The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?
Open accessAbstract
Cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are increasingly used to model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a major hurdle to more extensive use is their immaturity and similarity to fetal rather than adult cardiomyocytes. Here, we provide an overview of the strategies currently being used to increase maturation in culture, which include prolongation of time in culture, exposure to electrical stimulation, application of mechanical strain, growth in three-dimensional tissue configuration, addition of non-cardiomyocytes, use of hormones and small molecules, and alteration of the extracellular environment. By comparing the outcomes of these studies, we identify the approaches most likely to improve functional maturation of hPSC-CMs in terms of their electrophysiology and excitation-contraction coupling.
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Cites
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Cited by
Denning, C., Borgdorff, V., Crutchley, J., Firth, K. S. A., George, V., Kalra, S., Kondrashov, A., Hoang, M. D., Mosqueira, D., Patel, A., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.014 · Cited by 293
Beauchamp, P., Jackson, C. B., Ozhathil, L. C., Agarkova, I., Galindo, C. L., Sawyer, D. B., Suter, T. M., & Zuppinger, C. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00014 · Cited by 202
Development of a human cardiac organoid injury model reveals innate regenerative potential
Voges, H. K., Mills, R. J., Elliott, D. A., Parton, R. G., Porrello, E. R., & Hudson, J. E. (2017) · Development · doi:10.1242/dev.143966 · Cited by 196
View from the heart: cardiac fibroblasts in development, scarring and regeneration
Furtado, M. B., Nim, H. T., Boyd, S. E., & Rosenthal, N. A. (2016) · Development · doi:10.1242/dev.120576 · Cited by 144
Li, S., Pan, H., Tan, C., Sun, Y., Song, Y., Zhang, X., Yang, W., Wang, X., Li, D., Dai, Y., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.013 · Cited by 106
Metadata
- Authors
- Veerman, C. C., Kosmidis, G., Mummery, C. L., Casini, S., Verkerk, A. O., & Bellin, M.
- Venue
- Stem Cells and Development
- Publisher
- SAGE Publications
- Published
- 2015-05
- Volume
- 24
- Issue
- 9
- Pages
- 1035-1052
- ISSN
- 1525-8165 (ISSN-L)
- 1547-3287
- 1557-8534
- OpenAlex
- W1747672433
- Cited by
- 265
- References
- 158
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Veerman, C. C., Kosmidis, G., Mummery, C. L., Casini, S., Verkerk, A. O., & Bellin, M. (2015). Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem? Stem Cells and Development. https://doi.org/10.1089/scd.2014.0533
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