Cited by 123Biochemical effects in animalsParkinson's Disease Mechanisms and TreatmentsCoenzyme Q10 studies and effects

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Carnisone Increases Efficiency of DOPA Therapy of Parkinson's Disease: A Pilot Study

Boldyrev, Alexander, Fedorova, Tatiana, Stepanova, Maria, Dobrotvorskaya, Irina, Kozlova, Eugenia, Boldanova, Natalia, Bagyeva, Gulbakhar, Ivanova-Smolenskaya, Irina, Illarioshkin, Serguey·2008·Rejuvenation Research

DOI 10.1089/rej.2008.0716

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Abstract

The addition of the neuropeptide carnosine ( β -alanyl-L-histidine) as a food additive to the basic protocol of Parkinson's disease treatment results in significant improvement of neurological symptoms, along with increase in red blood cell Cu/Zn-SOD and decrease in blood plasma protein carbonyls and lipid hydroperoxides, with no noticeable change in platelets MAO B activity. The combination of carnosine with basic therapy may be a useful way to increase efficiency of PD treatment.

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Authors: Boldyrev, A., Fedorova, T., Stepanova, M., Dobrotvorskaya, I., Kozlova, E., Boldanova, N., Bagyeva, G., Ivanova-Smolenskaya, I., & Illarioshkin, S.
Affiliations: Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
Research Center of Neurology (RU)
Russian Academy of Sciences (RU)
ORCID: Stepanova, Maria
Venue: Rejuvenation Research
Publisher: SAGE Publications
Published: 2008-08
Volume: 11
Issue: 4
Pages: 821-827
ISSN: 1094-5458 (ISSN-L)
1549-1684
1557-8577
DOI: 10.1089/rej.2008.0716
OpenAlex: W1978715967
Cited by: 123
References: 29
Citations by year: 2026: 2 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 14 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 4
FWCI: 2.03
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Rejuvenation Research (publishedVersion)
PubMed (publishedVersion)
Funders: Academy of Medical Sciences
Russian Academy of Sciences
Topics: Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Keywords: carnosine, Parkinson's disease, combination therapy, copper-zinc superoxide dismutase, protein carbonyls, lipid hydroperoxides, oxidative stress, neuroprotection
MeSH terms: Adult, Aged, Carnosine, Dihydroxyphenylalanine, Drug Synergism, Female, Humans, Male, Middle Aged, Monoamine Oxidase, Parkinson Disease, Pilot Projects, Superoxide Dismutase, Treatment Outcome, Oxidative Stress, Protein Carbonylation

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Carnisone Increases Efficiency of DOPA Therapy of Parkinson's Disease: A Pilot Study

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