The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Antibiotic Prophylaxis in Pediatric Cardiac Surgery: Where Are We and Where Do We Go? A Systematic Review
Abstract
Background: Prophylactic antibiotic therapy is given routinely in the peri-operative period to prevent surgical site infection. However, in pediatric cardiac surgery, an optimal schedule has not been defined. Pediatric recommendations follow the guidelines for adults, which might be improper because of the inherent challenges in pediatric research and the heterogeneity of the population. Implementation of an effective prophylaxis protocol is needed for children undergoing cardiac surgery, especially in view of worldwide antibiotic overuse and the development of drug resistance. In this review, we analyze the current knowledge supported by up-to-date publications about antibiotic prophylaxis in pediatric cardiac surgery. Methods: The PubMed® database was searched for full-text journal articles describing peri-operative antibiotic prophylaxis in pediatric cardiac surgery published since 2000. Antibiotics used for standard prophylaxis with dosing schema, time of the first dose, additional dosage in extracorporeal circulation (ECC) priming, and prophylaxis duration were analyzed. Additionally, we looked for special clinical situations such as antibiotic prophylaxis in children with the sternum left open after surgery and patients with β-lactam allergy or pre-operative methicillin-resistant Staphylococcus aureus (MRSA) colonization or those requiring extracorporeal membrane oxygenation (ECMO). Results: A total of 1,546 articles were evaluated, and we identified 20 for further analysis. On the basis of the current peri-operative antibiotic prophylaxis recommendations for cardiac surgery and the papers reviewed, we tried to propose a schedule for peri-operative antibiotic prophylaxis in pediatric cardiac surgery. Conclusions: There is a need for careful use and examination of the schedule proposed because the pharmacokinetics of antibiotics in pediatric patients with ECC is not fully understood. This should be evaluated further. Formulating uniform recommendations concerning peri-operative antibiotic prophylaxis is difficult.
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“The studies in LMICs focus on surgical prophylaxis,17–20 overlooking the extent of post-operative empirical antibiotic use.”
From Rationalizing irrational prescribing—infection-related attitudes and practices across paediatric surgery specialties in a hospital in South India (2024) · cites this paper as [19]
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
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Clinical practice guidelines for antimicrobial prophylaxis in surgery
Bratzler, D. W., Dellinger, E. P., Olsen, K. M., Perl, T. M., Auwaerter, P. G., Bolon, M. K., Fish, D. N., Napolitano, L. M., Sawyer, R. G., Slain, D., et al. (2013) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp120568 · Cited by 2,591
Bennett‐Guerrero, E. (2010) · JAMA · doi:10.1001/jama.2010.1152 · Cited by 136
Risk Factors for Surgical Site Infection After Cardiac Surgery in Children
Costello, J. M., Graham, D. A., Morrow, D. F., Morrow, J., Potter-Bynoe, G., Sandora, T. J., Pigula, F. A., & Laussen, P. C. (2010) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2009.08.081 · Cited by 132
Nateghian, A., Taylor, G., & Robinson, J. L. (2004) · American Journal of Infection Control · doi:10.1016/j.ajic.2004.03.004 · Cited by 105
Kowalewski, M., Pawliszak, W., Zaborowska, K., Navarese, E. P., Szwed, K. A., Kowalkowska, M. E., Kowalewski, J., Borkowska, A., & Anisimowicz, L. (2015) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2015.01.034 · Cited by 91
Harder, E. E., Gaies, M., Yu, S., Donohue, J. E., Hanauer, D. A., Goldberg, C. S., & Hirsch, J. C. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.09.062 · Cited by 78
Dose optimization of piperacillin/tazobactam in critically ill children
Cock, P. A. J. G. D., van Dijkman, S. C., Jaeger, A. D., Willems, J., Carlier, M., Verstraete, A., Delanghe, J., Robays, H., Walle, J. V., Pasqua, O. E. D., et al. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx093 · Cited by 73
Maher, K. O., VanderElzen, K., Bove, E. L., Mosca, R. S., Chenoweth, C., & Kulik, T. J. (2002) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)03893-6 · Cited by 51
A Statewide Collaborative to Reduce Pediatric Surgical Site Infections
Toltzis, P., O’Riordan, M., Cunningham, D. J., Ryckman, F. C., Bracke, T. M., Olivea, J., & Lyren, A. (2014) · PEDIATRICS · doi:10.1542/peds.2014-0097 · Cited by 51
Cited by
Antibiotic prophylaxis for surgical procedures: a scoping review
Brocard, E., Revéiz, L., Régnaux, J.-P., Abdala, C. V. M., Ramón-Pardo, P., & del Rio Bueno, A. (2021) · Revista Panamericana de Salud Pública · doi:10.26633/rpsp.2021.62 · Cited by 28
Reducing Broad-Spectrum Antimicrobial Use in Extracorporeal Membrane Oxygenation: Reduce AMMO Study
Shah, A., Sampathkumar, P., Stevens, R. W., Bohman, J. K., Lahr, B. D., Dhungana, P., Vashistha, K., & O’Horo, J. C. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab118 · Cited by 27
Yeo, H. J., Kim, D., Ha, M., Je, H. G., Kim, J. S., & Cho, W. H. (2020) · Critical Care · doi:10.1186/s13054-020-03310-w · Cited by 27
Occurrence, associated risk factors, and treatment of surgical site infections in Pakistan
Khan, F. U., Fang, Y., Khan, Z., Khan, F. U., Malik, Z. I., Ahmed, N., Khan, A., & Rehman, A. U. (2020) · European Journal of Inflammation · doi:10.1177/2058739220960547 · Cited by 28
Impact of a Surgical Wound Infection Prevention Bundle in Pediatric Cardiothoracic Surgery
Glenn, E. T., Harman, J. R., Marietta, J., Lake, J. G., Bailly, D. K., Ou, Z., Griffiths, E. R., & Ware, A. L. (2022) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2022.08.045 · Cited by 18
Metadata
- Authors
- Jaworski, R., Kansy, A., Dzierzanowska-Fangrat, K., & Maruszewski, B.
- Affiliations
- Department of Pediatric Cardiothoracic Surgery, Children's Memorial Health Institute, Warsaw, Poland.
- Children's Memorial Health Institute (PL)
- Department of Clinical Microbiology and Immunology, Children's Memorial Health Institute, Warsaw, Poland.
- Venue
- Surgical Infections
- Publisher
- SAGE Publications
- Published
- 2019-05
- Volume
- 20
- Issue
- 4
- Pages
- 253-260
- ISSN
- 1096-2964 (ISSN-L)
- 1557-8674
- OpenAlex
- W2911342992
- Cited by
- 39
- References
- 29
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
- Locations
- Surgical Infections (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Keywords
- antibiotic prophylaxis, pediatric cardiac surgery, surgical site infection, antibiotic dosing schedule, antibiotic resistance, antibiotic overuse, beta-lactam allergy, MRSA colonization, extracorporeal membrane oxygenation, pediatric pharmacokinetics
- MeSH terms
- Anti-Bacterial Agents, Hospitals, Pediatric, Humans, Surgical Wound Infection, Thoracic Surgery, Antibiotic Prophylaxis, Thoracic Surgical Procedures, Perioperative Care
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- The paper
- Jaworski, R., Kansy, A., Dzierzanowska-Fangrat, K., & Maruszewski, B. (2019). Antibiotic Prophylaxis in Pediatric Cardiac Surgery: Where Are We and Where Do We Go? A Systematic Review. Surgical Infections. https://doi.org/10.1089/sur.2018.272
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
