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Cited by 124Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesLong-Term Effects of COVID-19

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Electrophysiology and Functional MRI in Post-Acute Mild Traumatic Brain Injury

Gosselin, Nadia, Bottari, Carolina, Chen, Jen-Kai, Petrides, Michael, Tinawi, Simon, de Guise, Élaine, Ptito, Alain·2011·Journal of Neurotrauma
DOI 10.1089/neu.2010.1493
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Abstract

Symptoms persisting beyond the acute phase (>2 months) after a mild traumatic brain injury (MTBI) are often reported, but their origin remains controversial. Some investigators evoke dysfunctional cerebral mechanisms, while others ascribe them to the psychological consequences of the injury. We address this controversy by exploring possible cerebral dysfunction with functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) in a group of patients during the post-acute phase. Fourteen MTBI symptomatic patients (5.7±2.9 months post-injury) were tested with fMRI and ERP using a visual externally ordered working memory task, and were compared with 23 control subjects. Attenuated blood oxygen level dependent (BOLD) signal changes in the left and right mid-dorsolateral prefrontal cortex (mid-DLPFC), the putamen, the body of the caudate nucleus, and the right thalamus were found in the MTBI group compared with the control group. Moreover, symptom severity and BOLD signal changes were correlated: patients with more severe symptoms had lower BOLD signal changes in the right mid-DLPFC. For ERP, a group×task interaction was observed for N350 amplitude. A larger amplitude for the working memory task than for the control task was found in control subjects, but not in MTBI subjects, who had weak amplitudes for both tasks. This study confirms that persistent symptoms after MTBI cannot be uniquely explained by psychological factors, such as depression and/or malingering, and indicates that they can be associated with cerebral dysfunction. ERP reveals decreased amplitude of the N350 component, while fMRI demonstrates that the more severe the symptoms, the lower the BOLD signal changes in the mid-DLPFC.

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Research works printed but not linked: 4

  1. Beck A.T., 1996, Beck Depression Inventory: Manual
  2. Gosselin N., 2009, Tennet conferences
  3. Smits M., 2008, Hum. Brain Mapp
  4. Talairach J., 1988, Co-planar stereotactic atlas of the human brain

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Metadata

Authors
Gosselin, N., Bottari, C., Chen, J.-K., Petrides, M., Tinawi, S., de Guise, É., & Ptito, A.
Affiliations
  • Montreal Neurological Institute and Hospital (CA)
  • University of Toronto (CA)
  • Montreal General Hospital (CA)
  • Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Corresponding author
Ptito, Alain
ORCID
Venue
Journal of Neurotrauma
Publisher
SAGE Publications
Published
2011-03
Volume
28
Issue
3
Pages
329-341
ISSN
  • 0897-7151 (ISSN-L)
  • 1557-9042
DOI
10.1089/neu.2010.1493
OpenAlex
W2053912118
Cited by
124
References
38
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 22 · 2016: 10 · 2015: 15 · 2014: 7 · 2013: 10 · 2012: 19
FWCI
9.12
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Neurotrauma (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Health Research Foundation
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Keywords
mild traumatic brain injury, post-concussion syndrome, dorsolateral prefrontal cortex, BOLD signal changes, event-related potentials, working memory, thalamus, caudate nucleus, putamen, symptom severity, brain dysfunction
MeSH terms
Adult, Analysis of Variance, Attention, Brain, Brain Injuries, Brain Mapping, Electroencephalography, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Reaction Time, Severity of Illness Index

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