption, sweating rate was significantly higher and the onset of sweating was significantly delayed during exercise.
“After caffeine consumption, sweating rate was significantly higher and the onset of sweating was significantly delayed during exercise.”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Kim et al., 2011
In a study of nonhabitual caffeine consumers, tympanic body temperature increased significantly pre-exercise only following caffeine consumption.
“whereas tympanic body temperature increased significantly pre-exercise only (by 0.12 C).”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Kim et al., 2011
Cites
A new weighting system for mean surface temperature of the human body
Ramanathan, N. (1964) · Journal of Applied Physiology · doi:10.1152/jappl.1964.19.3.531 · Cited by 1,892 · see citing works
Endurance running and the evolution of Homo
Bramble, D. M., & Lieberman, D. E. (2004) · Nature · doi:10.1038/nature03052 · Cited by 1,748 · see citing works
Textbook of Medical Physiology
Andreiss, I. A. P., Banfíƈ, H., Barac-Latas, V., Crljen, V., Čulo, F., Ćuk, M., Dujić, Ž., Đogaš, Z., Grčević, D., Kučić, N., et al. (2006) · Cited by 1,654 · see citing works
Caffeine and Exercise: Metabolism, Endurance and Performance
Graham, T. E. (2001) · Sports Medicine · doi:10.2165/00007256-200131110-00002 · Cited by 819 · see citing works
Metabolic, Catecholamine, and Exercise Performance Responses to Various Doses of Caffeine
Graham, T. E., & Spriet, L. L. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.867 · Cited by 488 · see citing works
Mechanisms of thermal acclimation to exercise and heat.
NADEL, E. R., PANDOLF, K. B., Roberts, M. F., & Stolwijk, J. A. (1974) · Journal of Applied Physiology · doi:10.1152/jappl.1974.37.4.515 · Cited by 425 · see citing works
Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., & Madsen, J. (1990) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.5.759 · Cited by 309 · see citing works
Acheson, K. J., Zahorska‐Markiewicz, B., Pittet, P., Anantharaman, K., & Jéquier, E. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.5.989 · Cited by 307 · see citing works
Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A. L., & Miller, D. S. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.1.44 · Cited by 258 · see citing works
Metabolic Effects of Caffeine in Humans: Lipid Oxidation or Futile Cycling?
Acheson, K. J., Gremaud, G., Meirim, I., Montigon, F., Krebs, Y., Fay, L. B., Gay, L.-J., Schneiter, P., Schindler, C., & Tappy, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.1.40 · Cited by 239 · see citing works
Carter, A. J., O'Connor, W. T., Carter, M. J., & Ungerstedt, U. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09521-7 · Cited by 132 · see citing works
Human thermoregulation: separating thermal and nonthermal effects on heat loss
Glen, P. K. (2009) · Frontiers in bioscience · doi:10.2741/3620 · Cited by 122 · see citing works
Dulloo, A. G., Seydoux, J., & Girardier, L. (1992) · Metabolism · doi:10.1016/0026-0495(92)90015-3 · Cited by 114 · see citing works
The Impact of heat exposure and repeated exercise on circulating stress hormones
Brenner, I., Zamecnik, J., Shek, P. N., & Shephard, R. J. (1997) · European Journal of Applied Physiology · doi:10.1007/s004210050274 · Cited by 109 · see citing works
Enhanced metabolic response to caffeine in exercise-trained human subjects
LEBLANC, J., Jobin, M., Cote, J., Samson, P., & Labrie, A. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.3.832 · Cited by 85 · see citing works
Endurance exercise with and without a thermal clamp: effects on leukocytes and leukocyte subsets
Cross, M. C., Radomski, M. W., Vanhelder, W. P., Rhind, S. G., & Shephard, R. J. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.2.822 · Cited by 77 · see citing works
Caffeine and Cognition in Functional Magnetic Resonance Imaging
Koppelstaetter, F., Poeppel, T. D., Siedentopf, C., Ischebeck, A. K., Kolbitsch, C., Mottaghy, F. M., Felber, S. R., Jaschke, W. R., & Krause, B. J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1417 · Cited by 69 · see citing works
