The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Three-Dimensional Printed Multiphase Scaffolds for Regeneration of Periodontium Complex
Open accessAbstract
Tooth-supporting periodontium forms a complex with multiple tissues, including cementum, periodontal ligament (PDL), and alveolar bone. In this study, we developed multiphase region-specific microscaffolds with spatiotemporal delivery of bioactive cues for integrated periodontium regeneration. Polycarprolactione-hydroxylapatite (90:10 wt%) scaffolds were fabricated using three-dimensional printing seamlessly in three phases: 100-μm microchannels in Phase A designed for cementum/dentin interface, 600-μm microchannels in Phase B designed for the PDL, and 300-μm microchannels in Phase C designed for alveolar bone. Recombinant human amelogenin, connective tissue growth factor, and bone morphogenetic protein-2 were spatially delivered and time-released in Phases A, B, and C, respectively. Upon 4-week in vitro incubation separately with dental pulp stem/progenitor cells (DPSCs), PDL stem/progenitor cells (PDLSCs), or alveolar bone stem/progenitor cells (ABSCs), distinctive tissue phenotypes were formed with collagen I-rich fibers especially by PDLSCs and mineralized tissues by DPSCs, PDLSCs, and ABSCs. DPSC-seeded multiphase scaffolds upon in vivo implantation yielded aligned PDL-like collagen fibers that inserted into bone sialoprotein-positive bone-like tissue and putative cementum matrix protein 1-positive/dentin sialophosphoprotein-positive dentin/cementum tissues. These findings illustrate a strategy for the regeneration of multiphase periodontal tissues by spatiotemporal delivery of multiple proteins. A single stem/progenitor cell population appears to differentiate into putative dentin/cementum, PDL, and alveolar bone complex by scaffold's biophysical properties and spatially released bioactive cues.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Fully functional bioengineered tooth replacement as an organ replacement therapy
Ikeda, E., Morita, R., Nakao, K., Ishida, K., Nakamura, T., Takano-Yamamoto, T., Ogawa, M., Mizuno, M., Kasugai, S., & Tsuji, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902944106 · Cited by 447
Cited by
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
Tatullo, M., Marrelli, M., Shakesheff, K. M., & White, L. J. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1899 · Cited by 353
Regenerative Medicine for Periodontal and Peri-implant Diseases
Larsson, L., Decker, A. M., Nibali, L., Pilipchuk, S. P., Berglundh, T., & Giannobile, W. V. (2016) · Journal of Dental Research · doi:10.1177/0022034515618887 · Cited by 300
Recent advances in periodontal regeneration: A biomaterial perspective
Liang, Y., Luan, X., & Liu, X. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.02.012 · Cited by 281
Metadata
- Authors
- Lee, C. H., Hajibandeh, J., Suzuki, T., Fan, A., Shang, P., & Mao, J. J.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2014-04
- Volume
- 20
- Issue
- 7-8
- Pages
- 1342-1351
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- OpenAlex
- W2023758332
- Cited by
- 234
- References
- 2
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, C. H., Hajibandeh, J., Suzuki, T., Fan, A., Shang, P., & Mao, J. J. (2014). Three-Dimensional Printed Multiphase Scaffolds for Regeneration of Periodontium Complex. Tissue Engineering Part A. https://doi.org/10.1089/ten.tea.2013.0386
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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