The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Overcoming Inhibition in the Damaged Spinal Cord
Abstract
Inhibition by several inhibitory molecules on oligodendrocytes, and by chondroitin sulphate proteoglycans and semaphorins in the glial scar discourages regeneration of axons in the injured spinal cord. This inhibition is compounded by the poor regenerative ability of most central nervous system (CNS) axons. Treatments that block some of these inhibitory mechanisms promote regeneration in animal models of cord injury. Plasticity is also reduced by some of the inhibitory molecules, and some of the treatments that promote regeneration also promote plasticity. This is probably a more achievable therapeutic target than axon regeneration, and an effective treatment would be of assistance to the majority of patients with partial cord injuries.
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Cites
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Self-citationReactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
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Self-citationSchnell, L., & Schwab, M. E. (1990) · Nature · doi:10.1038/343269a0 · Cited by 1,222
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
Bareyre, F. M., Kerschensteiner, M., Raineteau, O., Mettenleiter, T. C., Weinmann, O., & Schwab, M. E. (2004) · Nature Neuroscience · doi:10.1038/nn1195 · Cited by 1,086
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
Wang, K. C., Koprivica, V., Kim, J. A., Sivasankaran, R., Guo, Y., Neve, R. L., & He, Z. (2002) · Nature · doi:10.1038/nature00867 · Cited by 955
Schnell, L., Schneider, R., Kolbeck, R., Barde, Y.-A., & Schwab, M. E. (1994) · Nature · doi:10.1038/367170a0 · Cited by 909
Nogo-66 receptor antagonist peptide promotes axonal regeneration
GrandPré, T., Li, S., & Strittmatter, S. M. (2002) · Nature · doi:10.1038/417547a · Cited by 711
Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate
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Spinal Axon Regeneration Induced by Elevation of Cyclic AMP
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Cited by
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007
A Pericyte Origin of Spinal Cord Scar Tissue
Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O., & Frisén, J. (2011) · Science · doi:10.1126/science.1203165 · Cited by 858
Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets
Ng, S. Y., & Lee, A. Y. W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00528 · Cited by 852
The bright side of the glial scar in CNS repair
Rolls, A., Shechter, R., & Schwartz, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2591 · Cited by 674
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Meletis, K., Barnabé-Heider, F., Carlén, M., Evergren, E., Tomilin, N., Shupliakov, O., & Frisén, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060182 · Cited by 666
Metadata
- Authors
- Fawcett, J. W.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2006-04
- Volume
- 23
- Issue
- 3-4
- Pages
- 371-383
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W1982737759
- Cited by
- 279
- References
- 100
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
