The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Mild Experimental Brain Injury in the Rat Induces Cognitive Deficits Associated with Regional Neuronal Loss in the Hippocampus
Abstract
Memory dysfunction following mild human traumatic brain injury (TBI) is a common clinical observation, but the pathologic substrate underlying this loss of function has not been well-characterized. In the present study, we examined the effects of a mild lateral fluid percussion (FP) brain injury on memory dysfunction, neuronal cell loss in specific regions of the hippocampus, and breakdown of the blood-brain barrier (BBB). A Morris Water Maze (MWM) memory paradigm was used to assess memory retention in rats 42 h after lateral FP brain injury (n = 11) or sham injury (n = 10). At the completion of cognitive testing, animals were sacrificed and neuronal cell loss in the hippocampi was examined with Nissl staining. Immunoreactivity to anti-rat IgG was used to evaluate the extent of BBB disruption. A significant correlation was observed between posttraumatic memory scores and neuronal loss in the hilus of the dentate gyrus (p < 0.005). To our knowledge, these observations are the first to suggest an association between cognitive deficits following a mild experimental brain injury and neuropathological changes in the hippocampus.
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Cites
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Self-citationA fluid percussion model of experimental brain injury in the rat
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Cited by
SMITH, D. H., SOARES, H. D., PIERCE, J. S., PERLMAN, K. G., SAATMAN, K. E., MEANEY, D. F., DIXON, C. E., & McINTOSH, T. K. (1995) · Journal of Neurotrauma · doi:10.1089/neu.1995.12.169 · Cited by 451
Self-citationProgressive atrophy and neuron death for one year following brain trauma in the rat
Smith, D. H., Chen, X.-H., Pierce, J. E. S., Wolf, J. A., Trojanowski, J. Q., Graham, D. I., & McIntosh, T. K. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.715 · Cited by 440
Self-citationPierce, J. E. S., Smith, D. H., Trojanowski, J. Q., & McIntosh, T. K. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00142-0 · Cited by 385
Self-citationSoares, H., Hicks, R., Smith, D., & McIntosh, T. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08223.1995 · Cited by 379
Self-citationExperimental models of traumatic brain injury: do we really need to build a better mousetrap?
Morales, D. M., Marklund, N., Lebold, D., Thompson, H. J., Pitkanen, A., Maxwell, W. L., Longhi, L., Laurer, H., Maegele, M., Neugebauer, E., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.030 · Cited by 339
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Metadata
- Authors
- HICKS, R. R., SMITH, D. H., LOWENSTEIN, D. H., MARIE, R. S., & McINTOSH, T. K.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 1993-01
- Volume
- 10
- Issue
- 4
- Pages
- 405-414
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2021218882
- Cited by
- 358
- References
- 38
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- HICKS, R. R., SMITH, D. H., LOWENSTEIN, D. H., MARIE, R. S., & McINTOSH, T. K. (1993). Mild Experimental Brain Injury in the Rat Induces Cognitive Deficits Associated with Regional Neuronal Loss in the Hippocampus. Journal of Neurotrauma. https://doi.org/10.1089/neu.1993.10.405
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