The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Relative Potencies and Additivity of Perchlorate, Thiocyanate, Nitrate, and Iodide on the Inhibition of Radioactive Iodide Uptake by the Human Sodium Iodide Symporter
Abstract
The presence of perchlorate (ClO(4) (-)) in some U.S. drinking water supplies has raised concern about potential adverse thyroidal health effects, because ClO(4) (-) is known to competitively inhibit iodide uptake at the sodium iodide symporter (NIS). Humans are nutritionally and environmentally exposed to other competitive inhibitors of iodide uptake, including thiocyanate (SCN(-)) and nitrate (NO(3) (-)). The joint inhibiting effects of these three anions was studied by exposing Chinese hamster ovary cells stably expressing human NIS to varying concentrations of each anion separately, and in combination, and conducting measurements of (125)I(-) uptake. The entire data set was fit to a single Hill equation using maximum likelihood. The relative potency of ClO(4) (-) to inhibit (125)I(-) uptake at the NIS was found to be 15, 30 and 240 times that of SCN(-), I(-), and NO(3) (-) respectively on a molar concentration basis, with no evidence of synergism. These results are consistent with a common mode of action by these anions of simple competitive interaction, in which a concentration of any one of ClO(4) (-) SCN(-), and NO(3) (-), occurring either individually or as part of a mixture of the three anions, is indistinguishable from a concentration or dilution of either one of the remaining two ions in inhibiting iodine uptake at the NIS.
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Citations
Cites
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A method for computing profile-likelihood-based confidence intervals
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Perchlorate as an environmental contaminant
Urbansky, E. T. (2002) · Environmental Science and Pollution Research · doi:10.1007/bf02987487 · Cited by 343
THE EFFECT OF CERTAIN ANIONS UPON THE ACCUMULATION AND RETENTION OF IODIDE BY THE THYROID GLAND*
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Thyroid Health Status of Ammonium Perchlorate Workers: A Cross-Sectional Occupational Health Study
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Nitrate and nitrite in vegetables on the Danish market: content and intake
Petersen, A., & Stoltze, S. (1999) · Food Additives & Contaminants · doi:10.1080/026520399283957 · Cited by 120
Dietary exposures to nitrate in the UK
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Does Perchlorate in Drinking Water Affect Thyroid Function in Newborns or School-Age Children?
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Cited by
Wiersinga, W. M. (2013) · Clinical Endocrinology · doi:10.1111/cen.12222 · Cited by 389
Nitrate Intake and the Risk of Thyroid Cancer and Thyroid Disease
Ward, M. H., Kilfoy, B. A., Weyer, P. J., Anderson, K. E., Folsom, A. R., & Cerhan, J. R. (2010) · Epidemiology · doi:10.1097/ede.0b013e3181d6201d · Cited by 359
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Perchlorate, iodine and the thyroid
Leung, A. M., Pearce, E. N., & Braverman, L. E. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.08.009 · Cited by 152
Re‐evaluation of sodium nitrate (E 251) and potassium nitrate (E 252) as food additives
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Metadata
- Authors
- Tonacchera, M., Pinchera, A., Dimida, A., Ferrarini, E., Agretti, P., Vitti, P., Santini, F., Crump, K., & Gibbs, J.
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2004-12
- Volume
- 14
- Issue
- 12
- Pages
- 1012-1019
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2068424371
- Cited by
- 344
- References
- 29
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Relative Potencies and Additivity of Perchlorate, Thiocyanate, Nitrate, and Iodide on the Inhibition of Radioactive Iodide Uptake by the Human Sodium Iodide Symporter. https://app.cochat.ai/papers/10.1089/thy.2004.14.1012
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- Tonacchera, M., Pinchera, A., Dimida, A., Ferrarini, E., Agretti, P., Vitti, P., Santini, F., Crump, K., & Gibbs, J. (2004). Relative Potencies and Additivity of Perchlorate, Thiocyanate, Nitrate, and Iodide on the Inhibition of Radioactive Iodide Uptake by the Human Sodium Iodide Symporter. Thyroid. https://doi.org/10.1089/thy.2004.14.1012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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