Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: An exploratory nutrigenomics study
Open accessAbstract
Virgin olive oil (VOO) is considered to be one of the main components responsible for the health benefits of the Mediterranean diet, particularly against atherosclerosis where peripheral blood mononuclear cells (PBMNCs) play a crucial role in atherosclerosis development and progression. The objective of this article was to identify the PBMNC genes that respond to VOO consumption in order to ascertain the molecular mechanisms underlying the beneficial action of VOO in the prevention of atherosclerosis. Gene expression profiles of PBMNCs from healthy individuals were examined in pooled RNA samples by microarrays after 3 weeks of moderate and regular consumption of VOO, as the main fat source in a diet controlled for antioxidant content. Gene expression was verified by qPCR. The response to VOO consumption was confirmed for individual samples (n = 10) by qPCR for 10 upregulated genes (ADAM17, ALDH1A1, BIRC1, ERCC5, LIAS, OGT, PPARBP, TNFSF10, USP48, and XRCC5). Their putative role in the molecular mechanisms involved in atherosclerosis development and progression is discussed, focusing on a possible relation with VOO consumption. Our data support the hypothesis that 3 weeks of nutritional intervention with VOO supplementation, at doses common in the Mediterranean diet, can alter the expression of genes related to atherosclerosis development and progression.
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In vitro and in vivo studies have described dramatic changes in transcription of genes and microRNAs involved in the pathophysiology of cardiometabolic diseases and cancer following EVOO interventions.
“As concerns possible mechanisms for a chemopreventive role of the MedDiet, several in vitro [174] and in vivo [175,176] studies have described dramatic changes in the transcription of genes and micro-RNAs involved in the pathophysiology of cardiometabolic diseases and cancer, following EVOO interventions.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [176]
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References 81 · Cited by 68
- Authors
- Khymenets, O., Fitó, M., Covas, M.-I., Farré, M., Pujadas, M.-A., Muñoz, D., Konstantinidou, V., & Torre, R. D. L.
- Affiliations
- Centro de Investigación Biomédica en Red (ES)
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Santiago de Compostela, Spain.
- Human Pharmacology and Clinical Neurosciences Research Group, Institut Municipal d'Investigació Mèdica (IMIM-Hospital del Mar), Barcelona, Spain.
- Municipal Institute for Medical Research (ES)
- Universitat Pompeu Fabra (ES)
- Venue
- OMICS A Journal of Integrative Biology
- Publisher
- SAGE Publications
- Published
- 2009-02
- Volume
- 13
- Issue
- 1
- Pages
- 7-19
- ISSN
- 1536-2310 (ISSN-L)
- 1557-8100
- OpenAlex
- W2050016837
- Cited by
- 68
- References
- 81
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 9 · 2012: 13
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- OMICS A Journal of Integrative Biology (publishedVersion)
- PubMed (publishedVersion)
- Hispana (publishedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, other-oa)
- Funders
- Centro Nacional de Investigaciones Cardiovasculares
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III (CP 06/00100)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- virgin olive oil, atherosclerosis, peripheral blood mononuclear cells, nutrigenomics, gene expression, Mediterranean diet, ADAM17, ALDH1A1, ERCC5, Lower Jurassic, O-GlcNAc transferase, TNFSF10, USP48, Ku80, dietary fat supplementation
- MeSH terms
- Olive Oil, Adult, Blood Glucose, Dietary Fats, Female, Humans, Leukocytes, Mononuclear, Lipids, Male, Plant Oils, Biomarkers, Dietary Supplements, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Diet, Mediterranean, Atherosclerosis, Nutrigenomics, Young Adult
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