Beneficial Effects of a Combination of Curcuma longa L. and Citrus junos Against Beta-Amyloid Peptide-Induced Neurodegeneration in Mice
Open accessAbstract
Both Curcuma longa (CL) and Citrus junos Tanaka (CJ) have been used to treat various diseases due to their anti-inflammatory and antioxidative stress activities. In this study, we investigated the ameliorative effect of the combination of CL extract and CJ extract (CCC) against beta-amyloid (A β ) peptide-induced neurological damage. CCC prevented neurocytotoxicity in vitro . In addition, it was confirmed that abnormal alternation behavior and memory impairment caused by A β peptide were reversed by treatment with CCC. Furthermore, CCC treatment led to recovery of the cholinergic system and reactive oxygen species (ROS) oxidative damage defense system. CCC induced expressions of cyclic-adenosine monophosphate response element-binding protein (CREB)-responsive element-binding protein and brain-derived neurotrophic factor were confirmed as was the significantly improved processing in the hippocampus of the mouse A β peptides. Accordingly, these results suggest that CCC can prevent and/or reverse neurocytotoxicity and cognitive deficits in a mouse model of Alzheimer's disease.
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Curcumin in combination with Citrus junos ameliorates Aβ peptide-induced neurological damage.
“Recently, CL, in combination with Citrus junos, showed an ameliorative effect against Aβ peptide-induced neurological damage.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [77]
Combined extract of curcumin and Citrus junos reverses abnormal behavior and memory impairment caused by Aβ peptide and recovers cholinergic system and ROS defense.
“The combined extract was reported to reverse the abnormal behavior and memory impairment caused by Aβ peptide, leading to the recovery of the cholinergic system and ROS oxidative damage defense system [77].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [77]
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References 25 · Cited by 9
- Authors
- Kim, M. J., Park, S.-Y., Kim, Y., Jeon, S., Cha, M. S., Kim, Y. J., & Yoon, H.-G.
- Affiliations
- Yonsei University (KR)
- SDC Research and Development Center, Damyang-gun, Korea.
- Korea University (KR)
- Corresponding author
- Yoon, Ho-Geun
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2022-01
- Volume
- 25
- Issue
- 1
- Pages
- 33-39
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W4206344331
- Cited by
- 9
- References
- 25
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Keywords
- turmeric, Citrus junos, beta-amyloid peptide, Alzheimer's disease, neurodegeneration, neuroprotection, plant extract combination, memory impairment, cholinergic system, reactive oxygen species, oxidative stress, CREB, brain-derived neurotrophic factor, hippocampus, cognitive impairment
- MeSH terms
- Alzheimer Disease, Animals, Citrus, Disease Models, Animal, Peptide Fragments, Plant Extracts, Amyloid beta-Peptides, Curcuma, Mice
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