iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth

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Items 101–165 of 165

  1. Impaired Functional Connectivity Underlies Fragile X Syndrome
    Lital Gildin, Rossana Rauti, Ofir Vardi, Liron Kuznitsov-Yanovsky, Ben Meir Maoz, Menahem Segal, Dalit Ben‐Yosef · 2022 · International Journal of Molecular Sciences
  2. Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges
    Jiafeng Chen, Lijuan Huang, Yue Yang, Wei Xu, Qingchun Qin, Rongxing Qin, Xiaojun Liang, Xinyu Lai, Xiaoying Huang, Minshan Xie et al. · 2023 · Brain Sciences
  3. Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models
    Johanna Kaindl, Beate Winner · 2019 · Current topics in behavioral neurosciences
  4. Across Dimensions: Developing 2D and 3D Human iPSC-Based Models of Fragile X Syndrome
    Azalea Lee, Jie Xu, Zhexing Wen, Peng Jin · 2022 · Cells
  5. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability
    Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, Sylviane Marouillat, Rose‐Anne Thépault, Frédéric Laumonnier, Frédérique Bonnet‐Brilhault, Patrick Vourc’h et al. · 2018 · Neuroscience
  6. Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments
    Xue Zhang, Zilong Li, Yi Liu, Zhongtao Gai · 2020 · International Journal of Medical Sciences
  7. FMR1 loss in a human stem cell model reveals early changes to intrinsic membrane excitability
    Sara G. Susco, Mario A. Arias-García, Violeta G. López-Huerta, Amanda Beccard, Anne M. Bara, Jessica Moffitt, Justin A. Korn, Zhanyan Fu, Lindy E. Barrett · 2020 · Developmental Biology
  8. High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells
    Jack F.V. Hunt, Meng Li, Ryan D. Risgaard, Gene E. Ananiev, Scott A. Wildman, Fan Zhang, Tim S. Bugni, Xinyu Zhao, Anita Bhattacharyya · 2021 · Cells
  9. Transcriptomic Analysis of Human Fragile X Syndrome Neurons Reveals Neurite Outgrowth Modulation by the TGFβ/BMP Pathway
    Liron Kuznitsov-Yanovsky, Guy Shapira, Lital Gildin, Noam Shomron, Dalit Ben‐Yosef · 2022 · International Journal of Molecular Sciences
  10. From wings to whiskers to stem cells: why every model matters in fragile X syndrome research
    Soraya O. Sandoval, Natasha M. Méndez-Albelo, Zhiyan Xu, Xinyu Zhao · 2024 · Journal of Neurodevelopmental Disorders
  11. The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders
    Ricarda Breitmeyer, Pauline Jeckel, Udo Kraushaar, Richard Wüst, Andreas Jochen Fallgatter, Hansjürgen Volkmer · 2020 · Stem Cells Translational Medicine
  12. Using Two- and Three-Dimensional Human iPSC Culture Systems to Model Psychiatric Disorders
    Kimberly M. Christian, Hongjun Song, Guo‐li Ming · 2020 · Advances in neurobiology
  13. Human iPSC Models in Drug Discovery: Opportunities and Challenges
    Silva, M.C., Cross, A., Brandon, N.J., Haggarty, S.J. · 2017 · Comprehensive Medicinal Chemistry III
  14. FMRP Enhances the Translation of 4EBP2 mRNA during Neuronal Differentiation
    Jinbae Yu, Youngsik Woo, Heesun Kim, Sihyeon An, Sang Ki Park, Sung Key Jang · 2023 · International Journal of Molecular Sciences
  15. Genomics of autism spectrum disorder: approach to therapy
    Fatma Ayhan, Geneviève Konopka · 2018 · F1000Research
  16. Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals
    Giulia Cencelli, Laura Pacini, Anastasia De Luca, Ilenia Messia, Antonietta Gentile, Yunhee Kang, Veronica Nobile, Elisabetta Tabolacci, Peng Jin, Maria Giulia Farace et al. · 2023 · Cells
  17. Modelling Autistic Neurons with Induced Pluripotent Stem Cells
    Annie Kathuria, Carlo Sala, Chiara Verpelli, Jack Price · 2017 · Advances in anatomy, embryology and cell biology
  18. Progress in the molecular mechanisms of genetic epilepsies using patient‐induced pluripotent stem cells
    Ruijiao Zhou, Guohui Jiang, Xin Tian, Xuefeng Wang · 2018 · Epilepsia Open
  19. One-Step Generation of Seamless Luciferase Gene Knockin Using CRISPR/Cas9 Genome Editing in Human Pluripotent Stem Cells
    Meng Li, Jack F.V. Hunt, Anita Bhattacharyya, Xinyu Zhao · 2019 · Methods in molecular biology
  20. Using Induced Pluripotent Stem Cells to Investigate Complex Genetic Psychiatric Disorders
    Stephanie J. Temme, Brady J. Maher, Kimberly M. Christian · 2016 · Current Behavioral Neuroscience Reports
  21. Activity of Human-Specific Interlaminar Astrocytes in a Chimeric Mouse Model of Fragile X Syndrome
