The DOI matches its Crossref record.
Inhibition of CD26 in Human Cord Blood CD34 + Cells Enhances Their Engraftment of Nonobese Diabetic/Severe Combined Immunodeficiency Mice
Abstract
CD26, a surface serine dipeptidylpeptidase IV (DPPIV) expressed on different cell types, cleaves the amino-terminal dipeptide from some chemokines, including stromal-derived factor-1 (SDF-1/CXCL12). SDF-1/CXCL12 plays important roles in hematopoietic stem cell (HSC) homing, engraftment, and mobilization. Inhibition of CD26 peptidase activity enhances homing, engraftment, and competitive repopulation in congenic mouse bone marrow cell transplants. Our studies evaluated a role for CD26 in in vivo engraftment of HSCs from human umbilical cord blood (CB) into nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice. Pretreating purified CD34(+) human CB cells with Diprotin A, a DPPIV inhibitor, for 15 min significantly enhanced engraftment. Treatment did not affect differentiation of CD34(+) cells in vivo, as measured phenotypically by human markers CD33, CD38, CD19, and CD34. We found that the percentage of CD26(+) cells within the more immature cells (CD34(+)CD38()) was significantly higher than in the more mature population (CD34(+)CD38(+)). These results suggest that inhibition of CD26 may be one way to enhance engraftment of limiting numbers of stem cells during CB transplantation.
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In the citing paper
“CD26 is a membrane bound extracellular peptidase which is found on a subset of hematopoietic cells and cleaves dipeptides from the N-terminus of polypeptide chains, including SDF 1, rendering the chemokine inactive[89–91].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [91]
In the citing paper
“CD26 is a membrane bound extracellular peptidase which is found on a subset of hematopoietic cells and cleaves dipeptides from the N-terminus of polypeptide chains, including SDF 1, rendering the chemokine inactive[89–91].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [91]
In the citing paper
“the inhibition of CD26 by short term exposure of the donor cells to Diprotin A in vitro has been shown to increase transplantation efficiency in syngeneic murine and human xenotransplantation models[91,92].”
From Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia (2009) · cites this paper as [91]
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Cited by
Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia
Herrmann, H., Sadovnik, I., Cerny-Reiterer, S., Rülicke, T., Stefanzl, G., Willmann, M., Hoermann, G., Bilban, M., Blatt, K., Herndlhofer, S., et al. (2014) · Blood · doi:10.1182/blood-2013-10-536078 · Cited by 223
Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion
Isern, J., Martín-Antonio, B., Ghazanfari, R., Martín, A. M., López, J. A., del Toro, R., Sánchez-Aguilera, A., Arranz, L., Martín-Pérez, D., Suárez-Lledó, M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.041 · Cited by 141
Finding the needle in the hay stack: Hematopoietic stem cells in Fanconi anemia
Müller, L. U. W., & Williams, D. A. (2009) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2009.03.010 · Cited by 31
Metadata
- Authors
- Campbell, T. B., Hangoc, G., Liu, Y., Pollok, K., & Broxmeyer, H. E.
- Affiliations
- Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202.
- Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202.
- Venue
- Stem Cells and Development
- Publisher
- SAGE Publications
- Published
- 2007-06
- Volume
- 16
- Issue
- 3
- Pages
- 347-354
- ISSN
- 1547-3287
- 1557-8534
- Cited by
- 98
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Inhibition of CD26 in Human Cord Blood CD34 + Cells Enhances Their Engraftment of Nonobese Diabetic/Severe Combined Immunodeficiency Mice. https://app.cochat.ai/papers/10.1089/scd.2007.9995
- The paper
- Campbell, T. B., Hangoc, G., Liu, Y., Pollok, K., & Broxmeyer, H. E. (2007). Inhibition of CD26 in Human Cord Blood CD34 + Cells Enhances Their Engraftment of Nonobese Diabetic/Severe Combined Immunodeficiency Mice. Stem Cells and Development. https://doi.org/10.1089/scd.2007.9995
