Intrauterine diagnosis and management of fetal goitrous hypothyroidism: a report of an Iranian family with three consecutive pregnancies complicated by fetal Goiter
Abstract
The diagnosis and treatment of hypothyroidism during the fetal period may decrease perinatal morbidity and are believed to be important to optimize growth and intellectual development. Herewith a case report of fetal goitrous hypothyroidism is presented in a euthyroid mother, detected at 34 weeks' gestation by ultrasonography, and treated with intra-amniotic levothyroxine injections. The mother had two previous consecutive pregnancies (13 and 8 years ago), also complicated by the occurrence of fetal goiter, resulting in tracheal compression, asphyxia, and early neonatal death in the first and in an emergency cesarean section delivery, because of fetal malpresentation, in the second neonate affected by congenital hypothyroidism (CH). The present male newborn, although born without observable goiter, had a large thyroid on ultrasonography and an early rise of his peripheral venous blood thyrotropin confirmed the diagnosis of CH. Low serum thyroglobulin in the proband and his older brother and parental consanguinity was mostly compatible with a thyroglobulin defective synthesis and secretion as the cause of CH and fetal goiter. Despite apparently sufficient dose of intraamniotic levothyroxine injections repeated weekly from 34-37 weeks' gestation (i.e., four injections of 500 microg levothyroxine), neonatal bone age on the second day of life showed delayed skeletal maturation.
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Genetic mutations of thyroid-specific proteins play a role in the development of fetal goiters.
“Genetic mutations of thyroid-specific proteins also play a role in the development of fetal goiters (249–251).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [250]
Cites
Micro determination of iodine by a catalytic method
Sandell, E. B., & Kolthoff, I. M. (1937) · Microchimica Acta · doi:10.1007/bf01476194 · Cited by 591 · see citing works
Resistance to Thyrotropin Caused by Mutations in the Thyrotropin-Receptor Gene
Sunthornthepvarakul, T., Gottschalk, M. E., Hayashi, Y., & Refetoff, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320305 · Cited by 340 · see citing works
Newborn Screening for Congenital Hypothyroidism: Recommended Guidelines
AAP Section on Endocrinology and Committee on Genetics, A. A. T. A. C. O. P. H. (1993) · PEDIATRICS · doi:10.1542/peds.91.6.1203 · Cited by 237 · see citing works
Iodine supplementation of pregnant women in Europe: a review and recommendations
Zimmermann, M. B., & Delange, F. M. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601933 · Cited by 230 · see citing works
Neonatal Screening for Congenital Hypothyroidism Results and Perspectives
Delange, F. (1997) · Hormone Research · doi:10.1159/000185485 · Cited by 224 · see citing works
Physiological variations in thyroid hormones: physiological and pathophysiological considerations
Fisher, D. A. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.1.135 · Cited by 207 · see citing works
Intellectual outcome in children with fetal hypothyroidism
ROVET, J. F., Ehrlich, R., & Sorbara, D. (1987) · The Journal of Pediatrics · doi:10.1016/s0022-3476(87)80005-7 · Cited by 190 · see citing works
Fetal and neonatal thyroid function in relation to maternal Graves' disease
Polak, M., Gac, I. L., VUILLARD, E., Guibourdenche, J., Léger, J., Toubert, M., Madec, A., Oury, J., Czernichow, P., & Luton, D. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.03.009 · Cited by 159 · see citing works
Successful in Utero Treatment of Fetal Goiter and Hypothyroidism
Davidson, K. M., RICHARDS, D. S., Schatz, D., & Fisher, D. A. (1991) · New England Journal of Medicine · doi:10.1056/nejm199102213240807 · Cited by 139 · see citing works
Early Treatment of Congenital Hypothyroidism
Fisher, D. A., & Foley, B. (1989) · PEDIATRICS · doi:10.1542/peds.83.5.785 · Cited by 109 · see citing works
Intrauterine Diagnosis and Treatment of Fetal Goitrous Hypothyroidism
PERELMAN, A. H., JOHNSON, R. L., Clemons, R. D., Finberg, H. J., Clewell, W. H., & TRUJILLO, L. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-3-618 · Cited by 102 · see citing works
Abuhamad, A. Z., Fisher, D. A., Warsof, S. L., Slotnick, R. N., Pyle, P. G., Wu, S., & Evans, A. T. (1995) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1995.06050368.x · Cited by 100 · see citing works
Ultrasound of the thyroid gland in the newborn: normative data
Perry, R., Hollman, A. S., Wood, A. M., & Donaldson, M. D. C. (2002) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.87.3.f209 · Cited by 91 · see citing works
Diagnostic Fetal Blood Sampling-Technique Related Losses
Weiner, C. P., & Okamwa, K. (2009) · Fetal Diagnosis and Therapy · doi:10.1159/000264298 · Cited by 85 · see citing works
Thyroid Gland Volume Estimated by Use of Ultrasound In Addition to Scintigraphy
Brown, M. C., & Spencer, R. (1978) · Acta Radiologica Oncology Radiation Physics Biology · doi:10.3109/02841867809127937 · Cited by 80 · see citing works
Caron, P., Moya, C. M., Malet, D., Gutnisky, V. J., Chabardes, B., Rivolta, C. M., & Targovnik, H. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021744 · Cited by 78 · see citing works
Intrauterine diagnosis and management of congenital goitrous hypothyroidism
Agrawal, P., Ogilvy‐Stuart, A., & Lees, C. C. (2002) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.2002.00717.x · Cited by 77 · see citing works
Antenatal diagnosis and treatment of a fetal goiter.