    Alexandria Anding, Baiyan Ren, Ragunathan Padmashri, Maria E. Burkovetskaya, Anna Dunaevsky · 2025 · International Journal of Molecular Sciences
  22. iPSCs-Derived Neurons and Brain Organoids from Patients
    Wanying Zhu, Lei Xu, Xinrui Li, Hao Hu, Shu-Ning Lou, Yan Liu · 2023 · Handbook of experimental pharmacology
  23. Stem Cell Technology for (Epi)genetic Brain Disorders
    Renzo J. M. Riemens, Edilene Siqueira Soares, Manel Esteller, Raúl Delgado‐Morales · 2017 · Advances in experimental medicine and biology
  24. FMRP Regulates Neurogenesis In Vivo in Xenopus laevis Tadpoles
    Regina L. Faulkner, Tyler J. Wishard, Christopher K. Thompson, Han-Hsuan Liu, Hollis T. Cline · 2015 · eNeuro
  25. Human Pluripotent Stem Cells in Modeling Human Disorders: the Case of Fragile X Syndrome
    Dan Vershkov, Nissim Benvenisty · 2016 · Regenerative Medicine
  26. Antisense oligonucleotides to KIF1A polymorphisms expand targets and rescue patient-derived neurons in vitro
    Michael V. Zuccaro, Randee E. Young, Jiangyuan Hu, Patricia Lanzano, Ekaterina Semenova, Xiaoqi Lin, Alicja A. Skowronski, Yufeng Shen, Tae Hyun Kim, Danny E. Miller et al. · 2026 · Nature Communications
  27. The Evolution of Stem Cells, Disease Modeling, and Drug Discovery for Neurological Disorders
    Cameron D. Pernia, Brian T. D. Tobe, Ryan O'Donnell, Evan Y. Snyder · 2020 · Stem Cells and Development
  28. Modeling Fragile X Syndrome Using Human Pluripotent Stem Cells
    Dan Vershkov, Tamir Ben‐Hur, Nissim Benvenisty · 2017 · Elsevier eBooks
  29. Using Human Induced Neural Precursor Cells to Define Early Neurodevelopmental Defects in Syndromic and Idiopathic Autism
    Robert Connacher, Emanuel M. DiCicco-Bloom, James H. Millonig · 2018 · Current Pharmacology Reports
  30. Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells
    Zoe A. Mattingly, Sundari Chetty · 2025 · Autism Research
  31. Advances in Human Stem Cells and Genome Editing to Understand and Develop Treatment for Fragile X Syndrome
    Xinyu Zhao, Anita Bhattacharyya · 2020 · Advances in neurobiology
  32. Directly reprogrammed fragile X syndrome dorsal forebrain precursor cells generate cortical neurons exhibiting impaired neuronal maturation
    Nicole Edwards, Catharina Combrinck, Amy McCaughey‐Chapman, Bronwen J. Connor · 2023 · Frontiers in Cellular Neuroscience
  33. Efficient generation of human induced pluripotent stem cells from urine samples of patients with Fragile X syndrome
    Olivier Dionne, Salomé Sabatié, Fléchère Fortin, François Corbin, Benoît Laurent · 2024 · Frontiers in Cell and Developmental Biology
  34. Células madre: limitaciones y oportunidades en el Perú.
    José Amiel-Pérez, Fanny Lys Casado · 2015 · Revista Peruana de Medicina Experimental y Salud Pública
  35. Identification of Molecular Signatures in Neural Differentiation and Neurological Diseases Using Digital Color-Coded Molecular Barcoding
    Debora Salerno, Alessandro Rosa · 2020 · Stem Cells International
  36. Division of labor in the growth cone by DSCR1
    Timothy S. Catlett, Timothy M. Gómez · 2016 · The Journal of Cell Biology
  37. Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype
    James J. Fink, Nathaniel Delaney-Busch, Ryan P. Dawes, Evanthia Nanou, Christopher J. Folts, Karthiayani Harikrishnan, Chris Martin Hempel, Hansini Upadhyay, Trinh Mai Nguyen, Himali Shroff et al. · 2024 · Communications Biology
  38. Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome
    Ziyan Zhang, Cameron Keyser, Yaxin Li, Breandan J. Rosolia, Morgan W. Porch, Wen Zhang, Bin Su, Jiang Chen Peng, Ruth Suzanne Zukin, Jingqi Yan · 2025 · Molecular Psychiatry
  39. Fragile X Syndrome Patient–Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes
    Marine Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Andrew S. Khalil, Tenzin Lungjangwa, Jennifer Shih et al. · 2021 · Biological Psychiatry
  40. Near-cognate initiation generates FMRpolyG from CGG repeats in Fragile X associated Tremor Ataxia Syndrome
    Yuan Zhang, M. R. Glineburg, V. Basrur, K. Conlon, Deborah A. Hall, Peter K. Todd · 2020 · bioRxiv
  41. Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies
    Fatima Azzahrae El Yacoubi, Mohamed Oukabli, Azeddine Ibrahimi, Hassan Kisra, Mounia Bensaid · 2023 · CNS & Neurological Disorders - Drug Targets
  42. EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons
    Minggang Fang, Sara K. Deibler, Pranathi Meda Krishnamurthy, Feng Wang, Paola María Rodríguez, Shahid Banday, Ching-Man A. Virbasius, Miguel Sena‐Esteves, Jonathan K. Watts, Michael R. Green · 2024 · Frontiers in Neuroscience
