Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d -Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway
Abstract
In this study, we evaluated the protective effects of naringenin on aging mice induced by d -galactose ( d -gal). Open field test and Morris water maze test were performed to evaluate the effect of naringenin on behavioral dysfunction. Hematoxylin-eosin staining, TUNEL staining, and Nissl staining were used to estimate the effect of naringenin on neurological deficits. Furthermore, naringenin markedly activated PI3K/Akt signaling, eventually promoted the nuclear translocation of nuclear factor-erythroid 2-related factor 2, and induced the expression of heme oxygenase 1 and NAD(P)H-quinone oxidoreductase 1. Superoxide dismutase (SOD), catalase (CAT), and thiobarbituric acid reactive substances (TBARS) assays were conducted to evaluate oxidative stress in d -gal-induced aging mice. Our finding demonstrated that naringenin was a promising agent for attenuating the aging process, and enhancing endogenous antioxidant defense capacity was a reliable strategy to delay the senescence process.
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In aging murine models, naringenin administration markedly stimulated Nrf2 activity and improved expression of antioxidant enzymes HO-1 and NADPH-quinone oxidoreductase 1, suggesting amelioration of behavioural and neurological dysfunctions.
“The authors reported that naringenin administration markedly stimulated the activity of Nrf2 and improved the expression of the antioxidant enzymes HO-1 and NADPH-quinone oxidoreductase 1 [301].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [301]
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- Authors
- Zhang, Y., Liu, B., Chen, X., Zhang, N., Li, G., Zhang, L.-H., & Tan, L.-Y.
- Affiliations
- Heilongjiang University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- The First Affiliated Hospital of Jiamusi University
- Corresponding author
- Chen, Xi
- Venue
- Rejuvenation Research
- Publisher
- SAGE Publications
- Published
- 2017-12
- Volume
- 20
- Issue
- 6
- Pages
- 462-472
- ISSN
- 1094-5458 (ISSN-L)
- 1549-1684
- 1557-8577
- OpenAlex
- W2626719895
- Cited by
- 57
- References
- 41
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 3 · 2017: 1
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Rejuvenation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Keywords
- naringenin, D-galactose-induced aging, aging, neuroprotection, behavioral dysfunction, neurological deficit, PI3K/Akt signaling, Nrf2 nuclear translocation, heme oxygenase-1, NQO1, oxidative stress, antioxidant defense, senescence, flavonoids
- MeSH terms
- Aging, Animals, Behavior, Animal, Body Weight, Brain, Disease Models, Animal, Galactose, Male, Memory, Mice, Inbred ICR, Motor Activity, Neurons, Organ Size, Oxidation-Reduction, Signal Transduction, Apoptosis, Oxidative Stress, Phosphatidylinositol 3-Kinases, Flavanones, Proto-Oncogene Proteins c-akt, NF-E2-Related Factor 2, Spatial Learning
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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