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Cited by 10Lymphatic System and DiseasesImmune Response and InflammationLymphatic Disorders and Treatments

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Mesenteric Lymph Flow in Endotoxemic Guinea Pigs

Nemoto, Kayo, Sato, Hitoshi, Tanuma, Kumiko, Okamura, Tadao·2011·Lymphatic Research and Biology
DOI 10.1089/lrb.2011.0006
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Abstract

Background: Lipopolysaccharide (LPS) is a structural component of the outer membrane of gram-negative bacteria. LPS activates the host cells, leading to the production and release of proinflammatory cytokines. Given the induction duration for the release of cytokines, the initial mechanisms that produce LPS action on a timescale of minutes are not fully understood. We studied the effect of initial LPS-induced action on the lymphatic system by measuring the time-dependent changes in mesenteric lymph flow in guinea pigs in vivo . In addition, we determined the leakage of plasma protein into the lymphatic system using Evans blue dye. Methods and Results: The mesenteric lymphatic vessel was cannulated with a polyethylene catheter. We administered drugs via a catheter in jugular vein. The control animals received vehicle intravenously (i.v.). The experimental group received 1 mg/kg or 10 mg/kg LPS i.v. Twenty minutes before injection of the vehicle or LPS, Evans blue dye (5 mg/kg i.v.) was administered. Lymph output was measured every 20 min. The amount of Evans blue in the lymph was determined by spectrophotometry. The mesenteric lymph showed a steady flow rate of approximately 290 μL/kg/20 min. The lymph flow immediately increased after the administration of LPS and reached 3.4-fold and 7.4-fold after 1 h of 1 mg/kg and 10 mg/kg LPS injection, respectively. The albumin content in lymph significantly increased in proportion to the increased lymph volume. Conclusions: These results suggest that the early increase in mesenteric lymph flow rate in guinea pigs produced by LPS is mediated by vascular hyperpermeability and plasma albumin leakage.

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Crossref · 10.1089/lrb.2011.0006

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Research works printed but not linked: 3

  1. Ninomiya N, , Nemoto K, , Kaji M, , Shimada Y, , Yamamoto Y. Regulation of the endocannabinoid system in endotoxicosis of conscious guinea pigs. J Jap Assoc Acute Med, 2005; 16:218–226.
  2. Ohhashi T, , Azuma T, , Sakaguchi M. Active and passive mechanical characteristics of bovine mesenteric lymphatics. Am J Physiol, 1980; 239:H88–H95.
  3. Ninomiya N, , Nemoto K, , Okamura T, , Yamamoto Y. A novel experimental method for the study of intestinal paralysis due to endotoxicosis. J Jap Assoc Acute Med, 2003; 14:241–250.

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Metadata

Authors
Nemoto, K., Sato, H., Tanuma, K., & Okamura, T.
Affiliations
  • Nippon Medical School Hospital (JP)
  • Shinjuku Vocational College of Acupuncture and Judo Therapy
Corresponding author
Nemoto, Kayo
Venue
Lymphatic Research and Biology
Publisher
SAGE Publications
Published
2011-09-01
Volume
9
Issue
3
Pages
129-134
ISSN
  • 1539-6851 (ISSN-L)
  • 1557-8585
DOI
10.1089/lrb.2011.0006
OpenAlex
W1989769256
Cited by
10
References
17
Citations by year
2023: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1
FWCI
0.47
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Lymphatic Research and Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
Keywords
lipopolysaccharide, endotoxemia, plasma protein leakage, albumin, Evans blue, lymphatic vessels, inflammatory cytokines, gram-negative bacterial endotoxin
MeSH terms
Animals, Blood Pressure, Capillary Permeability, Disease Models, Animal, Evans Blue, Guinea Pigs, Lipopolysaccharides, Lymph, Male, Mesentery, Endotoxemia, Lymphatic Vessels

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