  43. Human iPSC Models: A Platform for Investigating Neurodevelopmental Diseases
    Cindy E. McKinney · 2014 · Journal of Molecular and Genetic Medicine
  44. Brain in a Dish
    Cleber A. Trujillo, Priscilla Davidson Negraes, Branka Hrvoj-Mihić, Mauro F.C. Lins, Katerina Semendeferi, Alysson Renato Muotri · 2016 · Elsevier eBooks
  45. Induced pluripotent stem cells as models of human neurodevelopmental disorders
    Alexandre Jourdon, Jessica Mariani, Soraya Scuderi, Anahita Amiri, Feinan Wu, Eunice Y. Yuen, Alexej S. Abyzov, Flora Maria Vaccarino · 2020 · Elsevier eBooks
  46. Stem Cell Epigenetics and Human Disease
    Leila Larijani, Derrick E. Rancourt · 2018 · Elsevier eBooks
  47. Disease‐Specific Stem Cell Models for Toxicological Screenings and Drug Development
    Matthias Jung, Juliane‐Susanne Jung, Jovita Schiller, Insa S. Schroeder · 2016 · Wiley eBooks
  48. Avaliação de componentes de risco para o Transtorno do Espectro do Autismo em participantes do Projeto a Fada do Dente
    Anita Jovelina Brito de Jesus · 2020 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  49. From Human Pluripotent Stem Cells to Neurons: Promises and Pitfalls
    Ralda Nehme, Jon M. Madison · 2014 · Wiley eBooks
  50. Human iPSC Models: A Platform for Investigating Neurodevelopmental
    DiseasesE McKinney, Stephan Brown · 2014
  51. Stem Cells to Understand the Pathophysiology of Autism Spectrum Disorders
    Maria Rita Passos‐Bueno, Karina Griesi‐Oliveira, Andrea Laurato Sertie, Gerson Shigeru Kobayashi · 2015 · Stem cell biology and regenerative medicine
  52. Investigação da etiologia de malformações craniofaciais com uso de células derivadas de crista neural
    Gerson Shigeru Kobayashi · 2016 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  53. Estudo de expressão gênica em células neurais derivadas de células-tronco pluripotentes induzidas de indivíduos com Transtorno do Espectro Autista
    Mariana Soares Fogo · 2019 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  54. Psychiatrische Erkrankungen mit Stammzelltechnologien verstehen
    Ricarda Stock, Hansjürgen Volkmer · 2020 · BIOspektrum
  55. Human pluripotent stem cells in the research of Fragile X Syndrome
    Michael Telias · 2021 · Elsevier eBooks
  56. Human-mouse chimeric Fragile X syndrome model reveals FMR1-dependent neuronal phenotypes
    Marine Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Aaron N. Chang, Stephen T. Warren, Angela M. Cacace et al. · 2020 · Research Square
  57. Implicações de variantes bialélicas de perda de função no gene TBCK, no transporte de vesículas de células progenitoras neurais derivadas de células-tronco pluripotentes induzidas
    Ângela May Suzuki · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  58. Faculty Opinions recommendation of Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
    Eric Hollander, Genoveva Uzunova · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  59. Metabolic stress and antipsychotic treatment induced gene expression alterations in human cell
    Sára Kálmán · 2016 · SZTE Repository of Dissertations (University of Szeged)
  60. Faculty Opinions recommendation of Modeling autism spectrum disorders with human neurons.
    Geneviève Konopka · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  61. MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway
    Maolei Gong, Jiayi Li, Yijun Liu, Matheus Vernet Machado Bressan Wilke, Qian Li, Haoran Liu, Liang Chen, Joel A. Morales‐Rosado, Ana S.A. Cohen, Susan Starling Hughes et al. · 2024 · medRxiv
  62. Use of brain organoids for autism
    Ajay Elangovan, Nitin Kumar, Arvinder Wander, Tanja Maria Michel · 2025 · Elsevier eBooks
  63. Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery
    Eliška Kuchovská, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, N. Görts, D. Polozij, L.-C. Saborowski et al. · 2026 · Advanced Science
  64. Epigenetic regulator KDM5B loss-of-function delays neuronal differentiation of human iPSCs
    Jack Harrington, Amal Alenad, Jane Gibson, Gabrielle Wheway, Sandrine Willaime‐Morawek, Zoë Walters · 2026 · Research Square
  65. Human iPSC-Derived Brain Cells, Organoids, and Organoids-on-Chips: Advancing Neurological Disease Modeling to Improve Clinical Outcome
    Gabriel Burdman, Marco Hanna, Adriana Yndart, Arti Vashist, Madepalli Krishnappa Lakshmana · 2026 · Cells