Effects of intravenous caffeine administered to healthy males during sleep
Lin, A. S., Uhde, T. W., Slate, S. O., & McCann, U. D. (1997) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1997)5:1 · Cited by 59 · see citing works
Lee, J., Bae, J.-S., Matsumoto, T., Yang, H., & Min, Y. (2008) · International Journal of Biometeorology · doi:10.1007/s00484-008-0197-9 · Cited by 53 · see citing works
Self-citationMETABOLIC AND HORMONAL RESPONSES TO EXOGENOUS HYPERTHERMIA IN MAN
Møller, N., BECKWITH, R., Butler, P. C., Christensen, N. J., Ørskov, H., & Alberti, K. G. M. M. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb00271.x · Cited by 49 · see citing works
Prolonged residence of temperate natives in the tropics produces a suppression of sweating
Bae, J.-S., Lee, J., Matsumoto, T., Othman, T., Min, Y., & Yang, H. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0098-x · Cited by 41 · see citing works
Self-citationCharacterization of muscarinic receptor subtype of rat eccrine sweat gland by autoradiography
Torres, N. E., Zollman, P. J., & Low, P. A. (1991) · Brain Research · doi:10.1016/0006-8993(91)90415-r · Cited by 36 · see citing works
Human Growth Hormone Secretion During Exposure to Hot Air in Normal Adult Male Subjects
Okada, Y., Matsuoka, T., & Kumahara, Y. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-5-759 · Cited by 29 · see citing works
Lee, J.-B., Kim, T., Shin, Y.-O., Min, Y.-K., & Yang, H. (2010) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2010.14.5.273 · Cited by 24 · see citing works
Self-citationThe change in peripheral sweating mechanisms of the tropical Malaysian who stays in Japan
Lee, J., Bae, J.-S., Lee, M., Yang, H., Min, Y., Song, H., Ko, K.-K., Kwon, J., & Matsumoto, T. (2004) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2004.08.049 · Cited by 21 · see citing works
Self-citationLong-Term Tropical Residency Diminishes Central Sudomotor Sensitivities in Male Subjects
Lee, J. B., Bae, J. S., Shin, Y. O., Kang, J. C., Matsumoto, T., Toktasynovna, A. A., ALIPOV, G. K., Kim, W.-J., Min, Y. K., & Yang, H. M. (2007) · Korean Journal of Physiology and Pharmacology · Cited by 21 · see citing works
Self-citationStrong Heat Exposure and Adenohypophyseal Hormone Secretion in Man
Leppäluoto, J., Ranta, T., Laisi, U., Partanen, J., Virkkunen, P. J., & Lybeck, H. (1975) · Hormone and Metabolic Research · doi:10.1055/s-0028-1095672 · Cited by 20 · see citing works
Children in sauna: hormonal adjustments to intensive short thermal stress
Jokinen, E. V., Välimäki, I., Marniemi, J., Seppänen, A., Irjala, K. M. A., & Simell, O. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09178.x · Cited by 20 · see citing works
Thermoregulatory effects of purines and caffeine
Wager-Srdar, S. A., Oken, M. M., Morley, J. E., & Levine, A. S. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90637-9 · Cited by 18 · see citing works
Lee, J. (2008) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2008.12.6.349 · Cited by 18 · see citing works
Self-citationKim, T.-W., Shin, Y., Lee, J., Min, Y., & Yang, H. (2010) · Food Science and Biotechnology · doi:10.1007/s10068-010-0151-6 · Cited by 17 · see citing works
Self-citationPlasma Aldosterone, Prolactin and ACTH: Relationships in Man during Heat Exposure
FOLLENIUS, M., BRANDENBERGER, G., Simeoni, M., & Reinhardt, B. (1979) · Hormone and Metabolic Research · doi:10.1055/s-0028-1095768 · Cited by 13 · see citing works
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Cited by
Sorted by citations
A Review of Caffeine’s Effects on Cognitive, Physical and Occupational Performance
McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.001 · Cited by 840 · see citing works
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613 · see citing works
“In a double-blind randomised cross-over study (Kim et al., 2011), 13 male students who were nonhabitual caffeine consumers, who followed daily aerobic training, completed two experimental trials (i.”
