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Cited by 118Ovarian cancer diagnosis and treatmentTesticular diseases and treatmentsThyroid Cancer Diagnosis and Treatment

Malignant Struma Ovarii: A Population-Level Analysis of a Large Series of 68 Patients

Goffredo, Paolo, Sawka, Anna Mary, Pura, John, Adam, Mohamed Abdelgadir, Roman, Sanziana Alina, Sosa, Julie Ann·2015·Thyroid
DOI 10.1089/thy.2014.0328
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Abstract

BACKGROUND: Malignant struma ovarii (MSO) is a germ cell tumor of the ovary histologically identical to differentiated thyroid cancers. There is a paucity of data on this neoplasm, with fewer than 200 reported cases. The primary objective of this study was to examine the survival rate of women diagnosed with MSO using data from the Surveillance, Epidemiology, and End RESULTS (SEER) database. Secondary objectives were to describe the demographic, clinical, pathologic, and treatment characteristics of this population. METHODS: A retrospective analysis was performed of prospectively collected cancer registry data. A total of 68 patients were identified in the SEER database, 1973-2011. The chi-square test, Student's t-test, and Kaplan-Meier curves were employed for data analyses. RESULTS: All 68 patients were females with a mean age at diagnosis of 43.0 years. Nearly 33% underwent unilateral oophorectomy, 28.6% bilateral oophorectomy, and 28.6% oophorectomy and omentectomy, and 4.8% were treated with debulking surgery. Pelvic radiation was administered to 12.3% of patients. The mean tumor size was 52.8 mm; 80% of malignant struma ovarii were SEER staged as local. Overall survival rates at 5, 10, and 20 years were 96.7%, 94.3%, and 84.9% respectively. Among the patients, there were six deaths recorded; only one was attributed to MSO. Six individuals (8.8%) had a concomitant or subsequent diagnosis of thyroid cancer. Four patients underwent total thyroidectomy, three patients had radioactive iodine, and one patient underwent external beam radiation. Two thirds of thyroid cancers extended outside the thyroid gland. All six patients with thyroid cancer were alive at the end of follow-up. CONCLUSIONS: It was observed that patients with malignant struma ovarii had an excellent disease-specific survival rate, regardless of the management strategy employed. However, MSO patients had a high risk for developing aggressive thyroid cancers. Therefore, MSO patients may benefit from routine thyroid imaging once the diagnosis of MSO is established.

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Authors
Goffredo, P., Sawka, A. M., Pura, J., Adam, M. A., Roman, S. A., & Sosa, J. A.
Affiliations
  • Duke University (US)
  • University Health Network (CA)
Corresponding author
Sosa, Julie Ann
ORCID
Venue
Thyroid
Publisher
SAGE Publications
Published
2015-02
Volume
25
Issue
2
Pages
211-215
ISSN
  • 1050-7256 (ISSN-L)
  • 1557-9077
DOI
10.1089/thy.2014.0328
OpenAlex
W1957417179
Cited by
118
References
19
Citations by year
2026: 4 · 2025: 10 · 2024: 15 · 2023: 13 · 2022: 11 · 2021: 17 · 2020: 7 · 2019: 9 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 3
FWCI
8.07
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Thyroid (publishedVersion)
  • PubMed (publishedVersion)
Funders
Cancer Research UK
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
  • Health Sciences › Medicine › Surgery › Testicular diseases and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
malignant struma ovarii, ovarian germ cell tumor, differentiated thyroid cancer, survival, oophorectomy, pelvic radiation, SEER database
MeSH terms
Adolescent, Adult, Aged, Female, Humans, Middle Aged, Ovarian Neoplasms, Retrospective Studies, Struma Ovarii, Survival Rate, SEER Program, Young Adult

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