Cited by 694Proteoglycans and glycosaminoglycans researchPolysaccharides and Plant Cell WallsGlycosylation and Glycoproteins Research

Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate

Sugahara, Kazuyuki, Mikami, Tadahisa, Uyama, Toru, Mizuguchi, Souhei, Nomura, Kazuya, Kitagawa, Hiroshi·2003·Current Opinion in Structural Biology

Abstract

Recent glycobiology studies have suggested fundamental biological functions for chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as glycosaminoglycan sidechains of proteoglycans in the extracellular matrix and at cell surfaces. They have been implicated in the signaling functions of various heparin-binding growth factors and chemokines, and play critical roles in the development of the central nervous system. They also function as receptors for various pathogens. These functions are closely associated with the sulfation patterns of the glycosaminoglycan chains. Surprisingly, nonsulfated chondroitin is indispensable in the morphogenesis and cell division of Caenorhabditis elegans, as revealed by RNA interference experiments of the recently cloned chondroitin synthase gene and by the analysis of mutants of squashed vulva genes.

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Crossref · 10.1016/j.sbi.2003.09.011

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Authors
Sugahara, K., Mikami, T., Uyama, T., Mizuguchi, S., Nomura, K., & Kitagawa, H.
Affiliations
  • Kobe Pharmaceutical University (JP)
  • Kyushu University (JP)
Corresponding author
Sugahara, Kazuyuki
Venue
Current Opinion in Structural Biology
Publisher
Elsevier BV
Published
2003-10
Volume
13
Issue
5
Pages
612-620
ISSN
0959-440X (ISSN-L)
OpenAlex
W2000460436
Cited by
694
References
65
Citations by year
2026: 9 · 2025: 21 · 2024: 14 · 2023: 27 · 2022: 35 · 2021: 41 · 2020: 35 · 2019: 20 · 2018: 24 · 2017: 32 · 2016: 32 · 2015: 39 · 2014: 34 · 2013: 36 · 2012: 38
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Structural Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Private School Promotion Foundation
  • Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Keywords
chondroitin sulfate, dermatan sulfate, chondroitin, glycosaminoglycans, proteoglycans, extracellular matrix, sulfation patterns, heparin-binding growth factors, chemokines, central nervous system development, pathogen receptors, Caenorhabditis elegans, cell division, morphogenesis
MeSH terms
Animals, Brain, Cell Division, Chondroitin Sulfates, Dermatan Sulfate, Growth Substances, Heparan Sulfate, Morphogenesis, Nerve Regeneration, Neurons, Structure-Activity Relationship, Signal Transduction, Neurites, Caenorhabditis elegans

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