CoChat
Sign Up
Cited by 8Facial Trauma and Fracture ManagementBone Tissue Engineering MaterialsBone fractures and treatments

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

The Promoting Effect of a Local Pulsatile Parathyroid Hormone Delivery on Healing of the Mandibular Fracture in Rats

Jia, Yuanyuan, Duan, Mianmian, Yang, Yan, Wang, Dongxiang, Dong, Qiang, Liao, Jian, Mao, Ling, Liu, Poyu, Feng, Ling, Chen, Jin, Tang, Zhenglong·2023·Tissue Engineering Part A
DOI 10.1089/ten.tea.2022.0136
Open this paper in CoChat — free account

Abstract

Parathyroid hormone (PTH) can promote bone formation and mineralization in mandibular fractures, and is systemically administered through daily injections. In this study, the local delivery of PTH using carboxymethyl chitosan/polyvinyl alcohol and alginate was investigated. Bovine serum albumin was used as a drug substitute, and the delivery system was verified to release drugs in a pulsed rhythm. After the delivery system was subcutaneously implanted in Sprague–Dawley (SD) rats, no rejection reaction was detected, indicating that it has good biocompatibility and biodegradability in vivo. Then, an SD rat model of mandibular fracture was established, and 24 rats were randomly divided into two groups. The control group was reduced and fixed with screws and a microplate, and the experimental group received pulsatile PTH release system (14 μg PTH) + screws and microplate fixation. The animals were euthanized on postoperative weeks 1–4. Observation of gross specimens, digital radiography, and hematoxylin and eosin showed that the local PTH pulsatile release system promoted osteogenesis and accelerated fracture healing. In summary, PTH can be loaded by biomaterials to locally target the fracture and stimulate bone formation. Moreover, the pulsatile PTH release system provides a potential therapeutic protocol for mandibular fracture. Our study prepares a drug release system that could impulsively release parathyroid hormone. The system could enhance bone regeneration in rats with mandibular fracture. These data provide a foundation for future studies aimed to understand and optimize the use of bioactive molecule pulsatile delivery for bone regeneration and tissue engineering applications.

Overview

Integrity signals

Registry

Crossref · 10.1089/ten.tea.2022.0136

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Uzawa T., 1995, Bone, 16, 477
  2. Thiruchelvam N, 2014, Case Rep Endocrinol, 2014, 802473

Cited by

Sorted by citations

Related

Metadata

Authors
Jia, Y., Duan, M., Yang, Y., Wang, D., Dong, Q., Liao, J., Mao, L., Liu, P., Feng, L., Chen, J., & Tang, Z.
Affiliations
  • Guiyang Medical University (CN)
  • Key Laboratory of Biology and Medical Engineering/Immune Cells and Antibody Engineering Research Center of Guizhou Province, School of Biology and Engineering, Guiyang, China.
Corresponding author
Tang, Zhenglong
ORCID
Venue
Tissue Engineering Part A
Publisher
SAGE Publications
Published
2023-02-01
Volume
29
Issue
3-4
Pages
69-79
ISSN
  • 1937-3341 (ISSN-L)
  • 1937-335X
DOI
10.1089/ten.tea.2022.0136
OpenAlex
W4302761027
Cited by
8
References
34
Citations by year
2026: 4 · 2025: 3 · 2024: 1
FWCI
0.95
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Tissue Engineering Part A (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Facial Trauma and Fracture Management
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
Keywords
parathyroid hormone, mandibular fractures, fracture healing, pulsatile drug delivery, local drug delivery, carboxymethyl chitosan, polyvinyl alcohol, alginate, bone formation, bone regeneration, biodegradable biomaterials, biocompatibility, bone tissue engineering
MeSH terms
Animals, Bone Regeneration, Mandibular Fractures, Parathyroid Hormone, Fracture Healing, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review