WEINER, S. A., Scharf, J. I., Bolognese, R. J., & Librizzi, R. J. (1980) · PubMed · Cited by 66 · see citing works
Ho, S. S. Y., & Metreweli, C. (1998) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1998.11020118.x · Cited by 65 · see citing works
Establishment of Reference Intervals for Markers of Fetal Thyroid Status in Amniotic Fluid
Singh, P. K., Parvin, C. A., & Gronowski, A. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030522 · Cited by 64 · see citing works
Grüner, C., Kollert, A., Wildt, L., Dörr, H. G., Beinder, E., & Lang, N. (2000) · Fetal Diagnosis and Therapy · doi:10.1159/000053880 · Cited by 59 · see citing works
Morine, M., Takeda, T., Minekawa, R., et al. (2002) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.2002.00680.x · Cited by 53 · see citing works
A High Prevalence of Consanguineous and Severe Congenital Hypothyroidism in an Iranian Population
Ordookhani, A., Mirmiran, P., Moharamzadeh, M., Hedayati, M., & Azizi, F. (2004) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2004.17.9.1201 · Cited by 53 · see citing works
Self-citationPrenatal diagnosis and early in utero management of fetal dyshormonogenetic goiter
Perrotin, F., Sembély-Taveau, C., Haddad, G., et al. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00346-8 · Cited by 46 · see citing works
Autoimmune Thyroid Disease and Pregnancy: Relevance for the Child
Dallas, J. S. (2003) · Autoimmunity · doi:10.1080/08916930310001602993 · Cited by 45 · see citing works
New Standards of Ossification of the Newborn
Kuhns, L. R., & Finnström, O. (1976) · Radiology · doi:10.1148/119.3.655 · Cited by 44 · see citing works
Medeiros-Neto, G. A., Bunduki, V., Tomimori, E. K., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4407 · Cited by 38 · see citing works
Early Prenatal Diagnosis and Therapy of Fetal Hypothyroid Goiter
Noia, G., Santis, M. D., Tocci, A., et al. (2009) · Fetal Diagnosis and Therapy · doi:10.1159/000263661 · Cited by 33 · see citing works
Hollingsworth, D. R., & Alexander, N. M. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-2-349 · Cited by 33 · see citing works
Intra-amniotic injection of thyroxine (T4) to a human fetus
Lightner, E. S., Fismer, D. A., Giles, H. R., et al. (1977) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(77)90440-9 · Cited by 32 · see citing works
Intrauterine Treatment of Thyroid Goiters
Sagot, P., David, A. L., Yvinec, M., et al. (2009) · Fetal Diagnosis and Therapy · doi:10.1159/000263621 · Cited by 28 · see citing works
Diagnosis and management of maternal and fetal thyroid disorders
Mestman, J. H. (1999) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-199904000-00009 · Cited by 28 · see citing works
Measurement of Thyroid-Stimulating Hormone in Human Amniotic Fluid*
KOURIDES, I. A., Heath, C. V., & FELLNER, G. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-3-635 · Cited by 24 · see citing works
Johnson, R. L., Finberg, H., PERELMAN, A. H., et al. (1989) · Fetal Diagnosis and Therapy · doi:10.1159/000263436 · Cited by 21 · see citing works
Medeiros-Neto, G. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.12.4239 · Cited by 14 · see citing works
Fetal Goitrous Hypothyroidism Followed by Neonatal Transient Hyperthyroidism
Matsumoto, T., Miyakoshi, K., Kasai, K., et al. (2003) · Fetal Diagnosis and Therapy · doi:10.1159/000073143 · Cited by 12 · see citing works
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Levothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63 · see citing works
- Authors
- Mirsaeid Ghazi, A.-A., Ordookhani, A., Pourafkari, M., Fallahian, M., Bahar, A., Hedayati, M., Hafizi, A., & Azizi, F.
- Affiliations
- Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
- Shahid Beheshti University (IR)
- Taleghani General Hospital (IR)
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2005-12
- Volume
- 15
- Issue
- 12
- Pages
- 1341-1347
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2024402732
- Cited by
- 22
- References
- 36
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2014: 1 · 2012: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Head and Neck Anomalies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- fetal goiter, congenital hypothyroidism, consanguinity, tracheal compression, neonatal asphyxia, delayed skeletal maturation, prenatal diagnosis
- MeSH terms
- Adult, Bone Development, Female, Fetal Diseases, Goiter, Humans, Hypothyroidism, Infant, Newborn, Male, Pregnancy, Prenatal Diagnosis
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