The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Mechanical Properties of Natural Cartilage and Tissue-Engineered Constructs
Abstract
There has been much research over the past two decades with the aim of engineering cartilage constructs for repairing or restoring damaged cartilage. To engineer healthy neocartilage, the constructs must have mechanical properties matching those of native cartilage as well as appropriate for the loading conditions of the joint. This article discusses the mechanical behavior of native cartilage and surveys different types of tensile, compressive, and shear tests with their limitations. It also comprehensively reviews recent work and achievements in developing the mathematical models representing the mechanical properties of both native and engineered cartilage. Different methods for enhancing the mechanical properties of engineered cartilage are also discussed, including scaffold design, mechanical stimulation, and chemical stimulation. This article concludes with recommendations for future research aimed at achieving engineered cartilage with mechanical properties matching those found in native cartilage.
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Cites
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Cited by
Ultrastiff and Tough Supramolecular Hydrogels with a Dense and Robust Hydrogen Bond Network
Wang, Y. J., Zhang, X. N., Song, Y., Zhao, Y., Chen, L., Su, F., Li, L., Wu, Z. L., & Zheng, Q. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.8b05262 · Cited by 417
Prasadh, S., & Wong, R. C. W. (2018) · Oral Science International · doi:10.1016/s1348-8643(18)30005-3 · Cited by 283
Biomaterials / bioinks and extrusion bioprinting
Chen, X. B., Fazel Anvari-Yazdi, A., Duan, X., Zimmerling, A., Gharraei, R., Sharma, N. K., Sweilem, S., & Ning, L. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.06.006 · Cited by 244
Li, Q., Xu, S., Feng, Q., Dai, Q., Yao, L., Zhang, Y., Gao, H., Dong, H., Chen, D., & Cao, X. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.013 · Cited by 231
Beck, E. C., Barragan, M., Tadros, M. H., Gehrke, S. H., & Detamore, M. S. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.04.019 · Cited by 222
Metadata
- Authors
- Little, C. J., Bawolin, N. K., & Chen, X.
- Venue
- Tissue Engineering Part B: Reviews
- Publisher
- SAGE Publications
- Published
- 2011-04-19
- Volume
- 17
- Issue
- 4
- Pages
- 213-227
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W2032710553
- Cited by
- 314
- References
- 85
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Little, C. J., Bawolin, N. K., & Chen, X. (2011). Mechanical Properties of Natural Cartilage and Tissue-Engineered Constructs. Tissue Engineering Part B: Reviews. https://doi.org/10.1089/ten.teb.2010.0572
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
