CoChat
Sign Up
Cited by 124Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesLong-Term Effects of COVID-19

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Electrophysiology and Functional MRI in Post-Acute Mild Traumatic Brain Injury

Gosselin, Nadia, Bottari, Carolina, Chen, Jen-Kai, Petrides, Michael, Tinawi, Simon, de Guise, Élaine, Ptito, Alain·2011·Journal of Neurotrauma
DOI 10.1089/neu.2010.1493
Open this paper in CoChat — free account

Abstract

Symptoms persisting beyond the acute phase (>2 months) after a mild traumatic brain injury (MTBI) are often reported, but their origin remains controversial. Some investigators evoke dysfunctional cerebral mechanisms, while others ascribe them to the psychological consequences of the injury. We address this controversy by exploring possible cerebral dysfunction with functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) in a group of patients during the post-acute phase. Fourteen MTBI symptomatic patients (5.7±2.9 months post-injury) were tested with fMRI and ERP using a visual externally ordered working memory task, and were compared with 23 control subjects. Attenuated blood oxygen level dependent (BOLD) signal changes in the left and right mid-dorsolateral prefrontal cortex (mid-DLPFC), the putamen, the body of the caudate nucleus, and the right thalamus were found in the MTBI group compared with the control group. Moreover, symptom severity and BOLD signal changes were correlated: patients with more severe symptoms had lower BOLD signal changes in the right mid-DLPFC. For ERP, a group×task interaction was observed for N350 amplitude. A larger amplitude for the working memory task than for the control task was found in control subjects, but not in MTBI subjects, who had weak amplitudes for both tasks. This study confirms that persistent symptoms after MTBI cannot be uniquely explained by psychological factors, such as depression and/or malingering, and indicates that they can be associated with cerebral dysfunction. ERP reveals decreased amplitude of the N350 component, while fMRI demonstrates that the more severe the symptoms, the lower the BOLD signal changes in the mid-DLPFC.

Overview

Integrity signals

Registry

Crossref · 10.1089/neu.2010.1493

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 38 references

Research works printed but not linked: 4

  1. Beck A.T., 1996, Beck Depression Inventory: Manual
  2. Gosselin N., 2009, Tennet conferences
  3. Smits M., 2008, Hum. Brain Mapp
  4. Talairach J., 1988, Co-planar stereotactic atlas of the human brain

Cited by

Sorted by citations

Items 101–124 of 124

Related

See all

Metadata

Authors
Gosselin, N., Bottari, C., Chen, J.-K., Petrides, M., Tinawi, S., de Guise, É., & Ptito, A.
Affiliations
  • Montreal Neurological Institute and Hospital (CA)
  • University of Toronto (CA)
  • Montreal General Hospital (CA)
  • Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Corresponding author
Ptito, Alain
ORCID
Venue
Journal of Neurotrauma
Publisher
SAGE Publications
Published
2011-03
Volume
28
Issue
3
Pages
329-341
ISSN
  • 0897-7151 (ISSN-L)
  • 1557-9042
DOI
10.1089/neu.2010.1493
OpenAlex
W2053912118
Cited by
124
References
38
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 22 · 2016: 10 · 2015: 15 · 2014: 7 · 2013: 10 · 2012: 19
FWCI
9.12
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Neurotrauma (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Health Research Foundation
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Keywords
mild traumatic brain injury, post-concussion syndrome, dorsolateral prefrontal cortex, BOLD signal changes, event-related potentials, working memory, thalamus, caudate nucleus, putamen, symptom severity, brain dysfunction
MeSH terms
Adult, Analysis of Variance, Attention, Brain, Brain Injuries, Brain Mapping, Electroencephalography, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Reaction Time, Severity of Illness Index

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review