MethodEffect of caffeine on cycling time-trial performance in the heat
Pitchford, N. W., Fell, J. W., LEVERITT, M. D., Desbrow, B., & Shing, C. M. (2013) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2013.07.004 · Cited by 38 · see citing works
Beaumont, R. E., & James, L. J. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.03.017 · Cited by 29 · see citing works
Hunt, L. A., Hospers, L., Smallcombe, J. W., Mavros, Y., & Jay, O. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00172.2021 · Cited by 24 · see citing works
Lee, J., Kim, T.-W., Min, Y., & Yang, H. (2015) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2015.19.1.9 · Cited by 22 · see citing works
Self-citationFilip-Stachnik, A., Krzysztofik, M., Coso, J. D., & Wilk, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194380 · Cited by 20 · see citing works
Akbar, M., Wandy, A., Soraya, G. V., Goysal, Y., Lotisna, M., & Basri, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18184 · Cited by 23 · see citing works
Low caffeine dose improves intermittent sprint performance in hot and humid environments
Nakamura, D., Tanabe, Y., Arimitsu, T., Hasegawa, H., & Takahashi, H. (2020) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2020.102698 · Cited by 14 · see citing works
The Effects of Caffeine Ingestion Before Passive Heat Loading on Serum Leptin Levels in Humans
Kim, T.-W., & Lee, J. (2013) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-013-0296-x · Cited by 12 · see citing works
Self-citationJohn, K., Kathuria, S., Peel, J., Page, J., Aitkenhead, R., Felstead, A., Heffernan, S. M., Jeffries, O., Tallent, J., & Waldron, M. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05460-z · Cited by 11 · see citing works
Tinsley, G. M., Urbina, S. L., Mullins, J., Outlaw, J. J., Hayward, S. E., Stone, M., Foster, C. A., Wilborn, C., & Taylor, L. W. (2017) · Europe PMC (PubMed Central) · Cited by 10 · see citing works
Lee, J., & Kim, T.-W. (2019) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1938236.118 · Cited by 10 · see citing works
Self-citationPassive heat loading links lipolysis and regulation of fibroblast growth factor-21 in humans
Lee, J., & Kim, T.-W. (2014) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2014.09.004 · Cited by 10 · see citing works
Self-citationSeasonal acclimation in sudomotor function evaluated by QSART in healthy humans
Shin, Y. O., Lee, J., & Kim, J. (2016) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2016.20.5.499 · Cited by 10 · see citing works
Self-citationKazman, J. B., Attipoe, S., Kupchak, B. R., & Deuster, P. A. (2020) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2020.102563 · Cited by 9 · see citing works
Effects of caffeine ingestion and thermotherapy on blood orexin circulation in humans
Park, T.-H., Lee, H.-J., Kwon, R.-W., Lee, I.-H., Lee, S., Park, J.-I., Choo, E.-A., & Lee, J. (2022) · Food Science and Biotechnology · doi:10.1007/s10068-022-01094-z · Cited by 8 · see citing works
Self-citationBeneficial effect of Oligonol supplementation on sweating response under heat stress in humans
Lee, J. B., & Shin, Y. O. (2014) · Food & Function · doi:10.1039/c4fo00521j · Cited by 5 · see citing works
Self-citationCoffee intake may promote sudomotor function activation via the contribution of caffeine
Kwon, R.-W., Park, J., Lee, H.-G., Park, J.-I., Choo, E.-A., Lee, S., & Lee, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1051828 · Cited by 4 · see citing works
Self-citationLee, J., Shin, Y., & Murota, H. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3184 · Cited by 2 · see citing works
Self-citationImproved sweat gland function during active heating in tennis athletes
Lee, J., Na, S.-B., & Kim, T.-W. (2015) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2015.04.008 · Cited by 2 · see citing works
Self-citationLee, H., Park, T.-H., Yun, B., Lee, I.-H., Moon, M., Kim, S., Lim, Y.-R., Kim, M., Bae, D.-J., Kim, J. K., et al. (2025) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-25-00003
Self-citationGlas, B., Stachurska, M., Dunford, L. J., & Shayesteh, A. (2025) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s547497
- Authors
- Kim, T.-W., Shin, Y.-O., Lee, J.-B., Min, Y.-K., & Yang, H.-M.
- Affiliations
- Soonchunhyang University (KR)
- Corresponding author
- Lee, Jeong-Beom
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2011-11
- Volume
- 14
- Issue
- 11
- Pages
- 1448-1455
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2112182693
- Cited by
- 23
- References
- 32
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- caffeine, sudomotor activity, thermoregulation, body temperature, thermogenesis, physical loading, physical activity, energy expenditure
- MeSH terms
- Adult, Body Temperature Regulation, Caffeine, Dose-Response Relationship, Drug, Energy Metabolism, Physical Exertion, Humans, Male, Motor Activity, Oxygen Consumption, Sweat Glands, Sweating, Cross-Over Studies, Young Adult
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