Cited by 57Antioxidants, Aging, Portulaca oleraceaPhytochemicals and Antioxidant ActivitiesFlavonoids in Medical Research

Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d -Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway

Zhang, Yan, Liu, Bin, Chen, Xi, Zhang, Ning, Li, Guang, Zhang, Li-Hong, Tan, Li-Yan·2017·Rejuvenation Research

Abstract

In this study, we evaluated the protective effects of naringenin on aging mice induced by d -galactose ( d -gal). Open field test and Morris water maze test were performed to evaluate the effect of naringenin on behavioral dysfunction. Hematoxylin-eosin staining, TUNEL staining, and Nissl staining were used to estimate the effect of naringenin on neurological deficits. Furthermore, naringenin markedly activated PI3K/Akt signaling, eventually promoted the nuclear translocation of nuclear factor-erythroid 2-related factor 2, and induced the expression of heme oxygenase 1 and NAD(P)H-quinone oxidoreductase 1. Superoxide dismutase (SOD), catalase (CAT), and thiobarbituric acid reactive substances (TBARS) assays were conducted to evaluate oxidative stress in d -gal-induced aging mice. Our finding demonstrated that naringenin was a promising agent for attenuating the aging process, and enhancing endogenous antioxidant defense capacity was a reliable strategy to delay the senescence process.

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Crossref · 10.1089/rej.2017.1960

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  • In aging murine models, naringenin administration markedly stimulated Nrf2 activity and improved expression of antioxidant enzymes HO-1 and NADPH-quinone oxidoreductase 1, suggesting amelioration of behavioural and neurological dysfunctions.

    “The authors reported that naringenin administration markedly stimulated the activity of Nrf2 and improved the expression of the antioxidant enzymes HO-1 and NADPH-quinone oxidoreductase 1 [301].”

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Authors
Zhang, Y., Liu, B., Chen, X., Zhang, N., Li, G., Zhang, L.-H., & Tan, L.-Y.
Affiliations
  • Heilongjiang University of Chinese Medicine (CN)
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • The First Affiliated Hospital of Jiamusi University
Corresponding author
Chen, Xi
Venue
Rejuvenation Research
Published
2017-12
Volume
20
Issue
6
Pages
462-472
ISSN
  • 1094-5458 (ISSN-L)
  • 1549-1684
  • 1557-8577
OpenAlex
W2626719895
Cited by
57
References
41
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 3 · 2017: 1
FWCI
2.94
Type
journal article
Language
en
Open access
closed
Locations
  • Rejuvenation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Keywords
naringenin, D-galactose-induced aging, aging, neuroprotection, behavioral dysfunction, neurological deficit, PI3K/Akt signaling, Nrf2 nuclear translocation, heme oxygenase-1, NQO1, oxidative stress, antioxidant defense, senescence, flavonoids
MeSH terms
Aging, Animals, Behavior, Animal, Body Weight, Brain, Disease Models, Animal, Galactose, Male, Memory, Mice, Inbred ICR, Motor Activity, Neurons, Organ Size, Oxidation-Reduction, Signal Transduction, Apoptosis, Oxidative Stress, Phosphatidylinositol 3-Kinases, Flavanones, Proto-Oncogene Proteins c-akt, NF-E2-Related Factor 2, Spatial Learning

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