The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Contractile Physiology of Lymphatics
Open accessAbstract
The lymphatic system has important roles in body fluid regulation, macromolecular homeostasis, lipid absorption, and immune function. To accomplish these roles, lymphatics must move fluid and its other contents (macromolecules, lipids/chylomicra, immune cells) from the interstitium through the lymphatics, across the nodes, and into the great veins. Thus, the principal task of the lymphatic vascular system is transport. The body must impart energy to the lymph via pumping mechanisms to propel it along the lymphatic network and use pumps and valves to generate lymph flow and prevent its backflow. The lymphatic system utilizes both extrinsic pumps, which rely on the cyclical compression and expansion of lymphatics by surrounding tissue forces, and intrinsic pumps, which rely on the intrinsic rapid/phasic contractions of lymphatic muscle. The intrinsic lymph pump function can be modulated by neural, humoral, and physical factors. Generally, increased lymph pressure/stretch of the muscular lymphatics activates the intrinsic lymph pump, while increased lymph flow/shear in the muscular lymphatics can either activate or inhibit the intrinsic lymph pump depending on the pattern and magnitude of the flow. To regulate lymph transport, lymphatic pumping and resistance must be controlled. A better understanding of these mechanisms could provide the basis for the development of better diagnostic and treatment modalities for lymphatic dysfunction.
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Cites
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Self-citationLymph Flow, Shear Stress, and Lymphocyte Velocity in Rat Mesenteric Prenodal Lymphatics
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Self-citationMutations in FOXC2 Are Strongly Associated With Primary Valve Failure in Veins of the Lower Limb
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Self-citation
Cited by
Sabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet, M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.020 · Cited by 411
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Development and aging of the lymphatic vascular system
González-Loyola, A., & Petrova, T. V. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.005 · Cited by 89
Czepielewski, R. S., Erlich, E. C., Onufer, E. J., Young, S., Saunders, B. T., Han, Y.-H., Wohltmann, M., Wang, P. L., Kim, K.-W., Kumar, S., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.10.003 · Cited by 77
Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels
Zawieja, S. D., Castorena, J. A., Gui, P., Li, M., Bulley, S. A., Jaggar, J. H., Rock, J. R., & Davis, M. J. (2019) · Journal of General Physiology · doi:10.1085/jgp.201812294 · Cited by 70
Metadata
- Authors
- Zawieja, D. C.
- Venue
- Lymphatic Research and Biology
- Publisher
- SAGE Publications
- Published
- 2009-06
- Volume
- 7
- Issue
- 2
- Pages
- 87-96
- ISSN
- 1539-6851 (ISSN-L)
- 1557-8585
- OpenAlex
- W2048606411
- Cited by
- 368
- References
- 72
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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